Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status
IntroductionDescemet membrane endothelial keratoplasty (DMEK) is the main treatment for Fuchs' dystrophy (FECD). The outcomes are excellent, but the final visual recovery may vary from patient to patient with sometimes no obvious reason of such a spread.MethodsWe conducted a clinical prospectiv...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1120283/full |
| _version_ | 1811157809630281728 |
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| author | Charlotte Maffre Charlotte Maffre Pierre Fournié Eve Durbant Carl Arndt Carl Arndt Zoubir Djerada Zoubir Djerada Alexandre Denoyer Alexandre Denoyer Alexandre Denoyer |
| author_facet | Charlotte Maffre Charlotte Maffre Pierre Fournié Eve Durbant Carl Arndt Carl Arndt Zoubir Djerada Zoubir Djerada Alexandre Denoyer Alexandre Denoyer Alexandre Denoyer |
| author_sort | Charlotte Maffre |
| collection | DOAJ |
| description | IntroductionDescemet membrane endothelial keratoplasty (DMEK) is the main treatment for Fuchs' dystrophy (FECD). The outcomes are excellent, but the final visual recovery may vary from patient to patient with sometimes no obvious reason of such a spread.MethodsWe conducted a clinical prospective multicentric study to identify the predictive factors for the visual result 1 year after surgery. Eighty three patients (83 eyes) were included.ResultsPostoperative BCVA after 1 year was 0.20 ± 0.18 logMAR. Logistic regression revealed that good visual recovery correlated negatively with preoperative central macular thickness (p < 0.001) and the need for rebubbling (p = 0.05), and positively with preoperative visual acuity (p = 0.009). Multivariate formula to predict the 1-year BCVA has been suggested.DiscussionPreoperative retinal status seems to be the main predictive factor for long-term visual result after DMEK. Our predictive multivariate model could assist in better informing the patient about the prognosis of the surgery, and in adjusting the therapeutic strategy also, further highlighting the essential collaboration between both cornea and retina subspecialists. |
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| format | Article |
| id | doaj.art-54b0968ad17a4d64baf3a95fe1aafc58 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-10T05:12:35Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-54b0968ad17a4d64baf3a95fe1aafc582023-03-09T06:11:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-03-011010.3389/fmed.2023.11202831120283Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal statusCharlotte Maffre0Charlotte Maffre1Pierre Fournié2Eve Durbant3Carl Arndt4Carl Arndt5Zoubir Djerada6Zoubir Djerada7Alexandre Denoyer8Alexandre Denoyer9Alexandre Denoyer10University of Reims Champagne-Ardenne, Reims, FranceUniversity Hospital Robert Debré, Reims, FranceUniversity of Toulouse III Paul Sabatier, Toulouse, FranceUniversity Hospital Robert Debré, Reims, FranceUniversity of Reims Champagne-Ardenne, Reims, FranceUniversity Hospital Robert Debré, Reims, FranceUniversity of Reims Champagne-Ardenne, Reims, FranceUniversity Hospital Robert Debré, Reims, FranceUniversity of Reims Champagne-Ardenne, Reims, FranceUniversity Hospital Robert Debré, Reims, FranceCARDIOVIR Research Team, EA-4684, University of Reims Champagne-Ardenne, Reims, FranceIntroductionDescemet membrane endothelial keratoplasty (DMEK) is the main treatment for Fuchs' dystrophy (FECD). The outcomes are excellent, but the final visual recovery may vary from patient to patient with sometimes no obvious reason of such a spread.MethodsWe conducted a clinical prospective multicentric study to identify the predictive factors for the visual result 1 year after surgery. Eighty three patients (83 eyes) were included.ResultsPostoperative BCVA after 1 year was 0.20 ± 0.18 logMAR. Logistic regression revealed that good visual recovery correlated negatively with preoperative central macular thickness (p < 0.001) and the need for rebubbling (p = 0.05), and positively with preoperative visual acuity (p = 0.009). Multivariate formula to predict the 1-year BCVA has been suggested.DiscussionPreoperative retinal status seems to be the main predictive factor for long-term visual result after DMEK. Our predictive multivariate model could assist in better informing the patient about the prognosis of the surgery, and in adjusting the therapeutic strategy also, further highlighting the essential collaboration between both cornea and retina subspecialists.https://www.frontiersin.org/articles/10.3389/fmed.2023.1120283/fullcorneaDescemet membrane endothelial keratoplastyFuchscornea guttatapredictive model |
| spellingShingle | Charlotte Maffre Charlotte Maffre Pierre Fournié Eve Durbant Carl Arndt Carl Arndt Zoubir Djerada Zoubir Djerada Alexandre Denoyer Alexandre Denoyer Alexandre Denoyer Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status Frontiers in Medicine cornea Descemet membrane endothelial keratoplasty Fuchs cornea guttata predictive model |
| title | Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status |
| title_full | Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status |
| title_fullStr | Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status |
| title_full_unstemmed | Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status |
| title_short | Identifying predictive factors for long-term visual recovery after corneal endothelial keratoplasty in Fuchs' dystrophy: Potential interaction between the corneal dysfunction and retinal status |
| title_sort | identifying predictive factors for long term visual recovery after corneal endothelial keratoplasty in fuchs dystrophy potential interaction between the corneal dysfunction and retinal status |
| topic | cornea Descemet membrane endothelial keratoplasty Fuchs cornea guttata predictive model |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1120283/full |
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