Split hand phenomenon: An early marker for amyotrophic lateral sclerosis
Background: Amyotrophic lateral sclerosis (ALS) is a progressive disease characterized by degeneration of upper and lower motor neurons. Time from symptom onset to confirmed diagnosis has been reported from 8 to 15 months in ALS. Objectives: To describe the frequency of the split hand phenomenon and...
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Permanyer
2021-10-01
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| Series: | Revista Mexicana de Neurociencia |
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| Online Access: | https://www.revmexneurociencia.com/frame_esp.php?id=137 |
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| author | Javier A. Galnares-Olalde Juan C. López-Hernández Jorge de Saráchaga-Adib Roberto Cervantes-Uribe Edwin S. Vargas-Cañas |
| author_facet | Javier A. Galnares-Olalde Juan C. López-Hernández Jorge de Saráchaga-Adib Roberto Cervantes-Uribe Edwin S. Vargas-Cañas |
| author_sort | Javier A. Galnares-Olalde |
| collection | DOAJ |
| description | Background: Amyotrophic lateral sclerosis (ALS) is a progressive disease characterized by degeneration of upper and lower motor neurons. Time from symptom onset to confirmed diagnosis has been reported from 8 to 15 months in ALS. Objectives: To describe the frequency of the split hand phenomenon and propose it as an early biomarker for ALS diagnosis. Methods: A retrospective, analytical, descriptive, and single-center observational study was performed. The split hand ratio was determined by dividing distal abductor pollicis brevis/abductor digit minimi compound muscle action potentials; a result < 0.6 was considered present. Results: Fifty-four patients with ALS diagnosis were included in the study. The split hand ratio was identified in 61.5% of patients with definite ALS, in 68.7% with probable ALS, 80% with possible ALS, and in 50% with suspected ALS. The split hand phenomenon was identified in 60% of patients within 12 months of symptom onset. Conclusion: We provide evidence for an additional neurophysiological tool that helps early diagnosis of ALS. |
| first_indexed | 2024-12-14T01:34:37Z |
| format | Article |
| id | doaj.art-54cf5bc81d254267b600cdf2c0c60d4e |
| institution | Directory Open Access Journal |
| issn | 2604-6180 |
| language | English |
| last_indexed | 2024-12-14T01:34:37Z |
| publishDate | 2021-10-01 |
| publisher | Permanyer |
| record_format | Article |
| series | Revista Mexicana de Neurociencia |
| spelling | doaj.art-54cf5bc81d254267b600cdf2c0c60d4e2022-12-21T23:21:55ZengPermanyerRevista Mexicana de Neurociencia2604-61802021-10-0122410.24875/RMN.20000135Split hand phenomenon: An early marker for amyotrophic lateral sclerosisJavier A. Galnares-Olalde0Juan C. López-Hernández1Jorge de Saráchaga-Adib2Roberto Cervantes-Uribe3Edwin S. Vargas-Cañas4Department of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoDepartment of Neuromuscular Disease, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoDepartment of Neurology, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoDepartment of Neuromuscular Disease, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoDepartment of Neuromuscular Disease, Instituto Nacional de Neurología y Neurocirugía Manuel Velasco Suárez, Mexico City, MexicoBackground: Amyotrophic lateral sclerosis (ALS) is a progressive disease characterized by degeneration of upper and lower motor neurons. Time from symptom onset to confirmed diagnosis has been reported from 8 to 15 months in ALS. Objectives: To describe the frequency of the split hand phenomenon and propose it as an early biomarker for ALS diagnosis. Methods: A retrospective, analytical, descriptive, and single-center observational study was performed. The split hand ratio was determined by dividing distal abductor pollicis brevis/abductor digit minimi compound muscle action potentials; a result < 0.6 was considered present. Results: Fifty-four patients with ALS diagnosis were included in the study. The split hand ratio was identified in 61.5% of patients with definite ALS, in 68.7% with probable ALS, 80% with possible ALS, and in 50% with suspected ALS. The split hand phenomenon was identified in 60% of patients within 12 months of symptom onset. Conclusion: We provide evidence for an additional neurophysiological tool that helps early diagnosis of ALS.https://www.revmexneurociencia.com/frame_esp.php?id=137Amyotrophic lateral sclerosis. Motor neuron disease. Split hand phenomenon. El Escorial criteria. |
| spellingShingle | Javier A. Galnares-Olalde Juan C. López-Hernández Jorge de Saráchaga-Adib Roberto Cervantes-Uribe Edwin S. Vargas-Cañas Split hand phenomenon: An early marker for amyotrophic lateral sclerosis Revista Mexicana de Neurociencia Amyotrophic lateral sclerosis. Motor neuron disease. Split hand phenomenon. El Escorial criteria. |
| title | Split hand phenomenon: An early marker for amyotrophic lateral sclerosis |
| title_full | Split hand phenomenon: An early marker for amyotrophic lateral sclerosis |
| title_fullStr | Split hand phenomenon: An early marker for amyotrophic lateral sclerosis |
| title_full_unstemmed | Split hand phenomenon: An early marker for amyotrophic lateral sclerosis |
| title_short | Split hand phenomenon: An early marker for amyotrophic lateral sclerosis |
| title_sort | split hand phenomenon an early marker for amyotrophic lateral sclerosis |
| topic | Amyotrophic lateral sclerosis. Motor neuron disease. Split hand phenomenon. El Escorial criteria. |
| url | https://www.revmexneurociencia.com/frame_esp.php?id=137 |
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