Comparison of Umbilical Cord Mesenchymal Stem Cells and Fibroblasts as Donor Nuclei for Handmade Cloning in Sheep Using a Single-Cell Transcriptome

Comparison of Umbilical Cord Mesenchymal Stem Cells and Fibroblasts as Donor Nuclei for Handmade Cloning in Sheep Using a Single-Cell Transcriptome

Oocytes are efficient at reprogramming terminally differentiated cells to a totipotent state. Nuclear transfer techniques can exploit this property to produce cloned animals. However, the overall efficiency is low. The use of umbilical cord mesenchymal stem cells (UC-MSCs) as donor nuclei may increa...

Full description

Bibliographic Details
Main Authors: Weijian Li, Yalan Liu, Guizhen Zhou, Zhuo Li, Zhen Wang, Li Wang, Xiuling Ma, Xuguang Wang
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Animals
Subjects:
single-cell transcriptome
umbilical cord mesenchymal stem cells
sheep
handmade cloning
nuclear transplantation
Online Access:https://www.mdpi.com/2076-2615/14/4/589

Internet

https://www.mdpi.com/2076-2615/14/4/589

Similar Items