Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine
Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light and sound) has been extensively reported. However, migraine may feature a more general enhanced response to aversiv...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-07-01
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| Series: | Frontiers in Human Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00366/full |
| _version_ | 1818328448995688448 |
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| author | Sophie Louise Wilcox Rosanna Veggeberg Jordan Lemme Duncan Hodkinson Steven Scrivani Rami Burstein Lino Becerra David Borsook |
| author_facet | Sophie Louise Wilcox Rosanna Veggeberg Jordan Lemme Duncan Hodkinson Steven Scrivani Rami Burstein Lino Becerra David Borsook |
| author_sort | Sophie Louise Wilcox |
| collection | DOAJ |
| description | Pain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light and sound) has been extensively reported. However, migraine may feature a more general enhanced response to aversive stimuli rather than being sensory-specific. To this end we used functional magnetic resonance imaging to assess neural activation in migraineurs interictaly in response to emotional visual stimuli from the International Affective Picture System. Migraineurs, compared to healthy controls, demonstrated increased neural activity in response to negative emotional stimuli. Most notably in regions overlapping in their involvement in both nociceptive and emotional processing including the posterior cingulate, caudate, amygdala and thalamus (cluster corrected, p<0.01). In contrast, migraineurs and healthy controls displayed no and minimal differences in response to positive and neutral emotional stimuli, respectively. These findings support the notion that migraine may feature more generalized altered cerebral processing of aversive/negative stimuli, rather than exclusively to sensory stimuli. A generalized hypersensitivity to aversive stimuli may be an inherent feature of migraine, or a consequential alteration developed over the duration of the disease. This proposed cortical-limbic hypersensitivity may form an important part of the migraine pathophysiology, including psychological comorbidity, and may represent an innate sensitivity to aversive stimuli that underpins attack triggers, attack persistence and (potentially) gradual headache chronification. |
| first_indexed | 2024-12-13T12:32:20Z |
| format | Article |
| id | doaj.art-54cbf44a08f845c7b2a45d0a8935cf7e |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T12:32:20Z |
| publishDate | 2016-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-54cbf44a08f845c7b2a45d0a8935cf7e2022-12-21T23:46:00ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-07-011010.3389/fnhum.2016.00366205702Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in MigraineSophie Louise Wilcox0Rosanna Veggeberg1Jordan Lemme2Duncan Hodkinson3Steven Scrivani4Rami Burstein5Lino Becerra6David Borsook7Harvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolMassachusetts General HospitalHarvard Medical SchoolHarvard Medical SchoolHarvard Medical SchoolPain is both an unpleasant sensory and emotional experience. This is highly relevant in migraine where cortical hyperexcitability in response to sensory stimuli (including pain, light and sound) has been extensively reported. However, migraine may feature a more general enhanced response to aversive stimuli rather than being sensory-specific. To this end we used functional magnetic resonance imaging to assess neural activation in migraineurs interictaly in response to emotional visual stimuli from the International Affective Picture System. Migraineurs, compared to healthy controls, demonstrated increased neural activity in response to negative emotional stimuli. Most notably in regions overlapping in their involvement in both nociceptive and emotional processing including the posterior cingulate, caudate, amygdala and thalamus (cluster corrected, p<0.01). In contrast, migraineurs and healthy controls displayed no and minimal differences in response to positive and neutral emotional stimuli, respectively. These findings support the notion that migraine may feature more generalized altered cerebral processing of aversive/negative stimuli, rather than exclusively to sensory stimuli. A generalized hypersensitivity to aversive stimuli may be an inherent feature of migraine, or a consequential alteration developed over the duration of the disease. This proposed cortical-limbic hypersensitivity may form an important part of the migraine pathophysiology, including psychological comorbidity, and may represent an innate sensitivity to aversive stimuli that underpins attack triggers, attack persistence and (potentially) gradual headache chronification.http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00366/fullHeadacheemotionfMRILimbicMigraineIAPS |
| spellingShingle | Sophie Louise Wilcox Rosanna Veggeberg Jordan Lemme Duncan Hodkinson Steven Scrivani Rami Burstein Lino Becerra David Borsook Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine Frontiers in Human Neuroscience Headache emotion fMRI Limbic Migraine IAPS |
| title | Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine |
| title_full | Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine |
| title_fullStr | Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine |
| title_full_unstemmed | Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine |
| title_short | Increased Functional Activation of Limbic Brain Regions During Negative Emotional Processing in Migraine |
| title_sort | increased functional activation of limbic brain regions during negative emotional processing in migraine |
| topic | Headache emotion fMRI Limbic Migraine IAPS |
| url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2016.00366/full |
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