papillary thyroid carcinoma
Introduction: Thyroid hormone replacement in central hypothyroidism (CHT) is more difficult than in primary hypothyroidism (PHT), putting patients at risk for inappropriate substitution. In this study, we compared the dosage of thyroid hormone replacement in patients with CHT with that of patients w...
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| Format: | Article |
| Language: | English |
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Bioscientifica
2023-01-01
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| Series: | European Thyroid Journal |
| Subjects: | |
| Online Access: | https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-21-0128.xml |
| _version_ | 1828064814300135424 |
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| author | Joke Marlier Guy T’Sjoen Jean Kaufman Bruno Lapauw |
| author_facet | Joke Marlier Guy T’Sjoen Jean Kaufman Bruno Lapauw |
| author_sort | Joke Marlier |
| collection | DOAJ |
| description | Introduction: Thyroid hormone replacement in central hypothyroidism (CHT) is more difficult than in primary hypothyroidism (PHT), putting patients at risk for inappropriate substitution. In this study, we compared the dosage of thyroid hormone replacement in patients with CHT with that of patients with PHT. In addition, we explored and compared quality of life (QoL) between both groups, based on two questionnaires, the SF-36 health score and the thyroid-specific ThyPRO score.
Methods: This is a monocentric, cross-sectional study, performed at the Ghent University Hospital (Belgium). We included 82 patients in total, 41 patients with CHT and 41 patients with PHT. At the time of inclusion, all patients had to have a stable dose of levothyroxine over the past 6 months and patients with PHT needed to be euthy roid (defined as having a thyroid-stimulating hormone level within the reference range, 0.2–4.5 mU/L). All data were retrieved from medical files, and questionnaires on QoL wer e self-administered.
Results: The CHT and PHT groups were comparable regarding age and BMI. There was no significant difference between both groups regarding total daily dose of levothyroxine (100 (93.75–125.00) vs 107.14 (75.00–133.93) μg in CHT and PHT, respectively; P = 0.87) or daily dose of levothyroxine per kg body weight (1.34 (1.16–1.55 ) vs 1.55 (1.16–1.82) μg/kg, respectively; P = 0.13). Serum levels of fT4 (P = 0.20) and fT3 (P = 0.10) also did not differ between the two groups and both were in the normal (mid)range for the two groups. Regarding QoL, patients with CHT scored worse in terms of depressive and emotional symptoms, impaired daily and social life.
Conclusion: We could demonstrate a difference in QoL between patients with CHT and PHT. Although patients with CHT had a somewhat lower levothyroxine substitution dose than patients with PHT, this difference was also not significant and probably does not explain the difference in QoL. |
| first_indexed | 2024-04-10T23:04:29Z |
| format | Article |
| id | doaj.art-54c7323b990f400fa06556a1e50942a7 |
| institution | Directory Open Access Journal |
| issn | 2235-0802 |
| language | English |
| last_indexed | 2024-04-10T23:04:29Z |
| publishDate | 2023-01-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | European Thyroid Journal |
| spelling | doaj.art-54c7323b990f400fa06556a1e50942a72023-01-13T12:47:46ZengBioscientificaEuropean Thyroid Journal2235-08022023-01-0111616https://doi.org/10.1530/ETJ-21-0128papillary thyroid carcinomaJoke Marlier0Guy T’Sjoen1Jean Kaufman2Bruno Lapauw3Department of Endocrinology, Ghent University Hospital, Ghent, BelgiumDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine & Pediatrics, Ghent University, Ghent, BelgiumDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine & Pediatrics, Ghent University, Ghent, BelgiumDepartment of Endocrinology, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine & Pediatrics, Ghent University, Ghent, BelgiumIntroduction: Thyroid hormone replacement in central hypothyroidism (CHT) is more difficult than in primary hypothyroidism (PHT), putting patients at risk for inappropriate substitution. In this study, we compared the dosage of thyroid hormone replacement in patients with CHT with that of patients with PHT. In addition, we explored and compared quality of life (QoL) between both groups, based on two questionnaires, the SF-36 health score and the thyroid-specific ThyPRO score. Methods: This is a monocentric, cross-sectional study, performed at the Ghent University Hospital (Belgium). We included 82 patients in total, 41 patients with CHT and 41 patients with PHT. At the time of inclusion, all patients had to have a stable dose of levothyroxine over the past 6 months and patients with PHT needed to be euthy roid (defined as having a thyroid-stimulating hormone level within the reference range, 0.2–4.5 mU/L). All data were retrieved from medical files, and questionnaires on QoL wer e self-administered. Results: The CHT and PHT groups were comparable regarding age and BMI. There was no significant difference between both groups regarding total daily dose of levothyroxine (100 (93.75–125.00) vs 107.14 (75.00–133.93) μg in CHT and PHT, respectively; P = 0.87) or daily dose of levothyroxine per kg body weight (1.34 (1.16–1.55 ) vs 1.55 (1.16–1.82) μg/kg, respectively; P = 0.13). Serum levels of fT4 (P = 0.20) and fT3 (P = 0.10) also did not differ between the two groups and both were in the normal (mid)range for the two groups. Regarding QoL, patients with CHT scored worse in terms of depressive and emotional symptoms, impaired daily and social life. Conclusion: We could demonstrate a difference in QoL between patients with CHT and PHT. Although patients with CHT had a somewhat lower levothyroxine substitution dose than patients with PHT, this difference was also not significant and probably does not explain the difference in QoL.https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-21-0128.xmlhypothyroidismpituitaryhypopituitarismhormonal substitutionthyroid |
| spellingShingle | Joke Marlier Guy T’Sjoen Jean Kaufman Bruno Lapauw papillary thyroid carcinoma European Thyroid Journal hypothyroidism pituitary hypopituitarism hormonal substitution thyroid |
| title | papillary thyroid carcinoma |
| title_full | papillary thyroid carcinoma |
| title_fullStr | papillary thyroid carcinoma |
| title_full_unstemmed | papillary thyroid carcinoma |
| title_short | papillary thyroid carcinoma |
| title_sort | papillary thyroid carcinoma |
| topic | hypothyroidism pituitary hypopituitarism hormonal substitution thyroid |
| url | https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-21-0128.xml |
| work_keys_str_mv | AT jokemarlier papillarythyroidcarcinoma AT guytsjoen papillarythyroidcarcinoma AT jeankaufman papillarythyroidcarcinoma AT brunolapauw papillarythyroidcarcinoma |