Effect of Fluoxetine on Kidney of Albino Rats- A Histological Study
Introduction: Fluoxetine and other Selective Serotonin Reuptake Inhibitors (SSRIs) are reported to produce hyponatremia especially in elderly patients. Aim: To evaluate histological changes in kidney tissue of albino rats by different doses of fluoxetine for different duration and changes in the mea...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2019-10-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/13232/42396_CE[Ra1]_F(SHU)_PF1(TR_KM)_GC(AaG_SL)_PN(SL).pdf |
| Summary: | Introduction: Fluoxetine and other Selective Serotonin Reuptake Inhibitors (SSRIs) are reported to produce hyponatremia especially in elderly patients. Aim: To evaluate histological changes in kidney tissue of albino rats by different doses of fluoxetine for different duration and changes in the mean diameter of Proximal Convoluted Tubules (PCT) and Distal Convoluted Tubules (DCT) in control and experimental group was observed. Materials and Methods: An Experimental study was conducted in which total of 72 albino rats (36 male and 36 female) received single different doses- Mild (10 mg/Kg/day), moderate (20 mg/ kg/day) and high (40 mg/kg/day) of intraperitoneal injection of fluoxetine hydrochloride daily for 14 days (2 weeks), 28 days (4 weeks) and 84 days (12 weeks). Changes in kidney tissue histology were investigated and changes in the mean diameter of PCT and Distal convoluted tubules were also observed. Results: Mild and moderate doses of fluoxetine hydrochloride produce changes in the kidney histology in the form of appearance of podocytes bridge, degenerated/shrunken and swollen glomerulus, dilated tubules when given for long duration. High doses of fluoxetine change kidney histology within few days in the form of hypercellular shrunken glomerulus with apparently increased urinary/capsular space, appearance of podocytes bridge, dilated and degenerated tubules with presence of cast. Mean diameter of PCT was found to be increased in experimental rats in comparison to control rats (p<0.01) but there was no statistical significant change in diameter of DCT. Conclusion: The findings showed that fluoxetine produce changes in kidney histology both at the level of glomerulus and tubules. |
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| ISSN: | 2249-782X 0973-709X |