Bacillus cereus infection in pediatric oncology patients: A case report and review of literature
Introduction: Bacillus Cereus infection can be life-threatening in immunocompromised patients. We report here a case of Bacillus Cereus septicemia in a child with relapsed acute lymphoblastic leukemia (ALL) and present review of literature. Methods: We collected clinical, laboratory and outcome data...
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| Format: | Article |
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Elsevier
2021-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250921002584 |
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| author | Sunisha Arora Dhwanee Thakkar K. Upasana Anjali Yadav Neha Rastogi Satya Prakash Yadav |
| author_facet | Sunisha Arora Dhwanee Thakkar K. Upasana Anjali Yadav Neha Rastogi Satya Prakash Yadav |
| author_sort | Sunisha Arora |
| collection | DOAJ |
| description | Introduction: Bacillus Cereus infection can be life-threatening in immunocompromised patients. We report here a case of Bacillus Cereus septicemia in a child with relapsed acute lymphoblastic leukemia (ALL) and present review of literature. Methods: We collected clinical, laboratory and outcome data of our patient with relapsed ALL and Bacillus Cereus infection. We reviewed literature for Bacillus Cereus infection in pediatric oncology patients by searching MED-LINE/PubMed/Google/Google Scholar/Cochrane and summarized the data obtained. Various risk factors like presence of gastrointestinal or central nervous system (CNS) symptoms, neutropenia, central venous catheter in-situ, corticosteroids use, intrathecal chemotherapy and outcomes were analyzed using Fisher Exact Chi Square test. Results: A 15-years-old boy with relapsed ALL on induction chemotherapy presented with giddiness and difficulty in breathing. He had an episode of hematemesis followed by fainting at home. He had refractory shock which did not respond to fluid boluses, inotropes and hydrocortisone. He had severe metabolic acidosis with high lactate and ammonia and died within 36-hours of onset of symptoms. His blood culture was positive for Bacillus Cereus. We came across 36 published cases of Bacillus Cereus in children with cancer including present case. Of these, 28 had acute leukemia and rest 8 had other cancers. CNS symptoms were present in 13 patients. Overall mortality was 25%. Patients with multisystem involvement had significantly higher mortality compared to those having localized disease (p-value 0.033). Conclusion: In pediatric oncology patients on chemotherapy, cultures positive for Bacillus Cereus should be considered significant. Mortality is higher in those with multisystem involvement. |
| first_indexed | 2024-12-20T23:29:28Z |
| format | Article |
| id | doaj.art-54d600df03614a15ae757672a04c429f |
| institution | Directory Open Access Journal |
| issn | 2214-2509 |
| language | English |
| last_indexed | 2024-12-20T23:29:28Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj.art-54d600df03614a15ae757672a04c429f2022-12-21T19:23:18ZengElsevierIDCases2214-25092021-01-0126e01302Bacillus cereus infection in pediatric oncology patients: A case report and review of literatureSunisha Arora0Dhwanee Thakkar1K. Upasana2Anjali Yadav3Neha Rastogi4Satya Prakash Yadav5Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, IndiaPediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, IndiaPediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, IndiaPediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, IndiaPediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, IndiaCorrespondence to: Pediatric Hematology Oncology & BMT Unit, Cancer Institute, Medanta -The Medicity, Gurgaon, Haryana 122001, India.; Pediatric Hematology Oncology and Bone Marrow Transplant Unit, Cancer Institute, Medanta The Medicity Hospital, Gurgaon, Haryana, IndiaIntroduction: Bacillus Cereus infection can be life-threatening in immunocompromised patients. We report here a case of Bacillus Cereus septicemia in a child with relapsed acute lymphoblastic leukemia (ALL) and present review of literature. Methods: We collected clinical, laboratory and outcome data of our patient with relapsed ALL and Bacillus Cereus infection. We reviewed literature for Bacillus Cereus infection in pediatric oncology patients by searching MED-LINE/PubMed/Google/Google Scholar/Cochrane and summarized the data obtained. Various risk factors like presence of gastrointestinal or central nervous system (CNS) symptoms, neutropenia, central venous catheter in-situ, corticosteroids use, intrathecal chemotherapy and outcomes were analyzed using Fisher Exact Chi Square test. Results: A 15-years-old boy with relapsed ALL on induction chemotherapy presented with giddiness and difficulty in breathing. He had an episode of hematemesis followed by fainting at home. He had refractory shock which did not respond to fluid boluses, inotropes and hydrocortisone. He had severe metabolic acidosis with high lactate and ammonia and died within 36-hours of onset of symptoms. His blood culture was positive for Bacillus Cereus. We came across 36 published cases of Bacillus Cereus in children with cancer including present case. Of these, 28 had acute leukemia and rest 8 had other cancers. CNS symptoms were present in 13 patients. Overall mortality was 25%. Patients with multisystem involvement had significantly higher mortality compared to those having localized disease (p-value 0.033). Conclusion: In pediatric oncology patients on chemotherapy, cultures positive for Bacillus Cereus should be considered significant. Mortality is higher in those with multisystem involvement.http://www.sciencedirect.com/science/article/pii/S2214250921002584Bacillus CereusPediatric OncologyLeukemia |
| spellingShingle | Sunisha Arora Dhwanee Thakkar K. Upasana Anjali Yadav Neha Rastogi Satya Prakash Yadav Bacillus cereus infection in pediatric oncology patients: A case report and review of literature IDCases Bacillus Cereus Pediatric Oncology Leukemia |
| title | Bacillus cereus infection in pediatric oncology patients: A case report and review of literature |
| title_full | Bacillus cereus infection in pediatric oncology patients: A case report and review of literature |
| title_fullStr | Bacillus cereus infection in pediatric oncology patients: A case report and review of literature |
| title_full_unstemmed | Bacillus cereus infection in pediatric oncology patients: A case report and review of literature |
| title_short | Bacillus cereus infection in pediatric oncology patients: A case report and review of literature |
| title_sort | bacillus cereus infection in pediatric oncology patients a case report and review of literature |
| topic | Bacillus Cereus Pediatric Oncology Leukemia |
| url | http://www.sciencedirect.com/science/article/pii/S2214250921002584 |
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