HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection.
BACKGROUND: Hepatitis C virus (HCV) emerged as sexually transmitted infection among HIV-infected men who have sex with men (MSM). We studied whether HCV circulated in identifiable high-risk MSM subcultures and performed phylogenetic analysis. METHODS: HIV-infected MSM were recruited at the sexually...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3587624?pdf=render |
| _version_ | 1818309018574127104 |
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| author | Amy Matser Joost Vanhommerig Maarten F Schim van der Loeff Ronald B Geskus Henry J C de Vries Jan M Prins Maria Prins Sylvia M Bruisten |
| author_facet | Amy Matser Joost Vanhommerig Maarten F Schim van der Loeff Ronald B Geskus Henry J C de Vries Jan M Prins Maria Prins Sylvia M Bruisten |
| author_sort | Amy Matser |
| collection | DOAJ |
| description | BACKGROUND: Hepatitis C virus (HCV) emerged as sexually transmitted infection among HIV-infected men who have sex with men (MSM). We studied whether HCV circulated in identifiable high-risk MSM subcultures and performed phylogenetic analysis. METHODS: HIV-infected MSM were recruited at the sexually transmitted infections (STI) outpatient clinic and a university HIV clinic in Amsterdam, the Netherlands, 2008-2009. Participants completed a detailed questionnaire and were tested for HCV antibodies and RNA, with NS5B regions sequenced for analysis of clusters. RESULTS: Among 786 participants, the median age was 43 (IQR 37-48) years, and 93 (11.8%) were HCV-positive. Seropositivity was associated with belonging to subcultures identified as leather (aOR 2.60; 95% CI 1.56-4.33), rubber/lycra (aOR 2.15; 95% CI 1.10-4.21), or jeans (aOR 2.23; 95% CI 1.41-3.54). The two largest HCV-RNA monophyletic clusters were compared; MSM in cluster I (genotype 1a, n = 13) reported more partners (P = 0.037) than MSM in cluster II (genotype 4d, n = 14), but demographics, subculture characteristics and other risk behaviors did not differ significantly between the two clusters. DISCUSSION: HCV infection is associated with identifiable groups of leather/rubber/lycra/jeans subcultures among HIV-infected MSM. Separate epidemiological HCV transmission networks were not revealed. Active HCV screening and treatment within specific subcultures may reduce HCV spread among all MSM. |
| first_indexed | 2024-12-13T07:23:30Z |
| format | Article |
| id | doaj.art-54dede54947145cca20e0ce1e32f329e |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T07:23:30Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-54dede54947145cca20e0ce1e32f329e2022-12-21T23:55:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0183e5774010.1371/journal.pone.0057740HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection.Amy MatserJoost VanhommerigMaarten F Schim van der LoeffRonald B GeskusHenry J C de VriesJan M PrinsMaria PrinsSylvia M BruistenBACKGROUND: Hepatitis C virus (HCV) emerged as sexually transmitted infection among HIV-infected men who have sex with men (MSM). We studied whether HCV circulated in identifiable high-risk MSM subcultures and performed phylogenetic analysis. METHODS: HIV-infected MSM were recruited at the sexually transmitted infections (STI) outpatient clinic and a university HIV clinic in Amsterdam, the Netherlands, 2008-2009. Participants completed a detailed questionnaire and were tested for HCV antibodies and RNA, with NS5B regions sequenced for analysis of clusters. RESULTS: Among 786 participants, the median age was 43 (IQR 37-48) years, and 93 (11.8%) were HCV-positive. Seropositivity was associated with belonging to subcultures identified as leather (aOR 2.60; 95% CI 1.56-4.33), rubber/lycra (aOR 2.15; 95% CI 1.10-4.21), or jeans (aOR 2.23; 95% CI 1.41-3.54). The two largest HCV-RNA monophyletic clusters were compared; MSM in cluster I (genotype 1a, n = 13) reported more partners (P = 0.037) than MSM in cluster II (genotype 4d, n = 14), but demographics, subculture characteristics and other risk behaviors did not differ significantly between the two clusters. DISCUSSION: HCV infection is associated with identifiable groups of leather/rubber/lycra/jeans subcultures among HIV-infected MSM. Separate epidemiological HCV transmission networks were not revealed. Active HCV screening and treatment within specific subcultures may reduce HCV spread among all MSM.http://europepmc.org/articles/PMC3587624?pdf=render |
| spellingShingle | Amy Matser Joost Vanhommerig Maarten F Schim van der Loeff Ronald B Geskus Henry J C de Vries Jan M Prins Maria Prins Sylvia M Bruisten HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection. PLoS ONE |
| title | HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection. |
| title_full | HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection. |
| title_fullStr | HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection. |
| title_full_unstemmed | HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection. |
| title_short | HIV-infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis C infection. |
| title_sort | hiv infected men who have sex with men who identify themselves as belonging to subcultures are at increased risk for hepatitis c infection |
| url | http://europepmc.org/articles/PMC3587624?pdf=render |
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