Liver in infections: a single-cell and spatial transcriptomics perspective
Abstract The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human body. During acute and chronic infections, the liver transforms from a tolerant to an active immune state. The defence mechanism of the liver...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-07-01
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| Series: | Journal of Biomedical Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12929-023-00945-z |
| _version_ | 1797778760043331584 |
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| author | Ju Zou Jie Li Xiao Zhong Daolin Tang Xuegong Fan Ruochan Chen |
| author_facet | Ju Zou Jie Li Xiao Zhong Daolin Tang Xuegong Fan Ruochan Chen |
| author_sort | Ju Zou |
| collection | DOAJ |
| description | Abstract The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human body. During acute and chronic infections, the liver transforms from a tolerant to an active immune state. The defence mechanism of the liver mainly depends on a complicated network of intrahepatic and translocated immune cells and non-immune cells. Therefore, a comprehensive liver cell atlas in both healthy and diseased states is needed for new therapeutic target development and disease intervention improvement. With the development of high-throughput single-cell technology, we can now decipher heterogeneity, differentiation, and intercellular communication at the single-cell level in sophisticated organs and complicated diseases. In this concise review, we aimed to summarise the advancement of emerging high-throughput single-cell technologies and re-define our understanding of liver function towards infections, including hepatitis B virus, hepatitis C virus, Plasmodium, schistosomiasis, endotoxemia, and corona virus disease 2019 (COVID-19). We also unravel previously unknown pathogenic pathways and disease mechanisms for the development of new therapeutic targets. As high-throughput single-cell technologies mature, their integration into spatial transcriptomics, multiomics, and clinical data analysis will aid in patient stratification and in developing effective treatment plans for patients with or without liver injury due to infectious diseases. |
| first_indexed | 2024-03-12T23:21:11Z |
| format | Article |
| id | doaj.art-54e8a0b0fe5347348410355ac44c3377 |
| institution | Directory Open Access Journal |
| issn | 1423-0127 |
| language | English |
| last_indexed | 2024-03-12T23:21:11Z |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Biomedical Science |
| spelling | doaj.art-54e8a0b0fe5347348410355ac44c33772023-07-16T11:23:56ZengBMCJournal of Biomedical Science1423-01272023-07-0130112510.1186/s12929-023-00945-zLiver in infections: a single-cell and spatial transcriptomics perspectiveJu Zou0Jie Li1Xiao Zhong2Daolin Tang3Xuegong Fan4Ruochan Chen5Hunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South UniversityHunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South UniversityHunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South UniversityDepartment of Surgery, UT Southwestern Medical CenterHunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South UniversityHunan Key Laboratory of Viral Hepatitis, Xiangya Hospital, Central South UniversityAbstract The liver is an immune organ that plays a vital role in the detection, capture, and clearance of pathogens and foreign antigens that invade the human body. During acute and chronic infections, the liver transforms from a tolerant to an active immune state. The defence mechanism of the liver mainly depends on a complicated network of intrahepatic and translocated immune cells and non-immune cells. Therefore, a comprehensive liver cell atlas in both healthy and diseased states is needed for new therapeutic target development and disease intervention improvement. With the development of high-throughput single-cell technology, we can now decipher heterogeneity, differentiation, and intercellular communication at the single-cell level in sophisticated organs and complicated diseases. In this concise review, we aimed to summarise the advancement of emerging high-throughput single-cell technologies and re-define our understanding of liver function towards infections, including hepatitis B virus, hepatitis C virus, Plasmodium, schistosomiasis, endotoxemia, and corona virus disease 2019 (COVID-19). We also unravel previously unknown pathogenic pathways and disease mechanisms for the development of new therapeutic targets. As high-throughput single-cell technologies mature, their integration into spatial transcriptomics, multiomics, and clinical data analysis will aid in patient stratification and in developing effective treatment plans for patients with or without liver injury due to infectious diseases.https://doi.org/10.1186/s12929-023-00945-zLiverInfectionsSingle-cell technologiesSpatial transcriptome |
| spellingShingle | Ju Zou Jie Li Xiao Zhong Daolin Tang Xuegong Fan Ruochan Chen Liver in infections: a single-cell and spatial transcriptomics perspective Journal of Biomedical Science Liver Infections Single-cell technologies Spatial transcriptome |
| title | Liver in infections: a single-cell and spatial transcriptomics perspective |
| title_full | Liver in infections: a single-cell and spatial transcriptomics perspective |
| title_fullStr | Liver in infections: a single-cell and spatial transcriptomics perspective |
| title_full_unstemmed | Liver in infections: a single-cell and spatial transcriptomics perspective |
| title_short | Liver in infections: a single-cell and spatial transcriptomics perspective |
| title_sort | liver in infections a single cell and spatial transcriptomics perspective |
| topic | Liver Infections Single-cell technologies Spatial transcriptome |
| url | https://doi.org/10.1186/s12929-023-00945-z |
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