Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits
ABSTRACT Neuropsychiatric symptoms (NPS) in dementia are prevalent, under-recognized and little studied regarding their pathophysiological aspects. The pathophysiological mechanism, as well as the possible role of vascular lesions in the genesis of these symptoms, are still matters of debate. Objec...
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
2019-09-01
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300293&tlng=en |
| _version_ | 1823965287965261824 |
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| author | Chan Tiel Felipe Kenji Sudo Ana Beatriz Calmon |
| author_facet | Chan Tiel Felipe Kenji Sudo Ana Beatriz Calmon |
| author_sort | Chan Tiel |
| collection | DOAJ |
| description | ABSTRACT Neuropsychiatric symptoms (NPS) in dementia are prevalent, under-recognized and little studied regarding their pathophysiological aspects. The pathophysiological mechanism, as well as the possible role of vascular lesions in the genesis of these symptoms, are still matters of debate. Objective: to describe and compare the prevalence and severity of NPS in subjects with Alzheimer's disease (AD) and vascular dementia (VaD). Methods: a cross-sectional study involving 82 outpatients, divided into two groups (AD × VaD), was conducted. Patients were submitted to the Cambridge Cognitive Test (CAMCOG), the Clock Drawing Test (CLOX 1 and 2), the Neuropsychiatric Inventory (NPI) and the Clinical Dementia Rating (CDR) scale. Neuroimaging was scored using the de Leon and Fazekas scales. Results: 90.8% of the patients had at least one neuropsychiatric symptom. There were statistical differences on the CLOX test and in the apathy symptoms between AD and VaD groups. Apathy and disinhibition proved more prevalent in patients with higher vascular load. Conclusion: apathy and impaired executive function may reflect vascular damage in subcortical circuits in dementia patients. |
| first_indexed | 2024-12-17T17:55:13Z |
| format | Article |
| id | doaj.art-54b7d4aa957f4a789df62965d21bdf36 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-17T17:55:13Z |
| publishDate | 2019-09-01 |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-54b7d4aa957f4a789df62965d21bdf362022-12-21T21:38:36ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57642019-09-0113329329810.1590/1980-57642018dn13-030005Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuitsChan Tielhttps://orcid.org/0000-0001-7999-8675Felipe Kenji SudoAna Beatriz CalmonABSTRACT Neuropsychiatric symptoms (NPS) in dementia are prevalent, under-recognized and little studied regarding their pathophysiological aspects. The pathophysiological mechanism, as well as the possible role of vascular lesions in the genesis of these symptoms, are still matters of debate. Objective: to describe and compare the prevalence and severity of NPS in subjects with Alzheimer's disease (AD) and vascular dementia (VaD). Methods: a cross-sectional study involving 82 outpatients, divided into two groups (AD × VaD), was conducted. Patients were submitted to the Cambridge Cognitive Test (CAMCOG), the Clock Drawing Test (CLOX 1 and 2), the Neuropsychiatric Inventory (NPI) and the Clinical Dementia Rating (CDR) scale. Neuroimaging was scored using the de Leon and Fazekas scales. Results: 90.8% of the patients had at least one neuropsychiatric symptom. There were statistical differences on the CLOX test and in the apathy symptoms between AD and VaD groups. Apathy and disinhibition proved more prevalent in patients with higher vascular load. Conclusion: apathy and impaired executive function may reflect vascular damage in subcortical circuits in dementia patients.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300293&tlng=envascular dementiaAlzheimerneuropsychiatric symptomsapathy |
| spellingShingle | Chan Tiel Felipe Kenji Sudo Ana Beatriz Calmon Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits Dementia & Neuropsychologia vascular dementia Alzheimer neuropsychiatric symptoms apathy |
| title | Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits |
| title_full | Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits |
| title_fullStr | Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits |
| title_full_unstemmed | Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits |
| title_short | Neuropsychiatric symptoms and executive function impairments in Alzheimer’s disease and vascular dementia: The role of subcortical circuits |
| title_sort | neuropsychiatric symptoms and executive function impairments in alzheimer s disease and vascular dementia the role of subcortical circuits |
| topic | vascular dementia Alzheimer neuropsychiatric symptoms apathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642019000300293&tlng=en |
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