Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis
Aim. To examine the content of CD16, CD 25, CD95, and HLA-DR antigenic determinants in induced sputum (IS) of patients with bronchial asthma (BA) and chronic obstructive bronchitis (COB). Materials and methods. The study enrolled 36 patients with BA and 15 with COB whose age was 21 to 58 years. The...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2003-11-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/29709 |
| _version_ | 1811213613994606592 |
|---|---|
| author | V A Nevzorova Ye N Konovalova S A Pazych A V Kostyushko |
| author_facet | V A Nevzorova Ye N Konovalova S A Pazych A V Kostyushko |
| author_sort | V A Nevzorova |
| collection | DOAJ |
| description | Aim. To examine the content of CD16, CD 25, CD95, and HLA-DR antigenic determinants in induced sputum (IS) of patients with bronchial asthma (BA) and chronic obstructive bronchitis (COB).
Materials and methods. The study enrolled 36 patients with BA and 15 with COB whose age was 21
to 58 years. The cellular precipitate of IS served as a material for the study. The studied receptors
were determined by immunofluorescence using the "Clonospectrum " monoclonal antibodies.
Results. There was an increase in the content of CD16, CD25, HLA-DR, CD95 whose expression was
decreased when glucocorticosteroids were used. At remission of asthma, the level of these receptors approximated that in the control group. On an exacerbation of COB, the content of these markers was
significantly less than that in the controls and the use of antibacterial agents and methylxanthines led
to its rise. At remission of COB, CD 16 and CD25 cells were not recorded.
Conclusion. The levels of membrane markers in IM of patients with BA and COB depend on the period of the disease and used therapy. |
| first_indexed | 2024-04-12T05:49:36Z |
| format | Article |
| id | doaj.art-54d8c9e6327f4cf6bacfe6c2e9f6c881 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T05:49:36Z |
| publishDate | 2003-11-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-54d8c9e6327f4cf6bacfe6c2e9f6c8812022-12-22T03:45:20Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422003-11-017811616326737Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitisV A NevzorovaYe N KonovalovaS A PazychA V KostyushkoAim. To examine the content of CD16, CD 25, CD95, and HLA-DR antigenic determinants in induced sputum (IS) of patients with bronchial asthma (BA) and chronic obstructive bronchitis (COB). Materials and methods. The study enrolled 36 patients with BA and 15 with COB whose age was 21 to 58 years. The cellular precipitate of IS served as a material for the study. The studied receptors were determined by immunofluorescence using the "Clonospectrum " monoclonal antibodies. Results. There was an increase in the content of CD16, CD25, HLA-DR, CD95 whose expression was decreased when glucocorticosteroids were used. At remission of asthma, the level of these receptors approximated that in the control group. On an exacerbation of COB, the content of these markers was significantly less than that in the controls and the use of antibacterial agents and methylxanthines led to its rise. At remission of COB, CD 16 and CD25 cells were not recorded. Conclusion. The levels of membrane markers in IM of patients with BA and COB depend on the period of the disease and used therapy.https://ter-arkhiv.ru/0040-3660/article/view/29709bronchial asthmachronic bronchitismembrane markers |
| spellingShingle | V A Nevzorova Ye N Konovalova S A Pazych A V Kostyushko Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis Терапевтический архив bronchial asthma chronic bronchitis membrane markers |
| title | Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis |
| title_full | Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis |
| title_fullStr | Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis |
| title_full_unstemmed | Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis |
| title_short | Content of the antigenic determinants CD16, CD 25,CD95, and HLA-DR in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis |
| title_sort | content of the antigenic determinants cd16 cd 25 cd95 and hla dr in the induced sputum of patientswith bronchial asthma and chronic obstructive bronchitis |
| topic | bronchial asthma chronic bronchitis membrane markers |
| url | https://ter-arkhiv.ru/0040-3660/article/view/29709 |
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