BDNF-dependent consolidation of fear memories in the perirhinal cortex
In the recent years the perirhinal cortex (PRh) has been identified as a crucial brain area in fear learning. Since the neurotrophin BDNF (brain-derived neurotrophic factor) is an important mediator of synaptic plasticity and also crucially involved in memory consolidation of several learning paradi...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00205/full |
| _version_ | 1828473005901086720 |
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| author | Brigitte eSchulz-Klaus Volkmar eLessmann Thomas eEndres |
| author_facet | Brigitte eSchulz-Klaus Volkmar eLessmann Thomas eEndres |
| author_sort | Brigitte eSchulz-Klaus |
| collection | DOAJ |
| description | In the recent years the perirhinal cortex (PRh) has been identified as a crucial brain area in fear learning. Since the neurotrophin BDNF (brain-derived neurotrophic factor) is an important mediator of synaptic plasticity and also crucially involved in memory consolidation of several learning paradigms, we analyzed now whether fear conditioning influences the expression of BDNF protein in the PRh. Here we observed a specific increase of BDNF protein 120 minutes after fear conditioning training. In order to test whether this increase of BDNF protein level is also required for the consolidation of the fear memory, we locally applied the Trk receptor inhibitor k252a into the PRh during this time window in a second series of experiments. By interfering with BDNF-TrkB-signaling during this critical time window, the formation of a long-term fear memory was completely blocked, indicated by a complete lack of fear potentiated startle one day later. In conclusion the present study further emphasizes the important role of the PRh in cued fear learning and identified BDNF as an important mediator for fear memory consolidation in the PRh. |
| first_indexed | 2024-12-11T05:36:59Z |
| format | Article |
| id | doaj.art-54b9e9ebda924d85ae732e9a4f6cd9ba |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T05:36:59Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-54b9e9ebda924d85ae732e9a4f6cd9ba2022-12-22T01:19:14ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532013-12-01710.3389/fnbeh.2013.0020567700BDNF-dependent consolidation of fear memories in the perirhinal cortexBrigitte eSchulz-Klaus0Volkmar eLessmann1Thomas eEndres2University of TübingenOtto-von-Guericke UniversityOtto-von-Guericke UniversityIn the recent years the perirhinal cortex (PRh) has been identified as a crucial brain area in fear learning. Since the neurotrophin BDNF (brain-derived neurotrophic factor) is an important mediator of synaptic plasticity and also crucially involved in memory consolidation of several learning paradigms, we analyzed now whether fear conditioning influences the expression of BDNF protein in the PRh. Here we observed a specific increase of BDNF protein 120 minutes after fear conditioning training. In order to test whether this increase of BDNF protein level is also required for the consolidation of the fear memory, we locally applied the Trk receptor inhibitor k252a into the PRh during this time window in a second series of experiments. By interfering with BDNF-TrkB-signaling during this critical time window, the formation of a long-term fear memory was completely blocked, indicated by a complete lack of fear potentiated startle one day later. In conclusion the present study further emphasizes the important role of the PRh in cued fear learning and identified BDNF as an important mediator for fear memory consolidation in the PRh.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00205/fullBrain-Derived Neurotrophic FactorBDNFconsolidationperirhinal cortexFear potentiated startlefear learning |
| spellingShingle | Brigitte eSchulz-Klaus Volkmar eLessmann Thomas eEndres BDNF-dependent consolidation of fear memories in the perirhinal cortex Frontiers in Behavioral Neuroscience Brain-Derived Neurotrophic Factor BDNF consolidation perirhinal cortex Fear potentiated startle fear learning |
| title | BDNF-dependent consolidation of fear memories in the perirhinal cortex |
| title_full | BDNF-dependent consolidation of fear memories in the perirhinal cortex |
| title_fullStr | BDNF-dependent consolidation of fear memories in the perirhinal cortex |
| title_full_unstemmed | BDNF-dependent consolidation of fear memories in the perirhinal cortex |
| title_short | BDNF-dependent consolidation of fear memories in the perirhinal cortex |
| title_sort | bdnf dependent consolidation of fear memories in the perirhinal cortex |
| topic | Brain-Derived Neurotrophic Factor BDNF consolidation perirhinal cortex Fear potentiated startle fear learning |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2013.00205/full |
| work_keys_str_mv | AT brigitteeschulzklaus bdnfdependentconsolidationoffearmemoriesintheperirhinalcortex AT volkmarelessmann bdnfdependentconsolidationoffearmemoriesintheperirhinalcortex AT thomaseendres bdnfdependentconsolidationoffearmemoriesintheperirhinalcortex |