Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors

Chemokine Receptor Expression on T Cells Is Modulated by CAFs and Chemokines Affect the Spatial Distribution of T Cells in Pancreatic Tumors

The accumulation of T cells is associated with a better prognosis in pancreatic cancer. However, the immunosuppressive tumor microenvironment, largely composed by cancer-associated fibroblasts (CAFs), can prevent T cells from reaching the tumor nests. We examined how human CAFs modulated chemokine r...

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Bibliographic Details
Main Authors: Laia Gorchs, Marlies Oosthoek, Tülay Yucel-Lindberg, Carlos Fernández Moro, Helen Kaipe
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cancers
Subjects:
pancreatic cancer
carcinoma-associated fibroblasts
CD4 T cells
CD8 T cells
chemokines
CXCR3
Online Access:https://www.mdpi.com/2072-6694/14/15/3826

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