Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research
Wound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal pro...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/11/3566 |
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| author | Stefania Vitale Sara Colanero Martina Placidi Giovanna Di Emidio Carla Tatone Fernanda Amicarelli Anna Maria D’Alessandro |
| author_facet | Stefania Vitale Sara Colanero Martina Placidi Giovanna Di Emidio Carla Tatone Fernanda Amicarelli Anna Maria D’Alessandro |
| author_sort | Stefania Vitale |
| collection | DOAJ |
| description | Wound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal products. The aim of the present study is to summarize the most recent in vitro, in vivo, and clinical studies on major herbal preparations, their phytochemical constituents, and new formulations for wound management. Research reveals that several herbal medicaments have marked activity in the management of wounds and that this activity is ascribed to flavonoids, alkaloids, saponins, and phenolic compounds. These phytochemicals can act at different stages of the process by means of various mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulating, cell proliferation, and angiogenic effects. The application of natural compounds using nanotechnology systems may provide significant improvement in the efficacy of wound treatments. Increasing the clinical use of these therapies would require safety assessment in clinical trials. |
| first_indexed | 2024-03-10T01:03:30Z |
| format | Article |
| id | doaj.art-54ef91f6bb0c4420b714048c8df87e3c |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T01:03:30Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-54ef91f6bb0c4420b714048c8df87e3c2023-11-23T14:30:52ZengMDPI AGMolecules1420-30492022-06-012711356610.3390/molecules27113566Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current ResearchStefania Vitale0Sara Colanero1Martina Placidi2Giovanna Di Emidio3Carla Tatone4Fernanda Amicarelli5Anna Maria D’Alessandro6Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Biosciences, University of Milan, Via Giovanni Celoria 26, 20133 Milan, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyDepartment of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, ItalyWound healing is a complicated process, and the effective management of wounds is a major challenge. Natural herbal remedies have now become fundamental for the management of skin disorders and the treatment of skin infections due to the side effects of modern medicine and lower price for herbal products. The aim of the present study is to summarize the most recent in vitro, in vivo, and clinical studies on major herbal preparations, their phytochemical constituents, and new formulations for wound management. Research reveals that several herbal medicaments have marked activity in the management of wounds and that this activity is ascribed to flavonoids, alkaloids, saponins, and phenolic compounds. These phytochemicals can act at different stages of the process by means of various mechanisms, including anti-inflammatory, antimicrobial, antioxidant, collagen synthesis stimulating, cell proliferation, and angiogenic effects. The application of natural compounds using nanotechnology systems may provide significant improvement in the efficacy of wound treatments. Increasing the clinical use of these therapies would require safety assessment in clinical trials.https://www.mdpi.com/1420-3049/27/11/3566wound healingherbsmedicinal plantssecondary metabolitesnatural wound dressingskin disorders |
| spellingShingle | Stefania Vitale Sara Colanero Martina Placidi Giovanna Di Emidio Carla Tatone Fernanda Amicarelli Anna Maria D’Alessandro Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research Molecules wound healing herbs medicinal plants secondary metabolites natural wound dressing skin disorders |
| title | Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research |
| title_full | Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research |
| title_fullStr | Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research |
| title_full_unstemmed | Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research |
| title_short | Phytochemistry and Biological Activity of Medicinal Plants in Wound Healing: An Overview of Current Research |
| title_sort | phytochemistry and biological activity of medicinal plants in wound healing an overview of current research |
| topic | wound healing herbs medicinal plants secondary metabolites natural wound dressing skin disorders |
| url | https://www.mdpi.com/1420-3049/27/11/3566 |
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