A high affinity switch for cAMP in the HCN pacemaker channels

A high affinity switch for cAMP in the HCN pacemaker channels

Abstract Binding of cAMP to Hyperpolarization activated cyclic nucleotide gated (HCN) channels facilitates pore opening. It is unclear why the isolated cyclic nucleotide binding domain (CNBD) displays in vitro lower affinity for cAMP than the full-length channel in patch experiments. Here we show th...

Detaylı Bibliyografya
Asıl Yazarlar:	Alessandro Porro, Andrea Saponaro, Roberta Castelli, Bianca Introini, Anahita Hafez Alkotob, Golnaz Ranjbari, Uta Enke, Jana Kusch, Klaus Benndorf, Bina Santoro, Dario DiFrancesco, Gerhard Thiel, Anna Moroni
Materyal Türü:	Makale
Dil:	English
Baskı/Yayın Bilgisi:	Nature Portfolio 2024-01-01
Seri Bilgileri:	Nature Communications
Online Erişim:	https://doi.org/10.1038/s41467-024-45136-y

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