Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial
The presence of malnutrition is increasingly becoming a postdischarge problem in surgical patients. We aimed to investigate whether oral nutritional supplements combined with resistance training could minimize skeletal muscle atrophy in surgical patients after discharge. This randomized controlled s...
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MDPI AG
2022-06-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/13/2599 |
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| author | Poula Patursson Grith Møller Bjartur Bernhardson Thomsen Eyðfinnur Olsen Jann Mortensen Guðrið Andorsdóttir Magni Mohr Jens Rikardt Andersen |
| author_facet | Poula Patursson Grith Møller Bjartur Bernhardson Thomsen Eyðfinnur Olsen Jann Mortensen Guðrið Andorsdóttir Magni Mohr Jens Rikardt Andersen |
| author_sort | Poula Patursson |
| collection | DOAJ |
| description | The presence of malnutrition is increasingly becoming a postdischarge problem in surgical patients. We aimed to investigate whether oral nutritional supplements combined with resistance training could minimize skeletal muscle atrophy in surgical patients after discharge. This randomized controlled study was conducted at the Department of Surgery, National Hospital of Faroe Islands from 2018 to 2020. A total of 45 patients aged 37–74 years participated and were allocated to one of three groups: diet (DI; <i>n</i> = 13), exercise and diet (EX + DI; <i>n</i> = 16), or control (CON; <i>n</i> = 16). The intervention period lasted 8 weeks. The intervention groups received individual dietary counselling and a protein-rich oral nutritional supplement twice a day containing 22 g of protein/day. Patients in the EX + DI group were assigned to resistance training sessions. Patients in the CON group received standard care. The primary outcome was change in lean body mass (LBM). Secondary outcomes were change in body weight, handgrip strength, quality of life, surgery-related side effects, energy and protein intake, length of stay and one-year mortality. To estimate within-group changes, linear mixed models including group–time interactions as fixed effects and patients as random effects were fitted. Within-group change in LBM was 233, 813 and 78 g in the DI, EX + DI and CON groups, respectively, with no significant between-group difference (<i>p</i> > 0.05). Pain score declined more (<i>p</i> = 0.04) in the EX + DI group compared with the CON group. Body weight, handgrip strength, quality of life and surgery-related side effects did not differ between groups. At the end of study, mean cumulative weight change in the DI and EX + DI groups was 0.4% and 1.6%, respectively, whereas the CON group experienced a weight loss of −0.6%. No significant difference in primary outcome between groups was noted. However, our results indicate some benefits from exercise and nutrition for malnourished surgical patients. |
| first_indexed | 2024-03-09T03:59:25Z |
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| id | doaj.art-54eb4b7dac9746f792207b20fafe9d0e |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T03:59:25Z |
| publishDate | 2022-06-01 |
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| spelling | doaj.art-54eb4b7dac9746f792207b20fafe9d0e2023-12-03T14:15:55ZengMDPI AGNutrients2072-66432022-06-011413259910.3390/nu14132599Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled TrialPoula Patursson0Grith Møller1Bjartur Bernhardson Thomsen2Eyðfinnur Olsen3Jann Mortensen4Guðrið Andorsdóttir5Magni Mohr6Jens Rikardt Andersen7Department of Surgery, National Hospital of the Faroe Islands, J.C. Svabosgøta 41–49, 100 Torshavn, Faroe IslandsDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, DenmarkDepartment of Occupational and Physiotherapy, National Hospital of the Faroe Islands, J.C. Svabosgøta 41–49, 100 Torshavn, Faroe IslandsDepartment of Surgery, National Hospital of the Faroe Islands, J.C. Svabosgøta 41–49, 100 Torshavn, Faroe IslandsDepartment of Clinical Physiology, Nuclear Medicine & PET, Centre of Diagnostic Investigation, Copenhagen University Hospital, Blegdamsvej 9, 2100 Copenhagen, DenmarkThe Genetic Biobank of the Faroes, J.C. Svabosgøta 43, 100 Torshavn, Faroe IslandsCentre of Health Sciences, Faculty of Health, University of the Faroe Islands, Vestara Bryggja 15, 100 Torshavn, Faroe IslandsDepartment of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg, DenmarkThe presence of malnutrition is increasingly becoming a postdischarge problem in surgical patients. We aimed to investigate whether oral nutritional supplements combined with resistance training could minimize skeletal muscle atrophy in surgical patients after discharge. This randomized controlled study was conducted at the Department of Surgery, National Hospital of Faroe Islands from 2018 to 2020. A total of 45 patients aged 37–74 years participated and were allocated to one of three groups: diet (DI; <i>n</i> = 13), exercise and diet (EX + DI; <i>n</i> = 16), or control (CON; <i>n</i> = 16). The intervention period lasted 8 weeks. The intervention groups received individual dietary counselling and a protein-rich oral nutritional supplement twice a day containing 22 g of protein/day. Patients in the EX + DI group were assigned to resistance training sessions. Patients in the CON group received standard care. The primary outcome was change in lean body mass (LBM). Secondary outcomes were change in body weight, handgrip strength, quality of life, surgery-related side effects, energy and protein intake, length of stay and one-year mortality. To estimate within-group changes, linear mixed models including group–time interactions as fixed effects and patients as random effects were fitted. Within-group change in LBM was 233, 813 and 78 g in the DI, EX + DI and CON groups, respectively, with no significant between-group difference (<i>p</i> > 0.05). Pain score declined more (<i>p</i> = 0.04) in the EX + DI group compared with the CON group. Body weight, handgrip strength, quality of life and surgery-related side effects did not differ between groups. At the end of study, mean cumulative weight change in the DI and EX + DI groups was 0.4% and 1.6%, respectively, whereas the CON group experienced a weight loss of −0.6%. No significant difference in primary outcome between groups was noted. However, our results indicate some benefits from exercise and nutrition for malnourished surgical patients.https://www.mdpi.com/2072-6643/14/13/2599malnutritionsurgerypostdischargeresistance trainingoral nutritional supplements |
| spellingShingle | Poula Patursson Grith Møller Bjartur Bernhardson Thomsen Eyðfinnur Olsen Jann Mortensen Guðrið Andorsdóttir Magni Mohr Jens Rikardt Andersen Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial Nutrients malnutrition surgery postdischarge resistance training oral nutritional supplements |
| title | Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial |
| title_full | Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial |
| title_fullStr | Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial |
| title_full_unstemmed | Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial |
| title_short | Effects of Postdischarge High-Protein Oral Nutritional Supplements and Resistance Training in Malnourished Surgical Patients: A Pilot Randomized Controlled Trial |
| title_sort | effects of postdischarge high protein oral nutritional supplements and resistance training in malnourished surgical patients a pilot randomized controlled trial |
| topic | malnutrition surgery postdischarge resistance training oral nutritional supplements |
| url | https://www.mdpi.com/2072-6643/14/13/2599 |
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