Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker
An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates pr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2009-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/14/10/3914/ |
| _version_ | 1818116553798844416 |
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| author | Dimitris Matiadis Kyriakos C. Prousis Olga Igglessi-Markopoulou |
| author_facet | Dimitris Matiadis Kyriakos C. Prousis Olga Igglessi-Markopoulou |
| author_sort | Dimitris Matiadis |
| collection | DOAJ |
| description | An efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product. |
| first_indexed | 2024-12-11T04:24:21Z |
| format | Article |
| id | doaj.art-54ecdf022ac946dab6e8478b0f1805e6 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-11T04:24:21Z |
| publishDate | 2009-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-54ecdf022ac946dab6e8478b0f1805e62022-12-22T01:21:02ZengMDPI AGMolecules1420-30492009-09-0114103914392110.3390/molecules14103914Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate LinkerDimitris MatiadisKyriakos C. ProusisOlga Igglessi-MarkopoulouAn efficient three-step solid-phase synthesis of diverse 3,5-disubstituted-2-aminofuranones has been developed. α-Hydroxy acids loaded on a nitrophenyl carbonate derivative of Wang resin are used as acylating agents for the C-acylation of active methylene compounds and the resulting intermediates provided, through a cyclative cleavage reaction, the desired product.http://www.mdpi.com/1420-3049/14/10/3914/2-aminofuranonessolid-phase synthesisheterocycleslactonesacylations |
| spellingShingle | Dimitris Matiadis Kyriakos C. Prousis Olga Igglessi-Markopoulou Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker Molecules 2-aminofuranones solid-phase synthesis heterocycles lactones acylations |
| title | Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker |
| title_full | Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker |
| title_fullStr | Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker |
| title_full_unstemmed | Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker |
| title_short | Solid-Phase Synthesis of Optically Active Substituted 2 Aminofuranones Using an Activated Carbonate Linker |
| title_sort | solid phase synthesis of optically active substituted 2 aminofuranones using an activated carbonate linker |
| topic | 2-aminofuranones solid-phase synthesis heterocycles lactones acylations |
| url | http://www.mdpi.com/1420-3049/14/10/3914/ |
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