Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Xenon treatment after severe traumatic brain injury improves locomotor outcome, reduces acute neuronal loss and enhances early beneficial neuroinflammation: a randomized, blinded, controlled animal study

Abstract Background Traumatic brain injury (TBI) is a major cause of morbidity and mortality, but there are no clinically proven treatments that specifically target neuronal loss and secondary injury development following TBI. In this study, we evaluate the effect of xenon treatment on functional ou...

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Bibliographic Details
Main Authors: Rita Campos-Pires, Haldis Onggradito, Eszter Ujvari, Shughoofa Karimi, Flavia Valeo, Jitka Aldhoun, Christopher J. Edge, Nicholas P. Franks, Robert Dickinson
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Critical Care
Subjects:
Xenon
Noble gases
Neuroprotection
Neurotrauma
Acquired brain injury
Neuroinflammation
Online Access:https://doi.org/10.1186/s13054-020-03373-9

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