Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects
Purpose. The purpose of this study was to investigate the utility of steady state pattern electroretinogram (ss-PERG) in detecting retinal ganglion cell (RGC) dysfunction in glaucoma suspects (GS) who had normal 24-2 Humphrey Visual Fields (HFA). Materials and Methods. This was a prospective cohort...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
|
| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2024/2443887 |
| _version_ | 1827077565485940736 |
|---|---|
| author | Andrew Tirsi Vasiliki Gliagias Daniel Zhu Benny Wong Rohun Gupta Sung Chul Park Stephen Obstbaum Celso Tello |
| author_facet | Andrew Tirsi Vasiliki Gliagias Daniel Zhu Benny Wong Rohun Gupta Sung Chul Park Stephen Obstbaum Celso Tello |
| author_sort | Andrew Tirsi |
| collection | DOAJ |
| description | Purpose. The purpose of this study was to investigate the utility of steady state pattern electroretinogram (ss-PERG) in detecting retinal ganglion cell (RGC) dysfunction in glaucoma suspects (GS) who had normal 24-2 Humphrey Visual Fields (HFA). Materials and Methods. This was a prospective cohort study of GS patients who were identified based on optic disc appearance with normal HFAs. Patients received a complete eye examination, standard automated perimetry (SAP), optical coherence tomography (OCT), and ss-PERG measurements. The ss-PERG parameters, Magnitude (Mag), Magnitude D (MagD), and MagD/Mag ratio, were examined, along with their relationships between HFA and OCT measurements. Results. Twenty-five patients were included in this study, with a total of 49 eyes. Fifteen eyes had abnormal ss-PERG parameters and when compared to GS eyes with normal ss-PERG parameters, there were significant differences in HFA 24-2, retinal nerve fiber layer (RNFL) thickness, and ganglion cell layer and inner plexiform layer (GCL + IPL) thickness. All ss-PERG parameters were significantly correlated with 24-2 VF mean deviation (MD) and visual field index (VFI), as well as 10-2 VF MD after controlling for age, sex, intraocular pressure, central corneal thickness, and spherical equivalent. When controlled for age, spherical equivalent, and IOP, MagD/Mag ratio significantly contributed to the variance in average GCL + IPL thicknesses, whereas 24-2 VF MD and 10-2 VF MD did not. MagD/Mag ratio also significantly accounted for variance in all macular GCL + IPL sectors, while 10-2 VF MD did not. Conclusions. ss-PERG has significant correlations with HFA global indices and was predictive of GCL + IPL thickness in GS patients. Clinical Significance. ss-PERG may serve as a useful functional tool for detecting and measuring RGC dysfunction in GS. It appears to be more sensitive than HFA in the detection of early changes in GCL + IPL thicknesses and may be helpful to use in conjunction with current diagnostic studies to improve the ability of monitoring GS progression. |
| first_indexed | 2024-04-24T22:42:28Z |
| format | Article |
| id | doaj.art-54c95cf6a6464f51ba20208e5dc6aa74 |
| institution | Directory Open Access Journal |
| issn | 2090-0058 |
| language | English |
| last_indexed | 2025-03-20T02:15:48Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-54c95cf6a6464f51ba20208e5dc6aa742024-10-03T07:51:07ZengHindawi LimitedJournal of Ophthalmology2090-00582024-01-01202410.1155/2024/2443887Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma SuspectsAndrew Tirsi0Vasiliki Gliagias1Daniel Zhu2Benny Wong3Rohun Gupta4Sung Chul Park5Stephen Obstbaum6Celso Tello7Manhattan Eye, Ear and Throat HospitalNorthwell HealthManhattan Eye, Ear and Throat HospitalManhattan Eye, Ear and Throat HospitalDonald and Barbara Zucker School of Medicine at Hofstra University/Northwell HealthManhattan Eye, Ear and Throat HospitalManhattan Eye, Ear and Throat HospitalManhattan Eye, Ear and Throat HospitalPurpose. The purpose of this study was to investigate the utility of steady state pattern electroretinogram (ss-PERG) in detecting retinal ganglion cell (RGC) dysfunction in glaucoma suspects (GS) who had normal 24-2 Humphrey Visual Fields (HFA). Materials and Methods. This was a prospective cohort study of GS patients who were identified based on optic disc appearance with normal HFAs. Patients received a complete eye examination, standard automated perimetry (SAP), optical coherence tomography (OCT), and ss-PERG measurements. The ss-PERG parameters, Magnitude (Mag), Magnitude D (MagD), and MagD/Mag ratio, were examined, along with their relationships between HFA and OCT measurements. Results. Twenty-five patients were included in this study, with a total of 49 eyes. Fifteen eyes had abnormal ss-PERG parameters and when compared to GS eyes with normal ss-PERG parameters, there were significant differences in HFA 24-2, retinal nerve fiber layer (RNFL) thickness, and ganglion cell layer and inner plexiform layer (GCL + IPL) thickness. All ss-PERG parameters were significantly correlated with 24-2 VF mean deviation (MD) and visual field index (VFI), as well as 10-2 VF MD after controlling for age, sex, intraocular pressure, central corneal thickness, and spherical equivalent. When controlled for age, spherical equivalent, and IOP, MagD/Mag ratio significantly contributed to the variance in average GCL + IPL thicknesses, whereas 24-2 VF MD and 10-2 VF MD did not. MagD/Mag ratio also significantly accounted for variance in all macular GCL + IPL sectors, while 10-2 VF MD did not. Conclusions. ss-PERG has significant correlations with HFA global indices and was predictive of GCL + IPL thickness in GS patients. Clinical Significance. ss-PERG may serve as a useful functional tool for detecting and measuring RGC dysfunction in GS. It appears to be more sensitive than HFA in the detection of early changes in GCL + IPL thicknesses and may be helpful to use in conjunction with current diagnostic studies to improve the ability of monitoring GS progression.http://dx.doi.org/10.1155/2024/2443887 |
| spellingShingle | Andrew Tirsi Vasiliki Gliagias Daniel Zhu Benny Wong Rohun Gupta Sung Chul Park Stephen Obstbaum Celso Tello Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects Journal of Ophthalmology |
| title | Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects |
| title_full | Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects |
| title_fullStr | Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects |
| title_full_unstemmed | Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects |
| title_short | Correlations between Steady-State Pattern Electroretinogram and Humphrey Visual Field Analyzer Global Indices and Their Associations with Retinal Ganglion Cell Layer-Inner Plexiform Layer Thickness in Glaucoma Suspects |
| title_sort | correlations between steady state pattern electroretinogram and humphrey visual field analyzer global indices and their associations with retinal ganglion cell layer inner plexiform layer thickness in glaucoma suspects |
| url | http://dx.doi.org/10.1155/2024/2443887 |
| work_keys_str_mv | AT andrewtirsi correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT vasilikigliagias correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT danielzhu correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT bennywong correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT rohungupta correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT sungchulpark correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT stephenobstbaum correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects AT celsotello correlationsbetweensteadystatepatternelectroretinogramandhumphreyvisualfieldanalyzerglobalindicesandtheirassociationswithretinalganglioncelllayerinnerplexiformlayerthicknessinglaucomasuspects |