Extracellular Vesicles: A Double-Edged Sword in Sepsis
Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Several studies on mouse and patient sepsis samples have revealed that the level of extracellular vesicles (EVs) in the blood is altered compared to healthy controls, but the different f...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/8/829 |
| _version_ | 1797522425940803584 |
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| author | Marlies Burgelman Charysse Vandendriessche Roosmarijn E. Vandenbroucke |
| author_facet | Marlies Burgelman Charysse Vandendriessche Roosmarijn E. Vandenbroucke |
| author_sort | Marlies Burgelman |
| collection | DOAJ |
| description | Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Several studies on mouse and patient sepsis samples have revealed that the level of extracellular vesicles (EVs) in the blood is altered compared to healthy controls, but the different functions of EVs during sepsis pathology are not yet completely understood. Sepsis EVs are described as modulators of inflammation, lymphocyte apoptosis, coagulation and organ dysfunction. Furthermore, EVs can influence clinical outcome and it is suggested that EVs can predict survival. Both detrimental and beneficial roles for EVs have been described in sepsis, depending on the EV cellular source and the disease phase during which the EVs are studied. In this review, we summarize the current knowledge of EV sources and functions during sepsis pathology based on in vitro and mouse models, as well as patient samples. |
| first_indexed | 2024-03-10T08:29:12Z |
| format | Article |
| id | doaj.art-54f14c6fce534c4db2df591a12d195ff |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T08:29:12Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-54f14c6fce534c4db2df591a12d195ff2023-11-22T09:12:27ZengMDPI AGPharmaceuticals1424-82472021-08-0114882910.3390/ph14080829Extracellular Vesicles: A Double-Edged Sword in SepsisMarlies Burgelman0Charysse Vandendriessche1Roosmarijn E. Vandenbroucke2VIB Center for Inflammation Research, 9052 Ghent, BelgiumVIB Center for Inflammation Research, 9052 Ghent, BelgiumVIB Center for Inflammation Research, 9052 Ghent, BelgiumSepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection. Several studies on mouse and patient sepsis samples have revealed that the level of extracellular vesicles (EVs) in the blood is altered compared to healthy controls, but the different functions of EVs during sepsis pathology are not yet completely understood. Sepsis EVs are described as modulators of inflammation, lymphocyte apoptosis, coagulation and organ dysfunction. Furthermore, EVs can influence clinical outcome and it is suggested that EVs can predict survival. Both detrimental and beneficial roles for EVs have been described in sepsis, depending on the EV cellular source and the disease phase during which the EVs are studied. In this review, we summarize the current knowledge of EV sources and functions during sepsis pathology based on in vitro and mouse models, as well as patient samples.https://www.mdpi.com/1424-8247/14/8/829extracellular vesiclessepsisinflammation |
| spellingShingle | Marlies Burgelman Charysse Vandendriessche Roosmarijn E. Vandenbroucke Extracellular Vesicles: A Double-Edged Sword in Sepsis Pharmaceuticals extracellular vesicles sepsis inflammation |
| title | Extracellular Vesicles: A Double-Edged Sword in Sepsis |
| title_full | Extracellular Vesicles: A Double-Edged Sword in Sepsis |
| title_fullStr | Extracellular Vesicles: A Double-Edged Sword in Sepsis |
| title_full_unstemmed | Extracellular Vesicles: A Double-Edged Sword in Sepsis |
| title_short | Extracellular Vesicles: A Double-Edged Sword in Sepsis |
| title_sort | extracellular vesicles a double edged sword in sepsis |
| topic | extracellular vesicles sepsis inflammation |
| url | https://www.mdpi.com/1424-8247/14/8/829 |
| work_keys_str_mv | AT marliesburgelman extracellularvesiclesadoubleedgedswordinsepsis AT charyssevandendriessche extracellularvesiclesadoubleedgedswordinsepsis AT roosmarijnevandenbroucke extracellularvesiclesadoubleedgedswordinsepsis |