Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls
There is a growing interest in the technological transfer of highly performing electrochemical sensors within portable analytical devices for the in situ monitoring of environmental contaminants, such as perfluorooctanesulfonic acid (PFOS). In the redesign of biomimetic sensors, many parameters shou...
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| Format: | Article |
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MDPI AG
2019-10-01
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| Series: | Sensors |
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| Online Access: | https://www.mdpi.com/1424-8220/19/20/4433 |
| _version_ | 1811301056923041792 |
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| author | Giulia Moro Davide Cristofori Fabio Bottari Elti Cattaruzza Karolien De Wael Ligia Maria Moretto |
| author_facet | Giulia Moro Davide Cristofori Fabio Bottari Elti Cattaruzza Karolien De Wael Ligia Maria Moretto |
| author_sort | Giulia Moro |
| collection | DOAJ |
| description | There is a growing interest in the technological transfer of highly performing electrochemical sensors within portable analytical devices for the in situ monitoring of environmental contaminants, such as perfluorooctanesulfonic acid (PFOS). In the redesign of biomimetic sensors, many parameters should be taken into account from the working conditions to the electrode surface roughness. A complete characterization of the surface modifiers can help to avoid time-consuming optimizations and better interpret the sensor responses. In the present study, a molecularly imprinted polymer electrochemical sensor (MIP) for PFOS optimized on gold disk electrodes was redesigned on commercial gold screen-printed electrodes. However, its performance investigated by differential pulse voltammetry was found to be poor. Before proceeding with further optimization, a morphological study of the bare and modified electrode surfaces was carried out by scanning electron microscopy−energy-dispersive X-ray spectrometry (SEM−EDS), atomic force microscopy (AFM) and profilometry revealing an heterogeneous distribution of the polymer strongly influenced by the electrode roughness. The high content of fluorine of the target-template molecule allowed to map the distribution of the molecularly imprinted polymer before the template removal and to define a characterization protocol. This case study shows the importance of a multi-analytical characterization approach and identify significant parameters to be considered in similar redesigning studies. |
| first_indexed | 2024-04-13T07:02:04Z |
| format | Article |
| id | doaj.art-54c178a02a5b485cb583e0f2f3418b5f |
| institution | Directory Open Access Journal |
| issn | 1424-8220 |
| language | English |
| last_indexed | 2024-04-13T07:02:04Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Sensors |
| spelling | doaj.art-54c178a02a5b485cb583e0f2f3418b5f2022-12-22T02:57:05ZengMDPI AGSensors1424-82202019-10-011920443310.3390/s19204433s19204433Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and PitfallsGiulia Moro0Davide Cristofori1Fabio Bottari2Elti Cattaruzza3Karolien De Wael4Ligia Maria Moretto5Department of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Mestre, ItalyDepartment of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Mestre, ItalyAXES Research Group, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, BelgiumDepartment of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Mestre, ItalyAXES Research Group, Department of Chemistry, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerp, BelgiumDepartment of Molecular Sciences and Nanosystems, Ca’ Foscari University of Venice, Via Torino 155, 30172 Mestre, ItalyThere is a growing interest in the technological transfer of highly performing electrochemical sensors within portable analytical devices for the in situ monitoring of environmental contaminants, such as perfluorooctanesulfonic acid (PFOS). In the redesign of biomimetic sensors, many parameters should be taken into account from the working conditions to the electrode surface roughness. A complete characterization of the surface modifiers can help to avoid time-consuming optimizations and better interpret the sensor responses. In the present study, a molecularly imprinted polymer electrochemical sensor (MIP) for PFOS optimized on gold disk electrodes was redesigned on commercial gold screen-printed electrodes. However, its performance investigated by differential pulse voltammetry was found to be poor. Before proceeding with further optimization, a morphological study of the bare and modified electrode surfaces was carried out by scanning electron microscopy−energy-dispersive X-ray spectrometry (SEM−EDS), atomic force microscopy (AFM) and profilometry revealing an heterogeneous distribution of the polymer strongly influenced by the electrode roughness. The high content of fluorine of the target-template molecule allowed to map the distribution of the molecularly imprinted polymer before the template removal and to define a characterization protocol. This case study shows the importance of a multi-analytical characterization approach and identify significant parameters to be considered in similar redesigning studies.https://www.mdpi.com/1424-8220/19/20/4433pfosmolecularly imprinted polymerbiomimetic sensorgold screen-printed electrodesortho-phenylenediamine |
| spellingShingle | Giulia Moro Davide Cristofori Fabio Bottari Elti Cattaruzza Karolien De Wael Ligia Maria Moretto Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls Sensors pfos molecularly imprinted polymer biomimetic sensor gold screen-printed electrodes ortho-phenylenediamine |
| title | Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls |
| title_full | Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls |
| title_fullStr | Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls |
| title_full_unstemmed | Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls |
| title_short | Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls |
| title_sort | redesigning an electrochemical mip sensor for pfos practicalities and pitfalls |
| topic | pfos molecularly imprinted polymer biomimetic sensor gold screen-printed electrodes ortho-phenylenediamine |
| url | https://www.mdpi.com/1424-8220/19/20/4433 |
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