Cytochrome <i>c</i> Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

Cytochrome <i>c</i> Oxidase Subunit 4 Isoform Exchange Results in Modulation of Oxygen Affinity

Cytochrome <i>c</i> oxidase (COX) is regulated through tissue-, development- or environment-controlled expression of subunit isoforms. The COX4 subunit is thought to optimize respiratory chain function according to oxygen-controlled expression of its isoforms COX4i1 and COX4i2. However,...

Full description

Bibliographic Details
Main Authors:	David Pajuelo Reguera, Kristýna Čunátová, Marek Vrbacký, Alena Pecinová, Josef Houštěk, Tomáš Mráček, Petr Pecina
Format:	Article
Language:	English
Published:	MDPI AG 2020-02-01
Series:	Cells
Subjects:	mitochondria oxphos respiratory chain cytochrome <i>c</i> oxidase cox cox4 isoforms cox4i2 oxygen affinity p<sub>50</sub> oxygen sensing
Online Access:	https://www.mdpi.com/2073-4409/9/2/443

Similar Items

Loss of COX4I1 Leads to Combined Respiratory Chain Deficiency and Impaired Mitochondrial Protein Synthesis
by: Kristýna Čunátová, et al.
Published: (2021-02-01)

Cox1 mutation abrogates need for Cox23 in cytochrome c oxidase biogenesis
by: Richard Dela Cruz, et al.
Published: (2016-06-01)

Effect of Expression of Nuclear-Encoded Cytochrome C Oxidase Subunit 4 Isoforms on Metabolic Profiles of Glioma Cells
by: Claudia R. Oliva, et al.
Published: (2022-08-01)

The Role of COA6 in the Mitochondrial Copper Delivery Pathway to Cytochrome <i>c</i> Oxidase
by: Abhinav B. Swaminathan, et al.
Published: (2022-01-01)

Upregulation of COX4-2 via HIF-1α in Mitochondrial COX4-1 Deficiency
by: Liza Douiev, et al.
Published: (2021-02-01)

Myiasis caused by Dermatobia hominis in Mexico: morphological and molecular identification using the cytochrome oxidase I gene
by: Fernando Martínez-Hernández, et al.

The ratio of cytochrome c oxidase subunit 4 isoform 4I1 and 4I2 mRNA is changed in permanent atrial fibrillation
by: Sebastian Vogt, et al.
Published: (2024-06-01)

Myocardial insufficiency is related to reduced subunit 4 content of cytochrome c oxidase
by: Sebastian Vogt, et al.
Published: (2018-09-01)

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia
by: Gregory A. Reed, et al.
Published: (2016-11-01)

Fibroblasts mediate the angiogenesis of pheochromocytoma by increasing COX4I2 expression
by: Yongxin Mao, et al.
Published: (2022-09-01)

A small amount of cyclooxygenase 2 (COX2) is constitutively expressed in platelets
by: Qianghua Hu, et al.
Published: (2017-01-01)

Molecular Diversity of the Genus <i>Plagiorchis</i> Lühe, 1899 in Snail Hosts of Central Europe with Evidence of New Lineages
by: Petra Kundid, et al.
Published: (2024-03-01)

Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression
by: Yijian Zhang, et al.
Published: (2023-04-01)

Molecular and Morphological Characterization of Two New Species of <i>Globisporangium</i> from Southern China, <i>G. pengfuense</i> and <i>G. tenuihyphum</i>
by: Jia-Jia Chen, et al.
Published: (2022-06-01)

Design, Synthesis, Biological Evaluation, and Molecular Docking Study of 4,6-Dimethyl-5-aryl/alkyl-2-[2-hydroxy-3-(4-substituted-1-piperazinyl)propyl]pyrrolo[3,4-<i>c</i>]pyrrole-1,3(2<i>H</i>,5<i>H</i>)-diones as Anti-Inflammatory Agents with Dual Inhibition of COX and LOX
by: Aleksandra Redzicka, et al.
Published: (2023-05-01)

Evaluation of the Inhibitory Effects of Pyridylpyrazole Derivatives on LPS-Induced PGE<sub>2</sub> Productions and Nitric Oxide in Murine RAW 264.7 Macrophages
by: Mahmoud M. Gamal El-Din, et al.
Published: (2021-10-01)

Exploring <i>Echinops polyceras</i> Boiss. from Jordan: Essential Oil Composition, COX, Protein Denaturation Inhibitory Power and Antimicrobial Activity of the Alcoholic Extract
by: Hazem S. Hasan, et al.
Published: (2023-05-01)

Identification of <i>Sarcocystis</i> spp. in One-humped Camels (<i>Camelus dromedarius</i>) from Riyadh and Dammam, Saudi Arabia, via Histological and Phylogenetic Approaches
by: Dina M. Metwally, et al.
Published: (2020-06-01)

