Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway

Interleukin (IL)-25 suppresses IL-22-induced osteoclastogenesis in rheumatoid arthritis via STAT3 and p38 MAPK/IκBα pathway

Abstract Background The present study aimed to evaluate the suppressive role of interleukin (IL)-25 in IL-22-induced osteoclastogenesis and receptor activator of nuclear factor κB ligand (RANKL) expression in rheumatoid arthritis (RA). Methods Serum from patients with RA and osteoarthritis (OA), and...

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Bibliographic Details
Main Authors: Hong Ki Min, Ji-Yeon Won, Bo-Mi Kim, Kyung-Ann Lee, Seoung-Joon Lee, Sang-Heon Lee, Hae-Rim Kim, Kyoung-Woon Kim
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Arthritis Research & Therapy
Subjects:
Rheumatoid arthritis
Osteoclastogenesis
IL-22
IL-25
Online Access:http://link.springer.com/article/10.1186/s13075-020-02315-8

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