Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration

Licorice extract inhibits growth of non-small cell lung cancer by down-regulating CDK4-Cyclin D1 complex and increasing CD8+ T cell infiltration

Abstract Background Targeting tumor microenvironment (TME) may provide therapeutic activity and selectivity in treating cancers. Therefore, an improved understanding of the mechanism by which drug targeting TME would enable more informed and effective treatment measures. Glycyrrhiza uralensis Fisch...

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Bibliographic Details
Main Authors: Jinglin Zhu, Ruifei Huang, Ruijie Yang, Yue Xiao, Jiangna Yan, Chunli Zheng, Wei Xiao, Chao Huang, Yonghua Wang
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Cancer Cell International
Subjects:
Tumor microenvironment
NSCLC
Licorice
Systems pharmacology strategy
Online Access:https://doi.org/10.1186/s12935-021-02223-0

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