Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals
PACAP was discovered 30 years ago in Dr. Akira Arimura's laboratory. In the past three decades since then, it has become evident that this peptide plays numerous crucial roles in mammalian organisms. The most important functions of PACAP are the following: 1. neurotransmitter, 2. neuromodulator...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-03-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00088/full |
| _version_ | 1818179455271567360 |
|---|---|
| author | Katalin Köves Enikő Szabó Orsolya Kántor Andrea Heinzlmann Flóra Szabó Ágnes Csáki |
| author_facet | Katalin Köves Enikő Szabó Orsolya Kántor Andrea Heinzlmann Flóra Szabó Ágnes Csáki |
| author_sort | Katalin Köves |
| collection | DOAJ |
| description | PACAP was discovered 30 years ago in Dr. Akira Arimura's laboratory. In the past three decades since then, it has become evident that this peptide plays numerous crucial roles in mammalian organisms. The most important functions of PACAP are the following: 1. neurotransmitter, 2. neuromodulator, 3. hypophysiotropic hormone, 4. neuroprotector. This paper reviews the accumulated data regarding the distribution of PACAP and its receptors in the mammalian hypothalamus and pituitary gland, the role of PACAP in the gonadotropin hormone secretion of females and males. The review also summarizes the interaction between PACAP, GnRH, and sex steroids as well as hypothalamic peptides including kisspeptin. The possible role of PACAP in reproductive functions through the biological clock is also discussed. Finally, the significance of PACAP in the hypothalamo-hypophysial system is considered and the facts missing, that would help better understand the function of PACAP in this system, are also highlighted. |
| first_indexed | 2024-12-11T21:04:09Z |
| format | Article |
| id | doaj.art-54c9403c8ef749b4a4ed0a626e52ca55 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-11T21:04:09Z |
| publishDate | 2020-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-54c9403c8ef749b4a4ed0a626e52ca552022-12-22T00:50:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-03-011110.3389/fendo.2020.00088506309Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of MammalsKatalin Köves0Enikő Szabó1Orsolya Kántor2Andrea Heinzlmann3Flóra Szabó4Ágnes Csáki5Department of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, HungaryDepartment of Conservative Dentistry, Faculty of Dentistry, Semmelweis University, Budapest, HungaryDepartment of Molecular Embryology, Medical Faculty, Institute of Anatomy and Cell Biology, University of Freiburg, Freiburg, GermanyDepartment of Anatomy and Histology, University of Veterinary Sciences, Budapest, HungaryDepartment of Pediatrics, Virginia Commonwealth University, Richmond, VA, United StatesDepartment of Anatomy, Histology and Embryology, Faculty of Medicine, Semmelweis University, Budapest, HungaryPACAP was discovered 30 years ago in Dr. Akira Arimura's laboratory. In the past three decades since then, it has become evident that this peptide plays numerous crucial roles in mammalian organisms. The most important functions of PACAP are the following: 1. neurotransmitter, 2. neuromodulator, 3. hypophysiotropic hormone, 4. neuroprotector. This paper reviews the accumulated data regarding the distribution of PACAP and its receptors in the mammalian hypothalamus and pituitary gland, the role of PACAP in the gonadotropin hormone secretion of females and males. The review also summarizes the interaction between PACAP, GnRH, and sex steroids as well as hypothalamic peptides including kisspeptin. The possible role of PACAP in reproductive functions through the biological clock is also discussed. Finally, the significance of PACAP in the hypothalamo-hypophysial system is considered and the facts missing, that would help better understand the function of PACAP in this system, are also highlighted.https://www.frontiersin.org/article/10.3389/fendo.2020.00088/fullPACAPreproductionmammalsmalefemale |
| spellingShingle | Katalin Köves Enikő Szabó Orsolya Kántor Andrea Heinzlmann Flóra Szabó Ágnes Csáki Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals Frontiers in Endocrinology PACAP reproduction mammals male female |
| title | Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals |
| title_full | Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals |
| title_fullStr | Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals |
| title_full_unstemmed | Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals |
| title_short | Current State of Understanding of the Role of PACAP in the Hypothalamo-Hypophyseal Gonadotropin Functions of Mammals |
| title_sort | current state of understanding of the role of pacap in the hypothalamo hypophyseal gonadotropin functions of mammals |
| topic | PACAP reproduction mammals male female |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00088/full |
| work_keys_str_mv | AT katalinkoves currentstateofunderstandingoftheroleofpacapinthehypothalamohypophysealgonadotropinfunctionsofmammals AT enikoszabo currentstateofunderstandingoftheroleofpacapinthehypothalamohypophysealgonadotropinfunctionsofmammals AT orsolyakantor currentstateofunderstandingoftheroleofpacapinthehypothalamohypophysealgonadotropinfunctionsofmammals AT andreaheinzlmann currentstateofunderstandingoftheroleofpacapinthehypothalamohypophysealgonadotropinfunctionsofmammals AT floraszabo currentstateofunderstandingoftheroleofpacapinthehypothalamohypophysealgonadotropinfunctionsofmammals AT agnescsaki currentstateofunderstandingoftheroleofpacapinthehypothalamohypophysealgonadotropinfunctionsofmammals |