Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern
Canine monocytic ehrlichiosis (CME) is endemic to Brazil, and studies have verified that dogs have been exposed to different genotypes of <i>Ehrlichia canis</i>. This genetic divergence can influence the clinical response of the animals. We aimed to describe clinical and hematological ch...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/10/5/316 |
| _version_ | 1827739882226712576 |
|---|---|
| author | Karla Irigaray Nogueira Borges Nathalia de Assis Pereira Daniel Moura de Aguiar Isis Indaiara Gonçalves Granjeiro Taques Bruna Samara Alves-Ribeiro Dirceu Guilherme de Souza Ramos Ísis Assis Braga |
| author_facet | Karla Irigaray Nogueira Borges Nathalia de Assis Pereira Daniel Moura de Aguiar Isis Indaiara Gonçalves Granjeiro Taques Bruna Samara Alves-Ribeiro Dirceu Guilherme de Souza Ramos Ísis Assis Braga |
| author_sort | Karla Irigaray Nogueira Borges |
| collection | DOAJ |
| description | Canine monocytic ehrlichiosis (CME) is endemic to Brazil, and studies have verified that dogs have been exposed to different genotypes of <i>Ehrlichia canis</i>. This genetic divergence can influence the clinical response of the animals. We aimed to describe clinical and hematological changes in 125 dogs that reacted to BrTRP36, USTRP36, and CRTRP36 genotypes through enzyme immunoassays and to highlight the current concern regarding infection by the Costa Rican genotype. The results showed that 52.0% reacted to the Brazilian genotype, 22.4% reacted to the Costa Rican genotype, and 16.0% reacted to the American genotype, and some co-reactions were observed. Dogs reactive to BrTRP36 were 1.24% more likely to present with medullary regeneration in cases of anemia and 3% less likely to manifest hyperproteinemia, while dogs reactive to CRTRP36 were 0.7% less likely to present with medullary regeneration. Febrile illness and neurological alterations were also statistically associated, with an 85.7% and 231.2% increased likelihood, respectively, to occur in dogs that reacted to USTRP36. The dogs with the American genotype developed clinical manifestations related to systemic inflammation, while those with the Brazilian genotype of <i>E. canis</i> were more dispersed in the region studied, showing greater adaptation to the hosts. We highlight the significant serocurrence of the Costa Rican genotype, which has already been described to have zoonotic potential and which showed less adaptation. |
| first_indexed | 2024-03-11T03:14:20Z |
| format | Article |
| id | doaj.art-54c9ee1bf8824bd2bfd94aa94f59c841 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T03:14:20Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-54c9ee1bf8824bd2bfd94aa94f59c8412023-11-18T03:37:13ZengMDPI AGVeterinary Sciences2306-73812023-04-0110531610.3390/vetsci10050316Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current ConcernKarla Irigaray Nogueira Borges0Nathalia de Assis Pereira1Daniel Moura de Aguiar2Isis Indaiara Gonçalves Granjeiro Taques3Bruna Samara Alves-Ribeiro4Dirceu Guilherme de Souza Ramos5Ísis Assis Braga6Veterinary Medicine College, Basic Unit of Bioscience, Mineiros University Center, 22nd Street s/n, Mineiros 75833-130, GO, BrazilVirology and Rickettsioses Laboratory, Department of Clinical Veterinary Medicine, Veterinary Medicine College, Federal University of Mato Grosso, Fernando Correa da Costa Avenue 2367, Cuiabá 78060-900, MT, BrazilVirology and Rickettsioses Laboratory, Department of Clinical Veterinary Medicine, Veterinary Medicine College, Federal University of Mato Grosso, Fernando Correa da Costa Avenue 2367, Cuiabá 78060-900, MT, BrazilEDUVALE College—Campus Jaciara, Caiçara Street, 2.114, Jaciara 78820-000, MT, BrazilLaboratory of Veterinary Pathology and Parasitology, Academic Unit of Agricultural Sciences, Federal University of Jataí, Jataí 75801-615, GO, BrazilLaboratory of Veterinary Pathology and Parasitology, Academic Unit of Agricultural Sciences, Federal University of Jataí, Jataí 75801-615, GO, BrazilVeterinary Medicine College, Basic Unit of Bioscience, Mineiros University Center, 22nd Street s/n, Mineiros 75833-130, GO, BrazilCanine monocytic ehrlichiosis (CME) is endemic to Brazil, and studies have verified that dogs have been exposed to different genotypes of <i>Ehrlichia canis</i>. This genetic divergence can influence the clinical response of the animals. We aimed to describe clinical and hematological changes in 125 dogs that reacted to BrTRP36, USTRP36, and CRTRP36 genotypes through enzyme immunoassays and to highlight the current concern regarding infection by the Costa Rican genotype. The results showed that 52.0% reacted to the Brazilian genotype, 22.4% reacted to the Costa Rican genotype, and 16.0% reacted to the American genotype, and some co-reactions were observed. Dogs reactive to BrTRP36 were 1.24% more likely to present with medullary regeneration in cases of anemia and 3% less likely to manifest hyperproteinemia, while dogs reactive to CRTRP36 were 0.7% less likely to present with medullary regeneration. Febrile illness and neurological alterations were also statistically associated, with an 85.7% and 231.2% increased likelihood, respectively, to occur in dogs that reacted to USTRP36. The dogs with the American genotype developed clinical manifestations related to systemic inflammation, while those with the Brazilian genotype of <i>E. canis</i> were more dispersed in the region studied, showing greater adaptation to the hosts. We highlight the significant serocurrence of the Costa Rican genotype, which has already been described to have zoonotic potential and which showed less adaptation.https://www.mdpi.com/2306-7381/10/5/316<i>Ehrlichia canis</i>BrTRP36CRTRP36USTRP36immune adaptationzoonotic potential |
| spellingShingle | Karla Irigaray Nogueira Borges Nathalia de Assis Pereira Daniel Moura de Aguiar Isis Indaiara Gonçalves Granjeiro Taques Bruna Samara Alves-Ribeiro Dirceu Guilherme de Souza Ramos Ísis Assis Braga Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern Veterinary Sciences <i>Ehrlichia canis</i> BrTRP36 CRTRP36 USTRP36 immune adaptation zoonotic potential |
| title | Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern |
| title_full | Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern |
| title_fullStr | Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern |
| title_full_unstemmed | Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern |
| title_short | Costa Rican Genotype of <i>Ehrlichia canis</i>: A Current Concern |
| title_sort | costa rican genotype of i ehrlichia canis i a current concern |
| topic | <i>Ehrlichia canis</i> BrTRP36 CRTRP36 USTRP36 immune adaptation zoonotic potential |
| url | https://www.mdpi.com/2306-7381/10/5/316 |
| work_keys_str_mv | AT karlairigaraynogueiraborges costaricangenotypeofiehrlichiacanisiacurrentconcern AT nathaliadeassispereira costaricangenotypeofiehrlichiacanisiacurrentconcern AT danielmouradeaguiar costaricangenotypeofiehrlichiacanisiacurrentconcern AT isisindaiaragoncalvesgranjeirotaques costaricangenotypeofiehrlichiacanisiacurrentconcern AT brunasamaraalvesribeiro costaricangenotypeofiehrlichiacanisiacurrentconcern AT dirceuguilhermedesouzaramos costaricangenotypeofiehrlichiacanisiacurrentconcern AT isisassisbraga costaricangenotypeofiehrlichiacanisiacurrentconcern |