Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease
Adipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and perivascular fat depots are of great interest to researchers, owing to their potential effects on the myocardium and blo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/2/129 |
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| author | Olga V. Gruzdeva Yulia A. Dyleva Ekaterina V. Belik Maxim Y. Sinitsky Aleksandr N. Stasev Aleksandr N. Kokov Natalia K. Brel Evgenia O. Krivkina Evgenia E. Bychkova Roman S. Tarasov Olga L. Barbarash |
| author_facet | Olga V. Gruzdeva Yulia A. Dyleva Ekaterina V. Belik Maxim Y. Sinitsky Aleksandr N. Stasev Aleksandr N. Kokov Natalia K. Brel Evgenia O. Krivkina Evgenia E. Bychkova Roman S. Tarasov Olga L. Barbarash |
| author_sort | Olga V. Gruzdeva |
| collection | DOAJ |
| description | Adipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and perivascular fat depots are of great interest to researchers, owing to their potential effects on the myocardium and blood vessels. The aim of the study was to assess the expression and secretion of adipocytokine genes in the AT of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. This study included 84 patients with CAD and 50 patients with aortic or mitral valve replacement. Adipocytes were isolated from subcutaneous, epicardial (EAT), and perivascular AT (PVAT), and were cultured for 24 h. EAT exhibited the lowest level of adiponectin gene expression and secretion, regardless of nosology, and high expression levels of the leptin gene and interleukin-6 (IL-6). However, EAT adipocytes in patients with CAD were characterized by more pronounced changes in comparison with the group with heart defects. High leptin and IL-6 levels resulted in increased pro-inflammatory activity, as observed in both EAT and PVAT adipocytes, especially in individuals with CAD. Therefore, our results revealed the pathogenetic significance of alterations in the adipokine and cytokine status of adipocytes of EAT and PVAT in patients with CAD. |
| first_indexed | 2024-03-09T21:38:09Z |
| format | Article |
| id | doaj.art-54c345cc94ce4b1aabd8df059c366021 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T21:38:09Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-54c345cc94ce4b1aabd8df059c3660212023-11-23T20:38:42ZengMDPI AGJournal of Personalized Medicine2075-44262022-01-0112212910.3390/jpm12020129Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery DiseaseOlga V. Gruzdeva0Yulia A. Dyleva1Ekaterina V. Belik2Maxim Y. Sinitsky3Aleksandr N. Stasev4Aleksandr N. Kokov5Natalia K. Brel6Evgenia O. Krivkina7Evgenia E. Bychkova8Roman S. Tarasov9Olga L. Barbarash10Federal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaFederal State Budgetary Scientific Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 650002 Kemerovo, RussiaAdipose tissue (AT) is an endocrine and paracrine organ that synthesizes biologically active adipocytokines, which affect inflammation, fibrosis, and atherogenesis. Epicardial and perivascular fat depots are of great interest to researchers, owing to their potential effects on the myocardium and blood vessels. The aim of the study was to assess the expression and secretion of adipocytokine genes in the AT of patients with coronary artery disease (CAD) and patients with aortic or mitral valve replacement. This study included 84 patients with CAD and 50 patients with aortic or mitral valve replacement. Adipocytes were isolated from subcutaneous, epicardial (EAT), and perivascular AT (PVAT), and were cultured for 24 h. EAT exhibited the lowest level of adiponectin gene expression and secretion, regardless of nosology, and high expression levels of the leptin gene and interleukin-6 (IL-6). However, EAT adipocytes in patients with CAD were characterized by more pronounced changes in comparison with the group with heart defects. High leptin and IL-6 levels resulted in increased pro-inflammatory activity, as observed in both EAT and PVAT adipocytes, especially in individuals with CAD. Therefore, our results revealed the pathogenetic significance of alterations in the adipokine and cytokine status of adipocytes of EAT and PVAT in patients with CAD.https://www.mdpi.com/2075-4426/12/2/129adiponectinleptininterleukin-6epicardial adipose tissueperivascular adipose tissue |
| spellingShingle | Olga V. Gruzdeva Yulia A. Dyleva Ekaterina V. Belik Maxim Y. Sinitsky Aleksandr N. Stasev Aleksandr N. Kokov Natalia K. Brel Evgenia O. Krivkina Evgenia E. Bychkova Roman S. Tarasov Olga L. Barbarash Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease Journal of Personalized Medicine adiponectin leptin interleukin-6 epicardial adipose tissue perivascular adipose tissue |
| title | Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease |
| title_full | Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease |
| title_fullStr | Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease |
| title_full_unstemmed | Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease |
| title_short | Relationship between Epicardial and Coronary Adipose Tissue and the Expression of Adiponectin, Leptin, and Interleukin 6 in Patients with Coronary Artery Disease |
| title_sort | relationship between epicardial and coronary adipose tissue and the expression of adiponectin leptin and interleukin 6 in patients with coronary artery disease |
| topic | adiponectin leptin interleukin-6 epicardial adipose tissue perivascular adipose tissue |
| url | https://www.mdpi.com/2075-4426/12/2/129 |
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