Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats

Catechol-o-methyltransferase inhibitor tolcapone improves learning and memory in naïve but not in haloperidol challenged rats

Objective(s): Dopamine plays an important role in cognitive functions. Inhibition of the dopamine-degrading enzyme catechol-O-methyltransferase (COMT) may have beneficial effects. Our aim was to assess the effect of COMT inhibitor tolcapone (TCP) on learning and memory in naïve and haloperidol-chall...

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Bibliographic Details
Main Authors: Anita Mihaylova, Hristina Zlatanova, Nina Doncheva, Delian Delev, Ilia Kostadinov
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2019-06-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
COMT
Dopamine
Hippocampus
Prefrontal cortex
Spatial Memory
Tolcapone
Working memory
Online Access:http://ijbms.mums.ac.ir/article_12772_6f563c6beb866d7ca985ae3cf4d7ddbc.pdf

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