SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study
AbstractIntroduction Vaccination hesitancy is an important barrier to vaccination among IBD patients. The development of adverse events is the main concern reported. The purpose of this monocentric study was to assess SARS-CoV-2 vaccination safety in IBD patients by evaluating the postvaccination fl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2295979 |
| _version_ | 1797338610971705344 |
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| author | Laura N. Rossier Natalie P. Décosterd Christoph B. Matter Dominic A. Staudenmann André Moser Bernhard Egger Frank W. Seibold |
| author_facet | Laura N. Rossier Natalie P. Décosterd Christoph B. Matter Dominic A. Staudenmann André Moser Bernhard Egger Frank W. Seibold |
| author_sort | Laura N. Rossier |
| collection | DOAJ |
| description | AbstractIntroduction Vaccination hesitancy is an important barrier to vaccination among IBD patients. The development of adverse events is the main concern reported. The purpose of this monocentric study was to assess SARS-CoV-2 vaccination safety in IBD patients by evaluating the postvaccination flare risk and incidence of overall adverse events.Methods Surveys were handed out on three consecutive months to each patient presenting at the Crohn-Colitis Centre, where they documented their vaccination status and any side effects experienced after vaccination.Dates of flares occurring in 2021 were recorded from their electronic medical records. Baseline and IBD characteristics and flare incidence were compared between the vaccinated and unvaccinated patients, and among the vaccinated population before and after their vaccination doses. The characteristics of patients who developed side effects and of those who did not were compared.Results We enrolled 396 IBD patients, of whom 91% were vaccinated. The proportion of patients who experienced flares was statistically not different between the vaccinated and the unvaccinated population (1.8 vs 2.6 flares per 100 person-months (p = 0.28)). Among vaccinated patients, there was no difference across the prevaccination, 1 month post any vaccination, and more than 1 month after any vaccination periods, and between the Spikevax and Cominarty subgroups. Overall, 46% of patients reported vaccination side effects, mostly mild flu-like symptoms.Conclusion SARS-CoV-2 vaccination with mRNA vaccines seems safe, with mostly mild side effects. The IBD flare risk is not increased in the month following any vaccination. |
| first_indexed | 2024-03-08T09:33:47Z |
| format | Article |
| id | doaj.art-54ec8c2d83754b1f9837862dc11a44c1 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T09:33:47Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-54ec8c2d83754b1f9837862dc11a44c12024-01-30T13:37:11ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2023.2295979SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss studyLaura N. Rossier0Natalie P. Décosterd1Christoph B. Matter2Dominic A. Staudenmann3André Moser4Bernhard Egger5Frank W. Seibold6Intesto, Gastroenterology and Crohn-Colitis Center, Fribourg and Berne, SwitzerlandIntesto, Gastroenterology and Crohn-Colitis Center, Fribourg and Berne, SwitzerlandIntesto, Gastroenterology and Crohn-Colitis Center, Fribourg and Berne, SwitzerlandIntesto, Gastroenterology and Crohn-Colitis Center, Fribourg and Berne, SwitzerlandCTU Bern, University of Bern, SwitzerlandFaculty of Medicine, University of Fribourg, SwitzerlandIntesto, Gastroenterology and Crohn-Colitis Center, Fribourg and Berne, SwitzerlandAbstractIntroduction Vaccination hesitancy is an important barrier to vaccination among IBD patients. The development of adverse events is the main concern reported. The purpose of this monocentric study was to assess SARS-CoV-2 vaccination safety in IBD patients by evaluating the postvaccination flare risk and incidence of overall adverse events.Methods Surveys were handed out on three consecutive months to each patient presenting at the Crohn-Colitis Centre, where they documented their vaccination status and any side effects experienced after vaccination.Dates of flares occurring in 2021 were recorded from their electronic medical records. Baseline and IBD characteristics and flare incidence were compared between the vaccinated and unvaccinated patients, and among the vaccinated population before and after their vaccination doses. The characteristics of patients who developed side effects and of those who did not were compared.Results We enrolled 396 IBD patients, of whom 91% were vaccinated. The proportion of patients who experienced flares was statistically not different between the vaccinated and the unvaccinated population (1.8 vs 2.6 flares per 100 person-months (p = 0.28)). Among vaccinated patients, there was no difference across the prevaccination, 1 month post any vaccination, and more than 1 month after any vaccination periods, and between the Spikevax and Cominarty subgroups. Overall, 46% of patients reported vaccination side effects, mostly mild flu-like symptoms.Conclusion SARS-CoV-2 vaccination with mRNA vaccines seems safe, with mostly mild side effects. The IBD flare risk is not increased in the month following any vaccination.https://www.tandfonline.com/doi/10.1080/07853890.2023.2295979FlaresIBDSARS-CoV-2 vaccination |
| spellingShingle | Laura N. Rossier Natalie P. Décosterd Christoph B. Matter Dominic A. Staudenmann André Moser Bernhard Egger Frank W. Seibold SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study Annals of Medicine Flares IBD SARS-CoV-2 vaccination |
| title | SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study |
| title_full | SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study |
| title_fullStr | SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study |
| title_full_unstemmed | SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study |
| title_short | SARS-CoV-2 vaccination in inflammatory bowel disease patients is not associated with flares: a retrospective single-centre Swiss study |
| title_sort | sars cov 2 vaccination in inflammatory bowel disease patients is not associated with flares a retrospective single centre swiss study |
| topic | Flares IBD SARS-CoV-2 vaccination |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2295979 |
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