Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats
Anemia is a grave public health issue that affects 25% of the global population. Conventional iron formulations used in treatment have drawbacks such as poor bioavailability and gastric intolerability. The current study aimed to evaluate the anti-anemic effects of different iron salts in Wistar rats...
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| Format: | Article |
| Language: | English |
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Sciendo
2024-03-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
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| Online Access: | https://doi.org/10.2478/cipms-2024-0005 |
| _version_ | 1797208428341362688 |
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| author | Suva Manoj Arajanbhai Tirgar Pravin Rambhai |
| author_facet | Suva Manoj Arajanbhai Tirgar Pravin Rambhai |
| author_sort | Suva Manoj Arajanbhai |
| collection | DOAJ |
| description | Anemia is a grave public health issue that affects 25% of the global population. Conventional iron formulations used in treatment have drawbacks such as poor bioavailability and gastric intolerability. The current study aimed to evaluate the anti-anemic effects of different iron salts in Wistar rats with iron deficiency anemia (IDA). IDA was induced by the validated pre-clinical model by retro-orbital bloodletting (1 ml) for 21 days along with an iron-deficient diet in Wistar rats. The rats (n=48) were assigned into 8 groups: Control group, IDA rats, IDA rats receiving either vehicle or different iron salts (ferrous sulfate, ferrous ascorbate, ferrous fumarate, and Sucrosomial iron) for 21 days at a dose of 30 mg/kg p.o. Hematological parameters and iron store indices were assessed at each visit. |
| first_indexed | 2024-04-24T09:38:39Z |
| format | Article |
| id | doaj.art-54e6274406a14037968c9d7de55aa4d2 |
| institution | Directory Open Access Journal |
| issn | 2300-6676 |
| language | English |
| last_indexed | 2024-04-24T09:38:39Z |
| publishDate | 2024-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-54e6274406a14037968c9d7de55aa4d22024-04-15T07:42:46ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2300-66762024-03-01371263210.2478/cipms-2024-0005Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar ratsSuva Manoj Arajanbhai0Tirgar Pravin Rambhai1Department of Pharmacology, RK University, School of Pharmacy, Gujarat, IndiaDepartment of Pharmacology, RK University, School of Pharmacy, Gujarat, IndiaAnemia is a grave public health issue that affects 25% of the global population. Conventional iron formulations used in treatment have drawbacks such as poor bioavailability and gastric intolerability. The current study aimed to evaluate the anti-anemic effects of different iron salts in Wistar rats with iron deficiency anemia (IDA). IDA was induced by the validated pre-clinical model by retro-orbital bloodletting (1 ml) for 21 days along with an iron-deficient diet in Wistar rats. The rats (n=48) were assigned into 8 groups: Control group, IDA rats, IDA rats receiving either vehicle or different iron salts (ferrous sulfate, ferrous ascorbate, ferrous fumarate, and Sucrosomial iron) for 21 days at a dose of 30 mg/kg p.o. Hematological parameters and iron store indices were assessed at each visit.https://doi.org/10.2478/cipms-2024-0005iron deficiency anemiabloodlettingconventional oral ironsucrosomial ironiron store indices. |
| spellingShingle | Suva Manoj Arajanbhai Tirgar Pravin Rambhai Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats Current Issues in Pharmacy and Medical Sciences iron deficiency anemia bloodletting conventional oral iron sucrosomial iron iron store indices. |
| title | Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats |
| title_full | Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats |
| title_fullStr | Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats |
| title_full_unstemmed | Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats |
| title_short | Comparative evaluation of anti-anemic effect of Sucrosomial iron in experimental model of iron deficiency anemia in Wistar rats |
| title_sort | comparative evaluation of anti anemic effect of sucrosomial iron in experimental model of iron deficiency anemia in wistar rats |
| topic | iron deficiency anemia bloodletting conventional oral iron sucrosomial iron iron store indices. |
| url | https://doi.org/10.2478/cipms-2024-0005 |
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