Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis
<p>Abstract</p> <p>Background</p> <p>There are few reports on the nutritional status changes and residual renal function (RRF) according to proteinuria levels in patients on peritoneal dialysis (PD).</p> <p>Methods</p> <p>A total of 388 patients...
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| Format: | Article |
| Language: | English |
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BMC
2012-12-01
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| Series: | BMC Nephrology |
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| Online Access: | http://www.biomedcentral.com/1471-2369/13/171 |
| _version_ | 1819036098198765568 |
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| author | Kang Seok Hui Cho Kyu Hyang Park Jong Won Yoon Kyung Woo Do Jun Young |
| author_facet | Kang Seok Hui Cho Kyu Hyang Park Jong Won Yoon Kyung Woo Do Jun Young |
| author_sort | Kang Seok Hui |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>There are few reports on the nutritional status changes and residual renal function (RRF) according to proteinuria levels in patients on peritoneal dialysis (PD).</p> <p>Methods</p> <p>A total of 388 patients on PD were enrolled. The patients were divided into 3 groups with respect to initial proteinuria: the A (n = 119; <500 mg/day), B (n = 218; 500–3,500 mg/day), and C groups (n = 51; >3,500 mg/day).</p> <p>Results</p> <p>The patients with higher proteinuria levels had a higher incidence of male sex, diabetes mellitus, and icodextrin use than those with lower proteinuria levels. Although initial peritoneal albumin loss in C group was lower than that detected in the other groups, no significant difference was observed in peritoneal albumin loss among the 3 groups at the end of follow-up period. At the time of PD initiation, the Geriatric nutritional risk index (GNRI) was lower in the C group than in the other 2 groups. However, at the end of the follow-up period, there was no significant difference in GNRI between the 3 groups. The GNRI increased, and the proteinuria level or RRF decreased more in the C group than in the other 2 groups. There were no significant differences in lean mass index or fat mass index change from the time of PD initiation to the end of the follow-up period. However, fat mass index and nPNA showed greater increases in the C group. The multivariate analysis revealed that proteinuria was negatively correlated with GNRI at the time of PD initiation and at the end of the follow-up period. The initial RRF and proteinuria were negatively correlated with the RRF decline during the follow-up.</p> <p>Conclusion</p> <p>The attenuation of the nephrotic proteinuria, along with the RRF decline, was associated with the improvement of the malnutrition.</p> |
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| format | Article |
| id | doaj.art-54ede77fab8a456bbb242856dcceb48f |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-12-21T08:00:07Z |
| publishDate | 2012-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-54ede77fab8a456bbb242856dcceb48f2022-12-21T19:10:55ZengBMCBMC Nephrology1471-23692012-12-0113117110.1186/1471-2369-13-171Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysisKang Seok HuiCho Kyu HyangPark Jong WonYoon Kyung WooDo Jun Young<p>Abstract</p> <p>Background</p> <p>There are few reports on the nutritional status changes and residual renal function (RRF) according to proteinuria levels in patients on peritoneal dialysis (PD).</p> <p>Methods</p> <p>A total of 388 patients on PD were enrolled. The patients were divided into 3 groups with respect to initial proteinuria: the A (n = 119; <500 mg/day), B (n = 218; 500–3,500 mg/day), and C groups (n = 51; >3,500 mg/day).</p> <p>Results</p> <p>The patients with higher proteinuria levels had a higher incidence of male sex, diabetes mellitus, and icodextrin use than those with lower proteinuria levels. Although initial peritoneal albumin loss in C group was lower than that detected in the other groups, no significant difference was observed in peritoneal albumin loss among the 3 groups at the end of follow-up period. At the time of PD initiation, the Geriatric nutritional risk index (GNRI) was lower in the C group than in the other 2 groups. However, at the end of the follow-up period, there was no significant difference in GNRI between the 3 groups. The GNRI increased, and the proteinuria level or RRF decreased more in the C group than in the other 2 groups. There were no significant differences in lean mass index or fat mass index change from the time of PD initiation to the end of the follow-up period. However, fat mass index and nPNA showed greater increases in the C group. The multivariate analysis revealed that proteinuria was negatively correlated with GNRI at the time of PD initiation and at the end of the follow-up period. The initial RRF and proteinuria were negatively correlated with the RRF decline during the follow-up.</p> <p>Conclusion</p> <p>The attenuation of the nephrotic proteinuria, along with the RRF decline, was associated with the improvement of the malnutrition.</p>http://www.biomedcentral.com/1471-2369/13/171Peritoneal dialysisProteinuriaResidual renal functionNutrition |
| spellingShingle | Kang Seok Hui Cho Kyu Hyang Park Jong Won Yoon Kyung Woo Do Jun Young Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis BMC Nephrology Peritoneal dialysis Proteinuria Residual renal function Nutrition |
| title | Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis |
| title_full | Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis |
| title_fullStr | Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis |
| title_full_unstemmed | Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis |
| title_short | Impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis |
| title_sort | impact of heavy proteinuria on clinical outcomes in patients on incident peritoneal dialysis |
| topic | Peritoneal dialysis Proteinuria Residual renal function Nutrition |
| url | http://www.biomedcentral.com/1471-2369/13/171 |
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