Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft
This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery. Patients were assigned for surgery with CAG (group A), mPRGF (group B), or...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
|
| Series: | Journal of Clinical Medicine |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2077-0383/10/23/5711 |
| _version_ | 1797507566152974336 |
|---|---|
| author | Miriam Idoipe Borja de la Sen-Corcuera Ronald M. Sánchez-Ávila Carmen Sánchez-Pérez María Satué Antonio Sánchez-Pérez Gorka Orive Francisco Muruzabal Eduardo Anitua Luis Pablo |
| author_facet | Miriam Idoipe Borja de la Sen-Corcuera Ronald M. Sánchez-Ávila Carmen Sánchez-Pérez María Satué Antonio Sánchez-Pérez Gorka Orive Francisco Muruzabal Eduardo Anitua Luis Pablo |
| author_sort | Miriam Idoipe |
| collection | DOAJ |
| description | This prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery. Patients were assigned for surgery with CAG (group A), mPRGF (group B), or AMT (group C). Pterygium recurrence, Best Corrected Visual Acuity (BCVA), graft size (measured with anterior segment optical coherence tomography (AS-OCT)), and ocular surface symptoms (visual analogue scale (VAS) and ocular surface disease index (OSDI)) were evaluated. Thirteen eyes in group A, 26 in group B, and 10 in group C were evaluated. No changes in BCVA (<i>p</i> > 0.05) were found. Recurrence cases for groups A, B, and C were none, two, and two, respectively, and three cases of pyogenic granulomas in group A. The horizontal/vertical graft size was lower in group B vs group A (<i>p</i> < 0.05) from months 1 to 12. The improvement in VAS frequency for groups A, B, and C was: 35.5%, 86.2%, and 39.1%, respectively. The OSDI scale reduction for groups A, B, and C was: 12.7%, 39.0%, and 84.1%. The use of the three surgical techniques as a graft for primary pterygium surgery was safe and effective, showing similar results. The mPRGF graft represents an autologous novel approach for pterygium surgery. |
| first_indexed | 2024-03-10T04:50:14Z |
| format | Article |
| id | doaj.art-54ca3105206a41c1a5e709bc97577c1f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T04:50:14Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-54ca3105206a41c1a5e709bc97577c1f2023-11-23T02:38:15ZengMDPI AGJournal of Clinical Medicine2077-03832021-12-011023571110.3390/jcm10235711Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival AutograftMiriam Idoipe0Borja de la Sen-Corcuera1Ronald M. Sánchez-Ávila2Carmen Sánchez-Pérez3María Satué4Antonio Sánchez-Pérez5Gorka Orive6Francisco Muruzabal7Eduardo Anitua8Luis Pablo9Ophthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainRegenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, SpainRegenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, SpainOphthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainOphthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainRegenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, SpainRegenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, SpainRegenerative Medicine Laboratory, Biotechnology Institute (BTI), 01007 Vitoria, SpainOphthalmology Department, Miguel Servet University Hospital, 50009 Zaragoza, SpainThis prospective and comparative study aimed to compare the use of a conjunctival autograft (CAG), plasma rich in growth factors fibrin membrane (mPRGF) or amniotic membrane transplantation (AMT) in primary pterygium surgery. Patients were assigned for surgery with CAG (group A), mPRGF (group B), or AMT (group C). Pterygium recurrence, Best Corrected Visual Acuity (BCVA), graft size (measured with anterior segment optical coherence tomography (AS-OCT)), and ocular surface symptoms (visual analogue scale (VAS) and ocular surface disease index (OSDI)) were evaluated. Thirteen eyes in group A, 26 in group B, and 10 in group C were evaluated. No changes in BCVA (<i>p</i> > 0.05) were found. Recurrence cases for groups A, B, and C were none, two, and two, respectively, and three cases of pyogenic granulomas in group A. The horizontal/vertical graft size was lower in group B vs group A (<i>p</i> < 0.05) from months 1 to 12. The improvement in VAS frequency for groups A, B, and C was: 35.5%, 86.2%, and 39.1%, respectively. The OSDI scale reduction for groups A, B, and C was: 12.7%, 39.0%, and 84.1%. The use of the three surgical techniques as a graft for primary pterygium surgery was safe and effective, showing similar results. The mPRGF graft represents an autologous novel approach for pterygium surgery.https://www.mdpi.com/2077-0383/10/23/5711PRGFpterygium surgeryamniotic membrane transplantationconjunctival autograftPRPplasma rich in growth factors |
| spellingShingle | Miriam Idoipe Borja de la Sen-Corcuera Ronald M. Sánchez-Ávila Carmen Sánchez-Pérez María Satué Antonio Sánchez-Pérez Gorka Orive Francisco Muruzabal Eduardo Anitua Luis Pablo Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft Journal of Clinical Medicine PRGF pterygium surgery amniotic membrane transplantation conjunctival autograft PRP plasma rich in growth factors |
| title | Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft |
| title_full | Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft |
| title_fullStr | Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft |
| title_full_unstemmed | Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft |
| title_short | Membrane of Plasma Rich in Growth Factors in Primary Pterygium Surgery Compared to Amniotic Membrane Transplantation and Conjunctival Autograft |
| title_sort | membrane of plasma rich in growth factors in primary pterygium surgery compared to amniotic membrane transplantation and conjunctival autograft |
| topic | PRGF pterygium surgery amniotic membrane transplantation conjunctival autograft PRP plasma rich in growth factors |
| url | https://www.mdpi.com/2077-0383/10/23/5711 |
| work_keys_str_mv | AT miriamidoipe membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT borjadelasencorcuera membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT ronaldmsanchezavila membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT carmensanchezperez membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT mariasatue membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT antoniosanchezperez membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT gorkaorive membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT franciscomuruzabal membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT eduardoanitua membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft AT luispablo membraneofplasmarichingrowthfactorsinprimarypterygiumsurgerycomparedtoamnioticmembranetransplantationandconjunctivalautograft |