In silico structural characterization of Cytochrome c oxidase Subunit 1: A transmembrane protein from Aedes aegypti
by: Jhansi Venkata Nagamani Josyula, et al.
Published: (2021-01-01)

Molecular detection and phylogenetic analysis of Bovicola caprae in the west and northwest of Iran based on cytochrome oxidase 1 marker
by: Khadijeh Seydigazafi, et al.
Published: (2022-09-01)

Potential Anti-Diabetic Activity of <i>Pueraria lobata</i> Flower (Flos Puerariae) Extracts
by: Pattawika Lertpatipanpong, et al.
Published: (2020-08-01)

Anti-Inflammatory Activity of Essential Oil from <i>Zingiber ottensii</i> Valeton in Animal Models
by: Wisit Thitinarongwate, et al.
Published: (2022-07-01)

Morphological and Molecular Characterization Using Genitalia and <i>CoxI</i> Barcode Sequence Analysis of Afrotropical Mosquitoes with Arbovirus Vector Potential
by: Eddyson Montalvo-Sabino, et al.
Published: (2022-11-01)

Morphological and Molecular Characterization of <i>Trichuris</i> sp. (Nematoda: Trichuridae) in Crested Porcupines (<i>Hystrix cristata</i>; Rodentia: Hystricidae) from Italy
by: Serena Cavallero, et al.
Published: (2021-11-01)

Extracellular Vesicles Secreted by <i>Acanthamoeba culbertsoni</i> Have COX and Proteolytic Activity and Induce Hemolysis
by: Francisco Sierra-López, et al.
Published: (2023-11-01)

Briarenols Q–T: Briaranes from A Cultured Octocoral <i>Briareum stechei</i> (Kükenthal, 1908)
by: Yi-Lin Zhang, et al.
Published: (2020-07-01)

The Role of Prostaglandins in Different Types of Cancer
by: Álvaro Jara-Gutiérrez, et al.
Published: (2021-06-01)

Distribution and Polymorphisms of Group I Introns in Mitochondrial Genes from <i>Cryptococcus neoformans</i> and <i>Cryptococcus gattii</i>
by: Ronald Muryellison Oliveira da Silva Gomes, et al.
Published: (2023-05-01)

Microbial Transformation of the Sesquiterpene Lactone, Vulgarin, by <i>Aspergillus niger</i>
by: Reem A. ElGamal, et al.
Published: (2023-04-01)

Neuroprotective Effects of Chemical Constituents of Leaves of <i>Euonymus hamiltonianus</i> Wall.
by: Huynh Nguyen Khanh Tran, et al.
Published: (2024-04-01)

Molecular characterization of human isolates of Strongyloides stercoralis and Rhabditis spp. based on mitochondrial cytochrome c oxidase subunit 1 (cox1)
by: Mandana Fadaei Tehrani, et al.
Published: (2019-09-01)

Accelerated Evolution of Cytochrome <i>c</i> in Higher Primates, and Regulation of the Reaction between Cytochrome <i>c</i> and Cytochrome Oxidase by Phosphorylation
by: Sue Ellen Brand, et al.
Published: (2022-12-01)

Briarenols W–Z: Chlorine-Containing Polyoxygenated Briaranes from Octocoral <i>Briareum stechei</i> (Kükenthal, 1908)
by: You-Ying Chen, et al.
Published: (2021-01-01)

Canine Gallbladder Erosion/Ulcer and Hemocholecyst: Clinicopathological Characteristics of 14 Cases
by: Ikki Mitsui, et al.
Published: (2023-10-01)

Composition and Acute Inflammatory Response from <i>Tetraponera rufonigra</i> Venom on RAW 264.7 Macrophage Cells
by: Suwatjanee Naephrai, et al.
Published: (2021-04-01)

Neuron–Microglia Contacts Govern the PGE<sub>2</sub> Tolerance through TLR4-Mediated de Novo Protein Synthesis
by: Hsing-Chun Kuo, et al.
Published: (2022-02-01)

Isolation, In Vitro and In Silico Anti-Alzheimer and Anti-Inflammatory Studies on Phytosteroids from Aerial Parts of <i>Fragaria × ananassa</i> Duch
by: Mater H. Mahnashi, et al.
Published: (2022-10-01)

Detection of Three <i>Sarcocystis</i> Species (Apicomplexa) in Blood Samples of the Bank Vole and Yellow-Necked Mouse from Lithuania
by: Petras Prakas, et al.
Published: (2024-03-01)

Haplotype Diversity in mtDNA of Honeybee in the Czech Republic Confirms Complete Replacement of Autochthonous Population with the C Lineage
by: Aleš Knoll, et al.
Published: (2024-07-01)

Copper-Induced Enhancement of Glioblastoma Tumorigenicity via Cytochrome C Oxidase
by: Claudia R. Oliva, et al.
Published: (2025-01-01)