Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China
AimsNeonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows.Metho...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1052836/full |
| _version_ | 1811213769158688768 |
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| author | Qingzhi Hou Qingzhi Hou Hui Zou Shuping Zhang Shuping Zhang Shuping Zhang Shuping Zhang Jiujing Lin Jiujing Lin Wenying Nie Yazhou Cui Yazhou Cui Yazhou Cui Sijin Liu Sijin Liu Jinxiang Han Jinxiang Han Jinxiang Han |
| author_facet | Qingzhi Hou Qingzhi Hou Hui Zou Shuping Zhang Shuping Zhang Shuping Zhang Shuping Zhang Jiujing Lin Jiujing Lin Wenying Nie Yazhou Cui Yazhou Cui Yazhou Cui Sijin Liu Sijin Liu Jinxiang Han Jinxiang Han Jinxiang Han |
| author_sort | Qingzhi Hou |
| collection | DOAJ |
| description | AimsNeonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows.MethodsPregnant women were recruited in Jinan Maternity and Child Care Hospital and followed up until delivery. Multivariate generalized linear regression models (GLMs) and restricted cubic spline (RCS) regression analysis models were used to investigate the associations of maternal TSH and FT4 with neonatal metabolites.ResultsIn total, 6,653 pairs of mothers and newborns were enrolled in our study. We identified 5 neonatal metabolites, including arginine/ornithine (Arg/Orn), C14:1/C2, C18:1, C3DC+C4OH and C8:1, that were significantly associated with maternal serum TSH during the whole pregnancy (P < 0.05), especially in the first trimester. Moreover, 10 neonatal metabolites were significantly associated with maternal serum FT4 (P < 0.05), most of which had positive correlations with maternal FT4 in the first trimester (P < 0.05). Some neonatal metabolites also had linear or nonlinear dose-effect relationships with maternal serum TSH and FT4 during the whole pregnancy, particularly in the first trimester.ConclusionsOur study, for the first time, provides epidemiological evidence that maternal serum TSH and FT4, especially during the first trimester, are associated with linear or nonlinear variations in neonatal metabolites. Efforts to identify newborn metabolism levels should carefully consider the effects of maternal thyroid function. |
| first_indexed | 2024-04-12T05:51:45Z |
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| id | doaj.art-54e6b6888e6f4e25a918819df9c82bb9 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T05:51:45Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-54e6b6888e6f4e25a918819df9c82bb92022-12-22T03:45:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-12-011310.3389/fendo.2022.10528361052836Association of maternal TSH and neonatal metabolism: A large prospective cohort study in ChinaQingzhi Hou0Qingzhi Hou1Hui Zou2Shuping Zhang3Shuping Zhang4Shuping Zhang5Shuping Zhang6Jiujing Lin7Jiujing Lin8Wenying Nie9Yazhou Cui10Yazhou Cui11Yazhou Cui12Sijin Liu13Sijin Liu14Jinxiang Han15Jinxiang Han16Jinxiang Han17Medical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaJinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaBiomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaNHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaKey Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaJinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaBiomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaNHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaKey Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaMedical Science and Technology Innovation Center, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaState Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, ChinaBiomedical Sciences College & Shandong Medicinal Biotechnology Centre, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaNHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences), Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaKey Lab for Rare & Uncommon Diseases of Shandong Province, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, ChinaAimsNeonatal metabolites are very important in neonatal disease screening, and maternal thyroid hormones play an important role in fetal and neonatal health. Our study aimed to explore the association of maternal thyroid hormones with neonatal metabolites and identify an important time windows.MethodsPregnant women were recruited in Jinan Maternity and Child Care Hospital and followed up until delivery. Multivariate generalized linear regression models (GLMs) and restricted cubic spline (RCS) regression analysis models were used to investigate the associations of maternal TSH and FT4 with neonatal metabolites.ResultsIn total, 6,653 pairs of mothers and newborns were enrolled in our study. We identified 5 neonatal metabolites, including arginine/ornithine (Arg/Orn), C14:1/C2, C18:1, C3DC+C4OH and C8:1, that were significantly associated with maternal serum TSH during the whole pregnancy (P < 0.05), especially in the first trimester. Moreover, 10 neonatal metabolites were significantly associated with maternal serum FT4 (P < 0.05), most of which had positive correlations with maternal FT4 in the first trimester (P < 0.05). Some neonatal metabolites also had linear or nonlinear dose-effect relationships with maternal serum TSH and FT4 during the whole pregnancy, particularly in the first trimester.ConclusionsOur study, for the first time, provides epidemiological evidence that maternal serum TSH and FT4, especially during the first trimester, are associated with linear or nonlinear variations in neonatal metabolites. Efforts to identify newborn metabolism levels should carefully consider the effects of maternal thyroid function.https://www.frontiersin.org/articles/10.3389/fendo.2022.1052836/fullpregnancymaternal TSHneonatal metabolitesdose-effect relationshipmaternal FT4 |
| spellingShingle | Qingzhi Hou Qingzhi Hou Hui Zou Shuping Zhang Shuping Zhang Shuping Zhang Shuping Zhang Jiujing Lin Jiujing Lin Wenying Nie Yazhou Cui Yazhou Cui Yazhou Cui Sijin Liu Sijin Liu Jinxiang Han Jinxiang Han Jinxiang Han Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China Frontiers in Endocrinology pregnancy maternal TSH neonatal metabolites dose-effect relationship maternal FT4 |
| title | Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China |
| title_full | Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China |
| title_fullStr | Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China |
| title_full_unstemmed | Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China |
| title_short | Association of maternal TSH and neonatal metabolism: A large prospective cohort study in China |
| title_sort | association of maternal tsh and neonatal metabolism a large prospective cohort study in china |
| topic | pregnancy maternal TSH neonatal metabolites dose-effect relationship maternal FT4 |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1052836/full |
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