Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment
The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with gree...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/6/1222 |
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| author | Katharine Valéria Saraiva Hodel Bruna Aparecida Souza Machado Giulia da Costa Sacramento Carine Assunção de Oliveira Maciel Gessualdo Seixas Oliveira-Junior Breno Noronha Matos Guilherme Martins Gelfuso Silmar Baptista Nunes Josiane Dantas Viana Barbosa Ana Leonor Pardo Campos Godoy |
| author_facet | Katharine Valéria Saraiva Hodel Bruna Aparecida Souza Machado Giulia da Costa Sacramento Carine Assunção de Oliveira Maciel Gessualdo Seixas Oliveira-Junior Breno Noronha Matos Guilherme Martins Gelfuso Silmar Baptista Nunes Josiane Dantas Viana Barbosa Ana Leonor Pardo Campos Godoy |
| author_sort | Katharine Valéria Saraiva Hodel |
| collection | DOAJ |
| description | The use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds <i>p</i>-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T<sub>600</sub> mm<sup>−1</sup>), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m<sup>2</sup> day<sup>−1</sup>), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL<sup>−1</sup>). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties. |
| first_indexed | 2024-03-09T22:45:25Z |
| format | Article |
| id | doaj.art-54bf32877b97417c95d74894501d0f47 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T22:45:25Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-54bf32877b97417c95d74894501d0f472023-11-23T18:30:14ZengMDPI AGPharmaceutics1999-49232022-06-01146122210.3390/pharmaceutics14061222Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion TreatmentKatharine Valéria Saraiva Hodel0Bruna Aparecida Souza Machado1Giulia da Costa Sacramento2Carine Assunção de Oliveira Maciel3Gessualdo Seixas Oliveira-Junior4Breno Noronha Matos5Guilherme Martins Gelfuso6Silmar Baptista Nunes7Josiane Dantas Viana Barbosa8Ana Leonor Pardo Campos Godoy9SENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, BrazilSENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, BrazilSENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, BrazilDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, BrazilDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, BrazilLaboratory of Medicines, Food and Cosmetics (LTMAC), University of Brasília, Brasilia 70910-900, BrazilLaboratory of Medicines, Food and Cosmetics (LTMAC), University of Brasília, Brasilia 70910-900, BrazilSENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, BrazilSENAI Institute for Innovation in Advanced Health Systems (CIMATEC ISI SAS), SENAI/CIMATEC University Center, Salvador 41650-010, BrazilDepartment of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Bahia, Salvador 40170-115, BrazilThe use of innate products for the fast and efficient promotion of healing process has been one of the biomedical sector’s main bets for lesion treatment modernization process. The aim of this study was to develop and characterize bacterial cellulose-based (BC) wound dressings incorporated with green and red propolis extract (2 to 4%) and the active compounds <i>p</i>-coumaric acid and biochanin A (8 to 16 mg). The characterization of the nine developed samples (one control and eight active wound dressings) evidenced that the mechanics, physics, morphological, and barrier properties depended not only on the type of active principle incorporated onto the cellulosic matrix, but also on its concentration. Of note were the results found for transparency (28.59–110.62T<sub>600</sub> mm<sup>−1</sup>), thickness (0.023–0.046 mm), swelling index (48.93–405.55%), water vapor permeability rate (7.86–38.11 g m<sup>2</sup> day<sup>−1</sup>), elongation (99.13–262.39%), and antioxidant capacity (21.23–86.76 μg mL<sup>−1</sup>). The wound dressing based on BC and red propolis was the only one that presented antimicrobial activity. The permeation and retention test revealed that the wound dressing containing propolis extract presented the most corneal stratum when compared with viable skin. Overall, the developed wound dressing showed potential to be used for treatment against different types of dermal lesions, according to its determined proprieties.https://www.mdpi.com/1999-4923/14/6/1222bacterial cellulosewound dressingdermal lesionspropolis<i>p</i>-coumaric acidbiochanin A |
| spellingShingle | Katharine Valéria Saraiva Hodel Bruna Aparecida Souza Machado Giulia da Costa Sacramento Carine Assunção de Oliveira Maciel Gessualdo Seixas Oliveira-Junior Breno Noronha Matos Guilherme Martins Gelfuso Silmar Baptista Nunes Josiane Dantas Viana Barbosa Ana Leonor Pardo Campos Godoy Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment Pharmaceutics bacterial cellulose wound dressing dermal lesions propolis <i>p</i>-coumaric acid biochanin A |
| title | Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment |
| title_full | Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment |
| title_fullStr | Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment |
| title_full_unstemmed | Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment |
| title_short | Active Potential of Bacterial Cellulose-Based Wound Dressing: Analysis of Its Potential for Dermal Lesion Treatment |
| title_sort | active potential of bacterial cellulose based wound dressing analysis of its potential for dermal lesion treatment |
| topic | bacterial cellulose wound dressing dermal lesions propolis <i>p</i>-coumaric acid biochanin A |
| url | https://www.mdpi.com/1999-4923/14/6/1222 |
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