Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants
Association Between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants. Objective: To determine whether higher weight-to-length z-scores after 32 weeks of gestation are associated with higher pulmonary scores (PSs) in preterm infants requiring respiratory support using a...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/11/1/91 |
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| author | Pradeep Alur Kristen Harvey Kyle Hart Wondwosen K. Yimer Renjithkumar Kalikkot Thekkeveedu |
| author_facet | Pradeep Alur Kristen Harvey Kyle Hart Wondwosen K. Yimer Renjithkumar Kalikkot Thekkeveedu |
| author_sort | Pradeep Alur |
| collection | DOAJ |
| description | Association Between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants. Objective: To determine whether higher weight-to-length z-scores after 32 weeks of gestation are associated with higher pulmonary scores (PSs) in preterm infants requiring respiratory support using a prospective observational study. Methods: Infants born at <30 weeks, with a post-menstrual age (PMA) of 30–33 weeks, were enrolled. The infant’s weight, length, and head circumference were measured weekly. Data on calories/kg/d, protein g/kg/d, weight-for-length percentiles, z-scores, and BMI at 33 through 40 weeks PMA were collected. The PS was calculated. Results: We analyzed 91 infants. The mean gestational age was 26.9 ± 1.7 weeks. The mean birthweight was 0.898 ± 0.238 kgs. They were predominantly African American (81.3%) and girls (56%). Postnatal steroids were administered in 26.4% of the infants. The mean duration of invasive ventilation was 19.23 days ± 28.30 days. There was a significant association between the PS and W/L z-score (<i>p</i> < 0.0001). For every one-unit increase in W/L z-score, the PS increased by 0.063. There was a significant association between the PS and W/L percentile (<i>p</i> = 0.0017), as well as BMI (<i>p</i> ≤ 0.0001). For every unit increase in W/L percentile, the PS increased by 0.002, and for a unit increase in BMI, the PS increased by 0.04. The association remained significant after postnatal steroid use, sex, and corrected and birth gestational ages were included in the regression analysis. Nutrition did not affect the anthropometric measurements. Conclusions: Our study is the first to demonstrate that a higher BMI and W/L may adversely affect the respiratory severity in preterm infants. Studies with larger sample sizes are needed to confirm our findings. |
| first_indexed | 2024-03-08T11:01:06Z |
| format | Article |
| id | doaj.art-54f360db357f461e90f8b838ac827833 |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-08T11:01:06Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-54f360db357f461e90f8b838ac8278332024-01-26T15:48:46ZengMDPI AGChildren2227-90672024-01-011119110.3390/children11010091Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm InfantsPradeep Alur0Kristen Harvey1Kyle Hart2Wondwosen K. Yimer3Renjithkumar Kalikkot Thekkeveedu4Hampden Medical Center, Penn State Health, Harrisburg, PA 17025, USASchool of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USASchool of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Data Sciences, University of Mississippi Medical Center, Jackson, MS 39216, USADepartment of Pediatrics, Deaconess Women’s Hospital, Newburgh, IN 47630, USAAssociation Between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants. Objective: To determine whether higher weight-to-length z-scores after 32 weeks of gestation are associated with higher pulmonary scores (PSs) in preterm infants requiring respiratory support using a prospective observational study. Methods: Infants born at <30 weeks, with a post-menstrual age (PMA) of 30–33 weeks, were enrolled. The infant’s weight, length, and head circumference were measured weekly. Data on calories/kg/d, protein g/kg/d, weight-for-length percentiles, z-scores, and BMI at 33 through 40 weeks PMA were collected. The PS was calculated. Results: We analyzed 91 infants. The mean gestational age was 26.9 ± 1.7 weeks. The mean birthweight was 0.898 ± 0.238 kgs. They were predominantly African American (81.3%) and girls (56%). Postnatal steroids were administered in 26.4% of the infants. The mean duration of invasive ventilation was 19.23 days ± 28.30 days. There was a significant association between the PS and W/L z-score (<i>p</i> < 0.0001). For every one-unit increase in W/L z-score, the PS increased by 0.063. There was a significant association between the PS and W/L percentile (<i>p</i> = 0.0017), as well as BMI (<i>p</i> ≤ 0.0001). For every unit increase in W/L percentile, the PS increased by 0.002, and for a unit increase in BMI, the PS increased by 0.04. The association remained significant after postnatal steroid use, sex, and corrected and birth gestational ages were included in the regression analysis. Nutrition did not affect the anthropometric measurements. Conclusions: Our study is the first to demonstrate that a higher BMI and W/L may adversely affect the respiratory severity in preterm infants. Studies with larger sample sizes are needed to confirm our findings.https://www.mdpi.com/2227-9067/11/1/91pretermweightlengthBMIBPD |
| spellingShingle | Pradeep Alur Kristen Harvey Kyle Hart Wondwosen K. Yimer Renjithkumar Kalikkot Thekkeveedu Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants Children preterm weight length BMI BPD |
| title | Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants |
| title_full | Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants |
| title_fullStr | Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants |
| title_full_unstemmed | Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants |
| title_short | Association between Weight for Length and the Severity of Respiratory Morbidity in Preterm Infants |
| title_sort | association between weight for length and the severity of respiratory morbidity in preterm infants |
| topic | preterm weight length BMI BPD |
| url | https://www.mdpi.com/2227-9067/11/1/91 |
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