Antileishmanial Activity of BNIPDaoct- and BNIPDanon-loaded Emulsomes on Leishmania infantum Parasites

Antileishmanial Activity of BNIPDaoct- and BNIPDanon-loaded Emulsomes on Leishmania infantum Parasites

Among bisnaphthalimidopropyl (BNIP) derivatives, BNIPDaoct and BNIPDanon recently came forward with antileishmanial activities beyond the standard, commercialized antileishmanial therapies. However, high-level toxicity on macrophages plus poor aqueous solubility and poor bioavailability of the compo...

Full description

Bibliographic Details
Main Authors:	Zeynep Islek, Mehmet Hikmet Ucisik, Elif Keskin, Bilgesu Onur Sucu, Ana G. Gomes‐Alves, Ana M. Tomás, Mustafa Guzel, Fikrettin Sahin
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-01-01
Series:	Frontiers in Nanotechnology
Subjects:	bisnapthalimidopropyl (BNIP) derivatives Leishmania infantum nanocarrier emulsome antileishmanial therapy infected macrophages
Online Access:	https://www.frontiersin.org/articles/10.3389/fnano.2021.773741/full

Similar Items

Curcumin- and Piperine-Loaded Emulsomes as Combinational Treatment Approach Enhance the Anticancer Activity of Curcumin on HCT116 Colorectal Cancer Model
by: Zeynep Busra Bolat, et al.
Published: (2020-02-01)

Repurposing of atorvastatin emulsomes as a topical antifungal agent
by: Alaa S. Eita, et al.
Published: (2022-12-01)

Atorvastatin-loaded emulsomes foam as a topical antifungal formulation
by: Alaa S. Eita, et al.
Published: (2022-12-01)

The Encapsulation of Febuxostat into Emulsomes Strongly Enhances the Cytotoxic Potential of the Drug on HCT 116 Colon Cancer Cells
by: Usama A. Fahmy, et al.
Published: (2020-10-01)

Emulsomes: new lipidic carriers for drug delivery with special mention to brain drug transport
by: Shivam Singh, et al.
Published: (2023-09-01)

Neuroprotective Effects of Curcumin-Loaded Emulsomes in a Laser Axotomy-Induced CNS Injury Model
by: Yilmaz EN, et al.
Published: (2020-11-01)

The Enhanced Cytotoxic and Pro-Apoptotic Effects of Optimized Simvastatin-Loaded Emulsomes on MCF-7 Breast Cancer Cells
by: Zuhier A. Awan, et al.
Published: (2020-06-01)

Potential of Novel Methyl Jasmonate Analogs as Anticancer Agents to Metabolically Target HK-2 Activity in Glioblastoma Cells
by: Damla Uludağ, et al.
Published: (2022-05-01)

Piceatannol-Loaded Emulsomes Exhibit Enhanced Cytostatic and Apoptotic Activities in Colon Cancer Cells
by: Nabil A. Alhakamy, et al.
Published: (2020-05-01)

Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo pharmacokinetic assessment
by: Hibah M. Aldawsari, et al.
Published: (2022-08-01)

Assessment of Nasal-Brain-Targeting Efficiency of New Developed Mucoadhesive Emulsomes Encapsulating an Anti-Migraine Drug for Effective Treatment of One of the Major Psychiatric Disorders Symptoms
by: Hadel A. Abo El-Enin, et al.
Published: (2022-02-01)

Characterization of gas tunnel type plasma sprayed hydroxyapatite-nanostructure titania composite coatings
by: Yugeswaran, S., et al.
Published: (2015)

Lipidic Nano-Sized Emulsomes Potentiates the Cytotoxic and Apoptotic Effects of Raloxifene Hydrochloride in MCF-7 Human Breast Cancer Cells: Factorial Analysis and In Vitro Anti-Tumor Activity Assessment
by: Hibah M. Aldawsari, et al.
Published: (2021-05-01)

Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies
by: Ahmed A. Al-Karmalawy, et al.
Published: (2023-12-01)

Optimized Apamin-Mediated Nano-Lipidic Carrier Potentially Enhances the Cytotoxicity of Ellagic Acid against Human Breast Cancer Cells
by: Shaimaa M. Badr-Eldin, et al.
Published: (2022-08-01)

The Common Point of Countries Successful Policies in the Struggle Against COVID-19: Women Leaders
by: Süheyla Üçışık Erbilen, et al.
Published: (2023-06-01)

