Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats

Conditional Oprk1-dependent Kiss1 deletion in kisspeptin neurons caused estrogen-dependent LH pulse disruption and LH surge attenuation in female rats

Abstract The gonadotropin-releasing hormone (GnRH) pulse and surge are considered to be generated by arcuate kisspeptin/neurokinin B/dynorphin A (KNDy) neurons and anteroventral periventricular nucleus (AVPV) kisspeptin neurons, respectively, in female rodents. The majority of KNDy and AVPV kisspept...

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Bibliographic Details
Main Authors: Mayuko Nagae, Koki Yamada, Yuki Enomoto, Mari Kometani, Hitomi Tsuchida, Arvinda Panthee, Miku Nonogaki, Nao Matsunaga, Marina Takizawa, Sena Matsuzaki, Masumi Hirabayashi, Naoko Inoue, Hiroko Tsukamura, Yoshihisa Uenoyama
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-47222-5

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