Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population
Abstract Background This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing factors. Methods This study, a cohort study among a rural Chinese hyper...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-12-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-02082-1 |
| _version_ | 1797388537663848448 |
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| author | Nan Zhang Xiying Chi Ziyi Zhou Yun Song Shuqun Li Jiafeng Xu Jianping Li |
| author_facet | Nan Zhang Xiying Chi Ziyi Zhou Yun Song Shuqun Li Jiafeng Xu Jianping Li |
| author_sort | Nan Zhang |
| collection | DOAJ |
| description | Abstract Background This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing factors. Methods This study, a cohort study among a rural Chinese hypertensive population, utilized data from the China Stroke Primary Prevention Trial (CSPPT). The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate analysis using Cox proportional hazards models was conducted. Results A total of 7569 hypertensive patients were included in this study. When TyG index was assessed as quartiles, compared with the reference group (Quartile 1), the hazard ratio of stroke was 1.04 in Quartile 2, 1.43 in Quartile 3, and 1.45 in Quartile 4, with a significant trend test (P = 0.013). When Quartiles 3 and 4 were combined (≥ 8.8), the hazard ratio was 1.41 compared with combined Quartiles 1 and 2 (< 8.8). Similar findings were observed for the association of TyG index with ischemic stroke. Further, a joint effect of baseline TyG index and age on first stroke was found. Using the group with TyG < 8.8 and age < 60 years as a reference, the highest hazard ratio of stroke was found in the group with a higher TyG index and aged 60 or greater (HR: 2.15, 95% CI 1.50, 3.07, P < 0.001). Conclusions In a hypertensive population, baseline TyG index was associated with a significantly higher risk of first stroke. In addition, age was a significant effect modifier for this association. |
| first_indexed | 2024-03-08T22:42:16Z |
| format | Article |
| id | doaj.art-54f65a3b3e7a484395a402160513fa99 |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-08T22:42:16Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-54f65a3b3e7a484395a402160513fa992023-12-17T12:05:52ZengBMCCardiovascular Diabetology1475-28402023-12-012211810.1186/s12933-023-02082-1Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive populationNan Zhang0Xiying Chi1Ziyi Zhou2Yun Song3Shuqun Li4Jiafeng Xu5Jianping Li6Department of Cardiology, Peking University First HospitalDepartment of Cardiology, Peking University First HospitalTsinghua Shenzhen International Graduate School, Tsinghua UniversityShenzhen Evergreen Medical InstituteDepartment of Gastrointestinal Surgery, Beijing Shijitan Hospital, Capital Medical UniversityDepartment of Epidemiology, School of Public Health, Southern Medical UniversityDepartment of Cardiology, Peking University First HospitalAbstract Background This study aimed to evaluate the association of triglyceride-glucose (TyG) index, an insulin resistance surrogate biomarker, with first stroke in a hypertensive population and to explore potential influencing factors. Methods This study, a cohort study among a rural Chinese hypertensive population, utilized data from the China Stroke Primary Prevention Trial (CSPPT). The TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. Multivariate analysis using Cox proportional hazards models was conducted. Results A total of 7569 hypertensive patients were included in this study. When TyG index was assessed as quartiles, compared with the reference group (Quartile 1), the hazard ratio of stroke was 1.04 in Quartile 2, 1.43 in Quartile 3, and 1.45 in Quartile 4, with a significant trend test (P = 0.013). When Quartiles 3 and 4 were combined (≥ 8.8), the hazard ratio was 1.41 compared with combined Quartiles 1 and 2 (< 8.8). Similar findings were observed for the association of TyG index with ischemic stroke. Further, a joint effect of baseline TyG index and age on first stroke was found. Using the group with TyG < 8.8 and age < 60 years as a reference, the highest hazard ratio of stroke was found in the group with a higher TyG index and aged 60 or greater (HR: 2.15, 95% CI 1.50, 3.07, P < 0.001). Conclusions In a hypertensive population, baseline TyG index was associated with a significantly higher risk of first stroke. In addition, age was a significant effect modifier for this association.https://doi.org/10.1186/s12933-023-02082-1Triglyceride-glucose indexStrokeAge |
| spellingShingle | Nan Zhang Xiying Chi Ziyi Zhou Yun Song Shuqun Li Jiafeng Xu Jianping Li Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population Cardiovascular Diabetology Triglyceride-glucose index Stroke Age |
| title | Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population |
| title_full | Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population |
| title_fullStr | Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population |
| title_full_unstemmed | Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population |
| title_short | Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population |
| title_sort | triglyceride glucose index is associated with a higher risk of stroke in a hypertensive population |
| topic | Triglyceride-glucose index Stroke Age |
| url | https://doi.org/10.1186/s12933-023-02082-1 |
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