Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi
This article explores the diverse array of biologically active compounds derived from microbial symbionts, particularly focusing on the isolation and characterization of diepoxides, highly oxygenated triterpenoids, secosteroids, ergostane-type steroids, and meroterpenoids from various marine and pla...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Microbiology Research |
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| Online Access: | https://www.mdpi.com/2036-7481/15/1/5 |
| _version_ | 1797239994695286784 |
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| author | Valery M. Dembitsky |
| author_facet | Valery M. Dembitsky |
| author_sort | Valery M. Dembitsky |
| collection | DOAJ |
| description | This article explores the diverse array of biologically active compounds derived from microbial symbionts, particularly focusing on the isolation and characterization of diepoxides, highly oxygenated triterpenoids, secosteroids, ergostane-type steroids, and meroterpenoids from various marine and plant-derived fungi. We highlight significant discoveries such as vitamin D variants from fungal species, unique sesterterpenoids from mangrove endophytic fungi, and secosteroids with potential medicinal applications. The study delves into the structural uniqueness and bioactivities of these compounds, including their anti-inflammatory, antibacterial, antifungal, antiviral, and cytotoxic effects. Notable findings include the isolation of compounds with significant activity against cancer cell lines, the inhibition of acetylcholinesterase, and promising antifouling properties. This work underscores the potential of microbial symbionts as a rich source of novel bioactive compounds with diverse therapeutic applications, highlighting the importance of marine and fungal biodiversity in drug discovery and development. |
| first_indexed | 2024-04-24T18:00:23Z |
| format | Article |
| id | doaj.art-54daaa886c604591b1712d5d19c27d9e |
| institution | Directory Open Access Journal |
| issn | 2036-7481 |
| language | English |
| last_indexed | 2024-04-24T18:00:23Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microbiology Research |
| spelling | doaj.art-54daaa886c604591b1712d5d19c27d9e2024-03-27T13:54:48ZengMDPI AGMicrobiology Research2036-74812023-12-01151669010.3390/microbiolres15010005Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and FungiValery M. Dembitsky0Centre for Applied Research, Innovation and Entrepreneurship, Lethbridge College, 3000 College Drive South, Lethbridge, AB T1K 1L6, CanadaThis article explores the diverse array of biologically active compounds derived from microbial symbionts, particularly focusing on the isolation and characterization of diepoxides, highly oxygenated triterpenoids, secosteroids, ergostane-type steroids, and meroterpenoids from various marine and plant-derived fungi. We highlight significant discoveries such as vitamin D variants from fungal species, unique sesterterpenoids from mangrove endophytic fungi, and secosteroids with potential medicinal applications. The study delves into the structural uniqueness and bioactivities of these compounds, including their anti-inflammatory, antibacterial, antifungal, antiviral, and cytotoxic effects. Notable findings include the isolation of compounds with significant activity against cancer cell lines, the inhibition of acetylcholinesterase, and promising antifouling properties. This work underscores the potential of microbial symbionts as a rich source of novel bioactive compounds with diverse therapeutic applications, highlighting the importance of marine and fungal biodiversity in drug discovery and development.https://www.mdpi.com/2036-7481/15/1/5microbial symbiontsbacteriafungal endophytesfungidiepoxidesoxygenated triterpenoids |
| spellingShingle | Valery M. Dembitsky Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi Microbiology Research microbial symbionts bacteria fungal endophytes fungi diepoxides oxygenated triterpenoids |
| title | Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi |
| title_full | Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi |
| title_fullStr | Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi |
| title_full_unstemmed | Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi |
| title_short | Bioactive Diepoxy Metabolites and Highly Oxygenated Triterpenoids from Marine and Plant-Derived Bacteria and Fungi |
| title_sort | bioactive diepoxy metabolites and highly oxygenated triterpenoids from marine and plant derived bacteria and fungi |
| topic | microbial symbionts bacteria fungal endophytes fungi diepoxides oxygenated triterpenoids |
| url | https://www.mdpi.com/2036-7481/15/1/5 |
| work_keys_str_mv | AT valerymdembitsky bioactivediepoxymetabolitesandhighlyoxygenatedtriterpenoidsfrommarineandplantderivedbacteriaandfungi |