CD28: Direct and Critical Receptor for Superantigen Toxins

CD28: Direct and Critical Receptor for Superantigen Toxins

Every adaptive immune response requires costimulation through the B7/CD28 axis, with CD28 on T-cells functioning as principal costimulatory receptor. Staphylococcal and streptococcal superantigen toxins hyperstimulate the T-cell-mediated immune response by orders of magnitude, inducing a lethal cyto...

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Bibliographic Details
Main Authors:	Ziv Rotfogel, Iris Nasie, Dalia Hillman, Revital Levy, Gila Arad, Raymond Kaempfer
Format:	Article
Language:	English
Published:	MDPI AG 2013-09-01
Series:	Toxins
Subjects:	superantigen toxins inflammatory cytokine storm lethal toxic shock biodefense CD28 receptor CD28 dimer interface
Online Access:	http://www.mdpi.com/2072-6651/5/9/1531

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