Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation
Aim: The underlying mechanisms of cluster headache (CH) have not been fully understood yet. The cranial autonomic activation suggests that both sympathetic and parasympathetic systems are impaired in the clinical presentation; however, the systemic autonomic involvement during pain-free episodes is...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neurological Sciences and Neurophysiology |
| Subjects: | |
| Online Access: | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=3;spage=146;epage=150;aulast=Sahin |
| _version_ | 1811240655583707136 |
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| author | Erdi Sahin Esme Ekizoglu Elif Kocasoy Orhan Ahmet Kaya Bilge Betul Baykan |
| author_facet | Erdi Sahin Esme Ekizoglu Elif Kocasoy Orhan Ahmet Kaya Bilge Betul Baykan |
| author_sort | Erdi Sahin |
| collection | DOAJ |
| description | Aim: The underlying mechanisms of cluster headache (CH) have not been fully understood yet. The cranial autonomic activation suggests that both sympathetic and parasympathetic systems are impaired in the clinical presentation; however, the systemic autonomic involvement during pain-free episodes is not well-known. Methods: Thirty-five subjects were included in 24 h Holter monitoring and electrophysiological studies in this controlled study. Results: In Holter monitoring, heart rate variability parameters, RMSSD (P = 0.001), and pNN50 (P = 0.024) were significantly higher in patients compared to age and gender-matched controls. The R-R variations during breathing and deep breathing and sympathetic skin responses of all patients were normal. Conclusions: High RMSSD and pNN50 levels are the two indicators of increased parasympathetic activity in CH patients. Considering the intense stress because of severe pain of the CH patients, who are mostly adult men and smokers, there is an urgent need for broader studies with prospective follow-up in terms of cardiac health. |
| first_indexed | 2024-04-12T13:24:03Z |
| format | Article |
| id | doaj.art-54e18ec083b843e4b4618053083e584c |
| institution | Directory Open Access Journal |
| issn | 2636-865X |
| language | English |
| last_indexed | 2024-04-12T13:24:03Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neurological Sciences and Neurophysiology |
| spelling | doaj.art-54e18ec083b843e4b4618053083e584c2022-12-22T03:31:23ZengWolters Kluwer Medknow PublicationsNeurological Sciences and Neurophysiology2636-865X2022-01-0139314615010.4103/nsn.nsn_154_21Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activationErdi SahinEsme EkizogluElif Kocasoy OrhanAhmet Kaya BilgeBetul BaykanAim: The underlying mechanisms of cluster headache (CH) have not been fully understood yet. The cranial autonomic activation suggests that both sympathetic and parasympathetic systems are impaired in the clinical presentation; however, the systemic autonomic involvement during pain-free episodes is not well-known. Methods: Thirty-five subjects were included in 24 h Holter monitoring and electrophysiological studies in this controlled study. Results: In Holter monitoring, heart rate variability parameters, RMSSD (P = 0.001), and pNN50 (P = 0.024) were significantly higher in patients compared to age and gender-matched controls. The R-R variations during breathing and deep breathing and sympathetic skin responses of all patients were normal. Conclusions: High RMSSD and pNN50 levels are the two indicators of increased parasympathetic activity in CH patients. Considering the intense stress because of severe pain of the CH patients, who are mostly adult men and smokers, there is an urgent need for broader studies with prospective follow-up in terms of cardiac health.http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=3;spage=146;epage=150;aulast=Sahinautonomicclusterheadachepathophysiology |
| spellingShingle | Erdi Sahin Esme Ekizoglu Elif Kocasoy Orhan Ahmet Kaya Bilge Betul Baykan Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation Neurological Sciences and Neurophysiology autonomic cluster headache pathophysiology |
| title | Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation |
| title_full | Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation |
| title_fullStr | Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation |
| title_full_unstemmed | Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation |
| title_short | Understanding pathophysiology of cluster headache: Heart rate variability and parasympathetic activation |
| title_sort | understanding pathophysiology of cluster headache heart rate variability and parasympathetic activation |
| topic | autonomic cluster headache pathophysiology |
| url | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=3;spage=146;epage=150;aulast=Sahin |
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