Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation

Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation

Zebrafish (Danio rerio) assays provide a versatile pharmacological platform to test compounds on a wide range of behaviors in a whole organism. A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of bioactive compounds in this model organism. Here, w...

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Bibliographic Details
Main Authors: Adrianna Skiba, Daniele Pellegata, Veronika Morozova, Ewelina Kozioł, Barbara Budzyńska, Simon Ming-Yuen Lee, Jürg Gertsch, Krystyna Skalicka-Woźniak
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Cells
Subjects:
pharmacokinetics
epilepsy
LC-MS analytics
valproate
amino acids
metabolomics
Online Access:https://www.mdpi.com/2073-4409/12/11/1540

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