Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase
Current treatments for toxoplasmosis are limited by adverse reactions and inability to cure chronic infections dominated by semi-dormant cyst forms. Here the authors demonstrate the potential of small molecule inhibitors of PheRS for controlling acute and chronic toxoplasmosis.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-28108-y |
| _version_ | 1819280394466361344 |
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| author | Joshua B. Radke Bruno Melillo Payal Mittal Manmohan Sharma Amit Sharma Yong Fu Taher Uddin Arthur Gonse Eamon Comer Stuart L. Schreiber Anil K. Gupta Arnab K. Chatterjee L. David Sibley |
| author_facet | Joshua B. Radke Bruno Melillo Payal Mittal Manmohan Sharma Amit Sharma Yong Fu Taher Uddin Arthur Gonse Eamon Comer Stuart L. Schreiber Anil K. Gupta Arnab K. Chatterjee L. David Sibley |
| author_sort | Joshua B. Radke |
| collection | DOAJ |
| description | Current treatments for toxoplasmosis are limited by adverse reactions and inability to cure chronic infections dominated by semi-dormant cyst forms. Here the authors demonstrate the potential of small molecule inhibitors of PheRS for controlling acute and chronic toxoplasmosis. |
| first_indexed | 2024-12-24T00:43:06Z |
| format | Article |
| id | doaj.art-54f3e31953f543ac83275cd23bb755ea |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-24T00:43:06Z |
| publishDate | 2022-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-54f3e31953f543ac83275cd23bb755ea2022-12-21T17:23:52ZengNature PortfolioNature Communications2041-17232022-01-0113111310.1038/s41467-022-28108-yBicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetaseJoshua B. Radke0Bruno Melillo1Payal Mittal2Manmohan Sharma3Amit Sharma4Yong Fu5Taher Uddin6Arthur Gonse7Eamon Comer8Stuart L. Schreiber9Anil K. Gupta10Arnab K. Chatterjee11L. David Sibley12Department of Molecular Microbiology, Washington University Sch. Med.Department of Chemistry, The Scripps Research InstituteMolecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and BiotechnologyMolecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and BiotechnologyMolecular Medicine-Structural Parasitology Group, International Centre for Genetic Engineering and BiotechnologyDepartment of Molecular Microbiology, Washington University Sch. Med.Department of Molecular Microbiology, Washington University Sch. Med.Chemical Biology and Therapeutics Science Program, Broad InstituteChemical Biology and Therapeutics Science Program, Broad InstituteChemical Biology and Therapeutics Science Program, Broad InstituteDepartment of Chemistry, The Scripps Research InstituteDepartment of Chemistry, The Scripps Research InstituteDepartment of Molecular Microbiology, Washington University Sch. Med.Current treatments for toxoplasmosis are limited by adverse reactions and inability to cure chronic infections dominated by semi-dormant cyst forms. Here the authors demonstrate the potential of small molecule inhibitors of PheRS for controlling acute and chronic toxoplasmosis.https://doi.org/10.1038/s41467-022-28108-y |
| spellingShingle | Joshua B. Radke Bruno Melillo Payal Mittal Manmohan Sharma Amit Sharma Yong Fu Taher Uddin Arthur Gonse Eamon Comer Stuart L. Schreiber Anil K. Gupta Arnab K. Chatterjee L. David Sibley Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase Nature Communications |
| title | Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase |
| title_full | Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase |
| title_fullStr | Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase |
| title_full_unstemmed | Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase |
| title_short | Bicyclic azetidines target acute and chronic stages of Toxoplasma gondii by inhibiting parasite phenylalanyl t-RNA synthetase |
| title_sort | bicyclic azetidines target acute and chronic stages of toxoplasma gondii by inhibiting parasite phenylalanyl t rna synthetase |
| url | https://doi.org/10.1038/s41467-022-28108-y |
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