SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population.
Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed.The aim of this study was t...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3774761?pdf=render |
| _version_ | 1819098911999000576 |
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| author | Iva Kirac Petar Matošević Goran Augustin Iva Šimunović Vedran Hostić Sven Župančić Caroline Hayward Natasa Antoljak Igor Rudan Harry Campbell Malcolm G Dunlop Danko Velimir Vrdoljak Dujo Kovačević Lina Zgaga |
| author_facet | Iva Kirac Petar Matošević Goran Augustin Iva Šimunović Vedran Hostić Sven Župančić Caroline Hayward Natasa Antoljak Igor Rudan Harry Campbell Malcolm G Dunlop Danko Velimir Vrdoljak Dujo Kovačević Lina Zgaga |
| author_sort | Iva Kirac |
| collection | DOAJ |
| description | Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed.The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population.An association study was performed on 320 colorectal cancer cases and 594 controls recruited in Croatia. We genotyped four variants previously associated with CRC: rs10795668, rs16892766, rs3802842 and rs4939827.SMAD7 variant rs4939827 (18q21.1) was significantly associated with CRC risk in Croatian population. C allele was associated with a decreased risk, odds ratio (OR): 0.70 (95% CI: 0.57-0.85, P=3.5E-04). Compared to TT homozygotes, risk was reduced by 34% in heterozygotes (OR=0.66, 95% CI: 0.47-0.92) and by 52% in CC homozygotes (OR=0.48, 95% CI: 0.33-0.72).Our results show association of rs4939827 with colorectal cancer risk in Croatian population. The higher strength of the association in comparison to other studies suggests population-specific environmental or genetic factors may be modifying the association. More studies are needed to further describe role of rs4939827 in CRC. Likely reason for failure of replication for other 3 loci is inadequate study power. |
| first_indexed | 2024-12-22T00:38:31Z |
| format | Article |
| id | doaj.art-54efeb28442e42a8a803c38fb436b6b9 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T00:38:31Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-54efeb28442e42a8a803c38fb436b6b92022-12-21T18:44:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0189e7404210.1371/journal.pone.0074042SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population.Iva KiracPetar MatoševićGoran AugustinIva ŠimunovićVedran HostićSven ŽupančićCaroline HaywardNatasa AntoljakIgor RudanHarry CampbellMalcolm G DunlopDanko Velimir VrdoljakDujo KovačevićLina ZgagaTwenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability of findings to any specific population needs to be confirmed.The aim of this study was to perform an association study between risk variants: rs10795668, rs16892766, rs3802842 and rs4939827 and CRC risk in Croatian population.An association study was performed on 320 colorectal cancer cases and 594 controls recruited in Croatia. We genotyped four variants previously associated with CRC: rs10795668, rs16892766, rs3802842 and rs4939827.SMAD7 variant rs4939827 (18q21.1) was significantly associated with CRC risk in Croatian population. C allele was associated with a decreased risk, odds ratio (OR): 0.70 (95% CI: 0.57-0.85, P=3.5E-04). Compared to TT homozygotes, risk was reduced by 34% in heterozygotes (OR=0.66, 95% CI: 0.47-0.92) and by 52% in CC homozygotes (OR=0.48, 95% CI: 0.33-0.72).Our results show association of rs4939827 with colorectal cancer risk in Croatian population. The higher strength of the association in comparison to other studies suggests population-specific environmental or genetic factors may be modifying the association. More studies are needed to further describe role of rs4939827 in CRC. Likely reason for failure of replication for other 3 loci is inadequate study power.http://europepmc.org/articles/PMC3774761?pdf=render |
| spellingShingle | Iva Kirac Petar Matošević Goran Augustin Iva Šimunović Vedran Hostić Sven Župančić Caroline Hayward Natasa Antoljak Igor Rudan Harry Campbell Malcolm G Dunlop Danko Velimir Vrdoljak Dujo Kovačević Lina Zgaga SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. PLoS ONE |
| title | SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. |
| title_full | SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. |
| title_fullStr | SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. |
| title_full_unstemmed | SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. |
| title_short | SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population. |
| title_sort | smad7 variant rs4939827 is associated with colorectal cancer risk in croatian population |
| url | http://europepmc.org/articles/PMC3774761?pdf=render |
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