Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review
Preliminary evidence supports the use of psychedelics for major depressive disorder (MDD). However, less attention has been given to the neural mechanisms behind their effects. We conducted a systematic review examining the neuroimaging correlates of antidepressant response following psychedelic int...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2022-07-01
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| Series: | Chronic Stress |
| Online Access: | https://doi.org/10.1177/24705470221115342 |
| _version_ | 1811265193006596096 |
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| author | Sarah Kuburi Anne-Marie Di Passa Vanessa K. Tassone Raesham Mahmood Aleksandra Lalovic Karim S. Ladha Katharine Dunlop Sakina Rizvi Ilya Demchenko Venkat Bhat |
| author_facet | Sarah Kuburi Anne-Marie Di Passa Vanessa K. Tassone Raesham Mahmood Aleksandra Lalovic Karim S. Ladha Katharine Dunlop Sakina Rizvi Ilya Demchenko Venkat Bhat |
| author_sort | Sarah Kuburi |
| collection | DOAJ |
| description | Preliminary evidence supports the use of psychedelics for major depressive disorder (MDD). However, less attention has been given to the neural mechanisms behind their effects. We conducted a systematic review examining the neuroimaging correlates of antidepressant response following psychedelic interventions for MDD. Through MEDLINE, Embase, and APA PsycINFO, 187 records were identified and 42 articles were screened. Six published studies and one conference abstract were included. Five ongoing trials were included from ClinicalTrials.gov. Our search covered several psychedelics, though included studies were specific to psilocybin, ayahuasca, and lysergic acid diethylamide. Three psilocybin studies noted amygdala activity and functional connectivity (FC) alterations that correlated with treatment response. Two psilocybin studies reported that FC changes in the medial and ventromedial prefrontal cortices correlated with treatment response. Two trials from a single study reported global decreases in brain network modularity which correlated with antidepressant response. One ayahuasca study reported increased activity in the limbic regions following treatment. Preliminary evidence suggests that the default mode and limbic networks may be a target for future research on the neural mechanisms of psychedelics. More data is required to corroborate these initial findings as the evidence summarized in this review is based on four datasets. |
| first_indexed | 2024-04-12T20:18:01Z |
| format | Article |
| id | doaj.art-54c8022031ca41e8a6fa9394db1b9f42 |
| institution | Directory Open Access Journal |
| issn | 2470-5470 |
| language | English |
| last_indexed | 2024-04-12T20:18:01Z |
| publishDate | 2022-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Chronic Stress |
| spelling | doaj.art-54c8022031ca41e8a6fa9394db1b9f422022-12-22T03:18:04ZengSAGE PublishingChronic Stress2470-54702022-07-01610.1177/24705470221115342Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic ReviewSarah Kuburi0Anne-Marie Di Passa1Vanessa K. Tassone2Raesham Mahmood3Aleksandra Lalovic4Karim S. Ladha5Katharine Dunlop6Sakina Rizvi7Ilya Demchenko8Venkat Bhat9 Interventional Psychiatry Program, Mental Health and Addictions Service, St. Michael’s Hospital, 193 Yonge Street 6-013, M5B 1M8, Toronto, Ontario, Canada Interventional Psychiatry Program, Mental Health and Addictions Service, St. Michael’s Hospital, 193 Yonge Street 6-013, M5B 1M8, Toronto, Ontario, Canada Interventional Psychiatry Program, Mental Health and Addictions Service, St. Michael’s Hospital, 193 Yonge Street 6-013, M5B 1M8, Toronto, Ontario, Canada Institute of Medical Science, Faculty of Medicine, , 1 King's College Circle, Medical Sciences Building, M5S 1A8, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, M5B 1T8, Toronto, Ontario, Canada Department of Anesthesia, St. Michael's Hospital, 193 Yonge Street 6-013, M5B 1M8, Toronto, Ontario, Canada Keenan Research Center for Biomedical Science, St. Michael’s Hospital, Unity Health Toronto, 30 Bond Street, M5B 1W8, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, M5B 1T8, Toronto, Ontario, Canada Interventional Psychiatry Program, Mental Health and Addictions Service, St. Michael’s Hospital, 193 Yonge Street 6-013, M5B 1M8, Toronto, Ontario, Canada Li Ka Shing Knowledge Institute, St. Michael’s Hospital, 209 Victoria Street, M5B 1T8, Toronto, Ontario, CanadaPreliminary evidence supports the use of psychedelics for major depressive disorder (MDD). However, less attention has been given to the neural mechanisms behind their effects. We conducted a systematic review examining the neuroimaging correlates of antidepressant response following psychedelic interventions for MDD. Through MEDLINE, Embase, and APA PsycINFO, 187 records were identified and 42 articles were screened. Six published studies and one conference abstract were included. Five ongoing trials were included from ClinicalTrials.gov. Our search covered several psychedelics, though included studies were specific to psilocybin, ayahuasca, and lysergic acid diethylamide. Three psilocybin studies noted amygdala activity and functional connectivity (FC) alterations that correlated with treatment response. Two psilocybin studies reported that FC changes in the medial and ventromedial prefrontal cortices correlated with treatment response. Two trials from a single study reported global decreases in brain network modularity which correlated with antidepressant response. One ayahuasca study reported increased activity in the limbic regions following treatment. Preliminary evidence suggests that the default mode and limbic networks may be a target for future research on the neural mechanisms of psychedelics. More data is required to corroborate these initial findings as the evidence summarized in this review is based on four datasets.https://doi.org/10.1177/24705470221115342 |
| spellingShingle | Sarah Kuburi Anne-Marie Di Passa Vanessa K. Tassone Raesham Mahmood Aleksandra Lalovic Karim S. Ladha Katharine Dunlop Sakina Rizvi Ilya Demchenko Venkat Bhat Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review Chronic Stress |
| title | Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review |
| title_full | Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review |
| title_fullStr | Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review |
| title_full_unstemmed | Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review |
| title_short | Neuroimaging Correlates of Treatment Response with Psychedelics in Major Depressive Disorder: A Systematic Review |
| title_sort | neuroimaging correlates of treatment response with psychedelics in major depressive disorder a systematic review |
| url | https://doi.org/10.1177/24705470221115342 |
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