What regulates hepcidin in poly-transfused β-Thalassemia Major: Erythroid drive or store drive?

What regulates hepcidin in poly-transfused β-Thalassemia Major: Erythroid drive or store drive?

Background: Hepcidin, a key regulator of iron homeostasis, is increased by iron overload and inflammation while suppressed by hypoxia. In spite of iron overload in β-Thalassemia Major (β-TM), a paradoxical decrease in hepcidin is observed. Aim: To assess the opposing effects of enhanced erythropoies...

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Bibliographic Details
Main Authors: Richa Chauhan, Sunita Sharma, Jagdish Chandra
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2014-01-01
Series:Indian Journal of Pathology and Microbiology
Subjects:
β-Thalassemia
hepcidin
iron overload
Online Access:http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2014;volume=57;issue=1;spage=39;epage=42;aulast=Chauhan

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