The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study
Background: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases. Previous studies have reported an association between stress and salivary alpha-amylase. The aim of this study was to investigate the concentration of salivary alpha-amylase in patients with RA (by elimina...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Dental Research Journal |
| Subjects: | |
| Online Access: | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=43;epage=43;aulast=Pakravan |
| _version_ | 1797824435295617024 |
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| author | Fahimeh Pakravan Mehdi Nasr Isfahani Mateen Ghorbani Naghmeh Salesi Mansour Salesi |
| author_facet | Fahimeh Pakravan Mehdi Nasr Isfahani Mateen Ghorbani Naghmeh Salesi Mansour Salesi |
| author_sort | Fahimeh Pakravan |
| collection | DOAJ |
| description | Background: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases. Previous studies have reported an association between stress and salivary alpha-amylase. The aim of this study was to investigate the concentration of salivary alpha-amylase in patients with RA (by elimination of stress factor).
Materials and Methods: In this case–control study, we enrolled 50 patients with RA and 48 healthy patients as the control group. The perceived stress scale questionnaire was used to evaluate scores of stress in both case and control groups, and then the participants with high scores of stress were excluded from the study. Moreover, the alpha-amylase activity kit was used for the assessment of the levels of salivary alpha-amylase. In all analyses, the significance level was considered to be < 0.05. Finally, the obtained data were analyzed by SPSS22.
Results: Our results indicated a high score of stress in the case group (19.42 ± 5.83 units) compared with the control group (18.02 ± 6.07 units) which was not statistically significant (P < 0.248). Moreover, we demonstrated a high salivary alpha-amylase concentration in the case group (340.65 ± 38.04 units) compared to the control group (302.62 ± 58.72 units), which was statistically significant (P < 0.001). The sensitivity and specificity of this method, at >312 alpha-amylase concentrations, were 80% and 46%, respectively.
Conclusion: In general, we indicated that the alpha-amylase concentration in patients with RA is higher than the healthy controls, and can be used as a codiagnostic factor. |
| first_indexed | 2024-03-13T10:38:56Z |
| format | Article |
| id | doaj.art-54b8711e65ac4dd88c629483c44e84ae |
| institution | Directory Open Access Journal |
| issn | 1735-3327 2008-0255 |
| language | English |
| last_indexed | 2024-03-13T10:38:56Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dental Research Journal |
| spelling | doaj.art-54b8711e65ac4dd88c629483c44e84ae2023-05-18T05:13:30ZengWolters Kluwer Medknow PublicationsDental Research Journal1735-33272008-02552023-01-01201434310.4103/1735-3327.372660The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control studyFahimeh PakravanMehdi Nasr IsfahaniMateen GhorbaniNaghmeh SalesiMansour SalesiBackground: Rheumatoid arthritis (RA) is one of the most common chronic inflammatory diseases. Previous studies have reported an association between stress and salivary alpha-amylase. The aim of this study was to investigate the concentration of salivary alpha-amylase in patients with RA (by elimination of stress factor). Materials and Methods: In this case–control study, we enrolled 50 patients with RA and 48 healthy patients as the control group. The perceived stress scale questionnaire was used to evaluate scores of stress in both case and control groups, and then the participants with high scores of stress were excluded from the study. Moreover, the alpha-amylase activity kit was used for the assessment of the levels of salivary alpha-amylase. In all analyses, the significance level was considered to be < 0.05. Finally, the obtained data were analyzed by SPSS22. Results: Our results indicated a high score of stress in the case group (19.42 ± 5.83 units) compared with the control group (18.02 ± 6.07 units) which was not statistically significant (P < 0.248). Moreover, we demonstrated a high salivary alpha-amylase concentration in the case group (340.65 ± 38.04 units) compared to the control group (302.62 ± 58.72 units), which was statistically significant (P < 0.001). The sensitivity and specificity of this method, at >312 alpha-amylase concentrations, were 80% and 46%, respectively. Conclusion: In general, we indicated that the alpha-amylase concentration in patients with RA is higher than the healthy controls, and can be used as a codiagnostic factor.http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=43;epage=43;aulast=Pakravanrheumatoid arthritissalivary alpha-amylasesstress disorder |
| spellingShingle | Fahimeh Pakravan Mehdi Nasr Isfahani Mateen Ghorbani Naghmeh Salesi Mansour Salesi The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study Dental Research Journal rheumatoid arthritis salivary alpha-amylases stress disorder |
| title | The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study |
| title_full | The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study |
| title_fullStr | The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study |
| title_full_unstemmed | The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study |
| title_short | The salivary alpha-amylase concentration in patients with rheumatoid arthritis: A case–control study |
| title_sort | salivary alpha amylase concentration in patients with rheumatoid arthritis a case control study |
| topic | rheumatoid arthritis salivary alpha-amylases stress disorder |
| url | http://www.drjjournal.net/article.asp?issn=1735-3327;year=2023;volume=20;issue=1;spage=43;epage=43;aulast=Pakravan |
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