Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers

Breast cancer is the second most frequent cause of mortality for women and one of the most prevalent malignant tumors that jeopardize women's health and unfortunately its prevalence is rising globally. Breast cancer has been diagnosed and treated to date by employing frequently used techniques...

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Main Authors: Armin Jarahi Khameneh, Sarvin Rahimi, Mohammed H. Abbas, Shayan Rahimi, Saeideh Mehmandoust, Abbas Rastgoo, Ashkan Heydarian, Vahid Eskandari
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Chemical Physics Impact
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2667022423002645
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author Armin Jarahi Khameneh
Sarvin Rahimi
Mohammed H. Abbas
Shayan Rahimi
Saeideh Mehmandoust
Abbas Rastgoo
Ashkan Heydarian
Vahid Eskandari
author_facet Armin Jarahi Khameneh
Sarvin Rahimi
Mohammed H. Abbas
Shayan Rahimi
Saeideh Mehmandoust
Abbas Rastgoo
Ashkan Heydarian
Vahid Eskandari
author_sort Armin Jarahi Khameneh
collection DOAJ
description Breast cancer is the second most frequent cause of mortality for women and one of the most prevalent malignant tumors that jeopardize women's health and unfortunately its prevalence is rising globally. Breast cancer has been diagnosed and treated to date by employing frequently used techniques such as mammography, magnetic resonance imaging (MRI), molecular breast imaging (MBI), biopsy, enzyme-linked immunosorbent assay (ELISA), fluorescence hybridization, polymerase chain reaction (PCR), immunohistochemistry, and flow cytometry. Nevertheless, some of these techniques are relatively complex, time-consuming, and not cost-effective, and even the low sensitivity and specificity of some of these platforms have caused these approaches not to receive much attention from researchers and clinical experts. For early identification and monitoring of cancer recurrence, the detection of low quantities of cancer biomarkers with high sensitivity and reproducibility is essential. While the detection of breast cancer by traditional methods is expensive, invasive, time-consuming, and sometimes has incorrect results, the development of an affordable technique that can diagnose breast cancer qualitatively or quantitatively in its early stages is one of the basic needs in this field. Due to their selectivity and high sensitivity, easy and quick detection, and lack of need for costly and specialized instruments, electrochemical biosensors have drawn particular interest. Therefore, the electrochemical method is considered an alternative to detect breast cancer biomarkers. In this review, some designed or developed electrochemical sensors and the methods and strategies for making these sensors for early detection of breast cancer are reviewed. The limitations and challenges of these investigations and obstacles to the commercialization of these systems are examined.
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spelling doaj.art-54b8dcc5d1c943ca9b89e1633036f63d2023-12-23T05:23:02ZengElsevierChemical Physics Impact2667-02242024-06-018100425Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkersArmin Jarahi Khameneh0Sarvin Rahimi1Mohammed H. Abbas2Shayan Rahimi3Saeideh Mehmandoust4Abbas Rastgoo5Ashkan Heydarian6Vahid Eskandari7School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, Iran; Corresponding authors.School of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, IranDepartment of Physics, College of Education for Pure Sciences, University of Babylon, Babylon, IraqSchool of Mechanical Engineering, College of Engineering, Tarbiat Modares University, Tehran, IranDivision of Nanobiotechnology, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran, IranSchool of Mechanical Engineering, College of Engineering, University of Tehran, Tehran, IranDepartment of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, IranNanoscience and Nanotechnology Research Center, University of Kashan, Kashan, Iran; Corresponding authors.Breast cancer is the second most frequent cause of mortality for women and one of the most prevalent malignant tumors that jeopardize women's health and unfortunately its prevalence is rising globally. Breast cancer has been diagnosed and treated to date by employing frequently used techniques such as mammography, magnetic resonance imaging (MRI), molecular breast imaging (MBI), biopsy, enzyme-linked immunosorbent assay (ELISA), fluorescence hybridization, polymerase chain reaction (PCR), immunohistochemistry, and flow cytometry. Nevertheless, some of these techniques are relatively complex, time-consuming, and not cost-effective, and even the low sensitivity and specificity of some of these platforms have caused these approaches not to receive much attention from researchers and clinical experts. For early identification and monitoring of cancer recurrence, the detection of low quantities of cancer biomarkers with high sensitivity and reproducibility is essential. While the detection of breast cancer by traditional methods is expensive, invasive, time-consuming, and sometimes has incorrect results, the development of an affordable technique that can diagnose breast cancer qualitatively or quantitatively in its early stages is one of the basic needs in this field. Due to their selectivity and high sensitivity, easy and quick detection, and lack of need for costly and specialized instruments, electrochemical biosensors have drawn particular interest. Therefore, the electrochemical method is considered an alternative to detect breast cancer biomarkers. In this review, some designed or developed electrochemical sensors and the methods and strategies for making these sensors for early detection of breast cancer are reviewed. The limitations and challenges of these investigations and obstacles to the commercialization of these systems are examined.http://www.sciencedirect.com/science/article/pii/S2667022423002645Electrochemical biosensorsBreast cancerBreast cancer biomarkersEarly detection
spellingShingle Armin Jarahi Khameneh
Sarvin Rahimi
Mohammed H. Abbas
Shayan Rahimi
Saeideh Mehmandoust
Abbas Rastgoo
Ashkan Heydarian
Vahid Eskandari
Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
Chemical Physics Impact
Electrochemical biosensors
Breast cancer
Breast cancer biomarkers
Early detection
title Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
title_full Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
title_fullStr Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
title_full_unstemmed Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
title_short Trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
title_sort trends in electrochemical biosensors for the early diagnosis of breast cancer through the detection of relevant biomarkers
topic Electrochemical biosensors
Breast cancer
Breast cancer biomarkers
Early detection
url http://www.sciencedirect.com/science/article/pii/S2667022423002645
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