A SPECIAL SPECIES BETWEEN THE JOY PLANTS GROWN IN TURKEY: HOP (Humulus lupulus L.)
by: Süheyla ÜÇIŞIK ERBİLEN, et al.
Published: (2012-12-01)

DEVELOPMENT OF GREENHOUSE CULTIVATION AND ITS PROBLEMS IN T.R.N.C.
by: Güven ŞAHİN, et al.
Published: (2011-12-01)

THE CURRENT SITUATION, ISSUES AND POSSIBLE SOLUTIONS OF THE FISHERIES IN THE TRNC
by: Süheyla Üçışık Erbilen, et al.
Published: (2014-04-01)

The histone H3K9 demethylase KDM3A promotes anoikis by transcriptionally activating pro-apoptotic genes BNIP3 and BNIP3L
by: Victoria E Pedanou, et al.
Published: (2016-07-01)

DNA methylation of the promoter region of bnip3 and bnip3l genes induced by metabolic programming
by: Vincent Veron, et al.
Published: (2018-09-01)

A review on lipid-based nanocarriers mimicking chylomicron and their potential in drug delivery and targeting infectious and cancerous diseases
by: Rana E. Elnady, et al.
Published: (2023-07-01)

Kuzey Kıbrıs Türk Cumhuriyeti, Cumhuriyet Meclisi’nde Kadın Olmak
by: Tümel Sabancı, et al.
Published: (2021-09-01)

Autophagic digestion of Leishmania major by host macrophages is associated with differential expression of BNIP3, CTSE, and the miRNAs miR-101c, miR-129, and miR-210
by: Benjamin Frank, et al.
Published: (2015-07-01)

The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy
by: Yinghui Li, et al.
Published: (2021-12-01)

A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
by: Yun-Ling He, et al.
Published: (2023-12-01)

BNIP3 decreases the LPS-induced inflammation and apoptosis of chondrocytes by promoting the development of autophagy
by: Zetao Ma, et al.
Published: (2020-07-01)

Sentinel Lymph Node Metastasis in Invasive Lobular Carcinoma of the Breast
by: Hikmet Erhan Güven, et al.
Published: (2018-04-01)

BNIP3 in Lung Cancer: To Kill or Rescue?
by: Anna S. Gorbunova, et al.
Published: (2020-11-01)

Mitophagy, metabolism, and cell fate
by: Lorena Esteban-Martínez, et al.
Published: (2017-09-01)

6-Gingerol protects cardiocytes H9c2 against hypoxia-induced injury by suppressing BNIP3 expression
by: Qi Ren, et al.
Published: (2019-12-01)

Manganese (II) chloride leads to dopaminergic neurotoxicity by promoting mitophagy through BNIP3-mediated oxidative stress in SH-SY5Y cells
by: Yanning Huang, et al.
Published: (2021-06-01)

A brief overview of BNIP3L/NIX receptor‐mediated mitophagy
by: Mija Marinković, et al.
Published: (2021-12-01)

Endothelial Monocyte-Activating Polypeptide-II Induces BNIP3-Mediated Mitophagy to Enhance Temozolomide Cytotoxicity of Glioma Stem Cells via Down-Regulating MiR-24-3p
by: Jian Zhang, et al.
Published: (2018-03-01)

Resveratrol Improves Bnip3-Related Mitophagy and Attenuates High-Fat-Induced Endothelial Dysfunction
by: Chen Li, et al.
Published: (2020-08-01)

Pre-school students’ informal acquisitions regarding the concepts of point and straight line
by: Keziban Orbay, et al.
Published: (2015-07-01)

Pre-school Students’ Informal Acquisitions Regarding the Concepts of Point and Straight Line
by: Keziban ORBAY, et al.
Published: (2015-06-01)

Darstellung Der Verteilung Der Vererzungen in Der Buntmetallagerstatte Harşit-Köprübaşı
by: Hikmet AKIN, et al.
Published: (1977-06-01)

Factors Influencing Non-sentinel Node Metastasis in Patients with Macrometastatic Sentinel Lymph Node Involvement and Validation of Three Commonly Used Nomograms
by: Hikmet Erhan Güven, et al.
Published: (2017-10-01)

KENDİ KENDİNİ TEMİZLEYEN DERZ DOLGU MALZEMELERİ
by: Hikmet Ünverdi̇, et al.
Published: (2016-03-01)