Association of Helicobacter pylori infection with gastroesophageal reflux disease
Introduction: The study was conducted to determine the association of Helicobactor pylori with endoscopic and histological parameters of gastroesophageal reflux disease (GERD). Materials and Methods: A cross-sectional study was undertaken. A total of 79 patients were evaluated prospectively in the e...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Archives of Medicine and Health Sciences |
| Subjects: | |
| Online Access: | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2016;volume=4;issue=1;spage=22;epage=25;aulast=Chandramohan |
| _version_ | 1818893114184564736 |
|---|---|
| author | Aswathy Chandramohan A V Ramadevi K T Shenoy Sheela Vasudevan |
| author_facet | Aswathy Chandramohan A V Ramadevi K T Shenoy Sheela Vasudevan |
| author_sort | Aswathy Chandramohan |
| collection | DOAJ |
| description | Introduction: The study was conducted to determine the association of Helicobactor pylori with endoscopic and histological parameters of gastroesophageal reflux disease (GERD). Materials and Methods: A cross-sectional study was undertaken. A total of 79 patients were evaluated prospectively in the endoscopic unit of a gastroenterology department for symptoms compatible with GERD. In all cases, routine endoscopy and Los Angeles grading of GERD were performed. In each subject, biopsies were taken from 3 cm above the squamocolumnar junction and from the antrum and assessed histologically. Results: Majority of the patients presented with complaints of heartburn (84.8%) and regurgitation (75.9%). Nonerosive reflux disease was present in only five patients. Endoscopically, the remaining 74 cases were graded as follows: 25 had GERD A, 10 had GERD B, 35 had features of Barrett's esophagus, and 4 had miscellaneous findings. H. pylori positivity was present in 33.3% of patients with GERD A and 4.8% of those with GERD B. Majority of the histological parameters such as elongation of lamina propria papillae, intraepithelial inflammatory infiltrate, ballooning degeneration, lack of surface maturation, and dilatation and congestion of lamina propria capillaries did not show statistically significant association with H. pylori. The overall H. pylori prevalence was found to be 26.58% (21/79). Conclusion: On endoscopy, with the increased GERD severity, H. pylori incidence decreased. H. pylori was found to have no significant association with majority of the histological parameters. |
| first_indexed | 2024-12-19T18:07:27Z |
| format | Article |
| id | doaj.art-54e9beeb846f41449bb45e3b14278630 |
| institution | Directory Open Access Journal |
| issn | 2321-4848 |
| language | English |
| last_indexed | 2024-12-19T18:07:27Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Archives of Medicine and Health Sciences |
| spelling | doaj.art-54e9beeb846f41449bb45e3b142786302022-12-21T20:11:24ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482016-01-0141222510.4103/2321-4848.183368Association of Helicobacter pylori infection with gastroesophageal reflux diseaseAswathy ChandramohanA V RamadeviK T ShenoySheela VasudevanIntroduction: The study was conducted to determine the association of Helicobactor pylori with endoscopic and histological parameters of gastroesophageal reflux disease (GERD). Materials and Methods: A cross-sectional study was undertaken. A total of 79 patients were evaluated prospectively in the endoscopic unit of a gastroenterology department for symptoms compatible with GERD. In all cases, routine endoscopy and Los Angeles grading of GERD were performed. In each subject, biopsies were taken from 3 cm above the squamocolumnar junction and from the antrum and assessed histologically. Results: Majority of the patients presented with complaints of heartburn (84.8%) and regurgitation (75.9%). Nonerosive reflux disease was present in only five patients. Endoscopically, the remaining 74 cases were graded as follows: 25 had GERD A, 10 had GERD B, 35 had features of Barrett's esophagus, and 4 had miscellaneous findings. H. pylori positivity was present in 33.3% of patients with GERD A and 4.8% of those with GERD B. Majority of the histological parameters such as elongation of lamina propria papillae, intraepithelial inflammatory infiltrate, ballooning degeneration, lack of surface maturation, and dilatation and congestion of lamina propria capillaries did not show statistically significant association with H. pylori. The overall H. pylori prevalence was found to be 26.58% (21/79). Conclusion: On endoscopy, with the increased GERD severity, H. pylori incidence decreased. H. pylori was found to have no significant association with majority of the histological parameters.http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2016;volume=4;issue=1;spage=22;epage=25;aulast=ChandramohanEndoscopygastroesophageal reflux diseaseHelicobacter pylorihistologyspecial stain |
| spellingShingle | Aswathy Chandramohan A V Ramadevi K T Shenoy Sheela Vasudevan Association of Helicobacter pylori infection with gastroesophageal reflux disease Archives of Medicine and Health Sciences Endoscopy gastroesophageal reflux disease Helicobacter pylori histology special stain |
| title | Association of Helicobacter pylori infection with gastroesophageal reflux disease |
| title_full | Association of Helicobacter pylori infection with gastroesophageal reflux disease |
| title_fullStr | Association of Helicobacter pylori infection with gastroesophageal reflux disease |
| title_full_unstemmed | Association of Helicobacter pylori infection with gastroesophageal reflux disease |
| title_short | Association of Helicobacter pylori infection with gastroesophageal reflux disease |
| title_sort | association of helicobacter pylori infection with gastroesophageal reflux disease |
| topic | Endoscopy gastroesophageal reflux disease Helicobacter pylori histology special stain |
| url | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2016;volume=4;issue=1;spage=22;epage=25;aulast=Chandramohan |
| work_keys_str_mv | AT aswathychandramohan associationofhelicobacterpyloriinfectionwithgastroesophagealrefluxdisease AT avramadevi associationofhelicobacterpyloriinfectionwithgastroesophagealrefluxdisease AT ktshenoy associationofhelicobacterpyloriinfectionwithgastroesophagealrefluxdisease AT sheelavasudevan associationofhelicobacterpyloriinfectionwithgastroesophagealrefluxdisease |