New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery
We fabricated new hydrogels using polyvinyl alcohol (PVA) and succinoglycan (SG) directly isolated and obtained from <i>Sinorhizobium meliloti</i> Rm 1021 via the freeze–thaw method. Both the composition of the hydrogels and the freeze–thaw cycles were optimized to maximize the swelling...
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MDPI AG
2023-07-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/15/14/3009 |
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| author | Jae-pil Jeong Kyungho Kim Jaeyul Kim Yohan Kim Seunho Jung |
| author_facet | Jae-pil Jeong Kyungho Kim Jaeyul Kim Yohan Kim Seunho Jung |
| author_sort | Jae-pil Jeong |
| collection | DOAJ |
| description | We fabricated new hydrogels using polyvinyl alcohol (PVA) and succinoglycan (SG) directly isolated and obtained from <i>Sinorhizobium meliloti</i> Rm 1021 via the freeze–thaw method. Both the composition of the hydrogels and the freeze–thaw cycles were optimized to maximize the swelling ratio for the preparation of the PVA/SG hydrogels. During the optimization process, the morphology and conformational change in the hydrogel were analyzed by scanning electron microscopy, rheological measurements, and compressive tests. An optimized hydrogel with a maximum swelling ratio of 17.28 g/g was obtained when the composition of PVA to SG was 50:50 (PVA/SG 50/50) and the total number of freeze–thaw cycles was five. The PVA/SG 50/50 hydrogel had the largest pore with 51.24% porosity and the highest cross-over point (28.17%) between the storage modulus (G′) and the loss modulus (G″). The PVA/SG 50/50 hydrogel showed improved thermal stability owing to its interaction with thermally stable SG chains. The improvement in the thermal stability was confirmed by thermogravimetric analysis and differential scanning calorimetry. In addition, the PVA/SG 50/50 hydrogel showed differential drug release according to the corresponding pH under acidic conditions of pH 1.2 and slightly basic conditions of pH 7.4. Furthermore, the cell viability test on the HEK-293 cell line for that hydrogel demonstrated that the PVA/SG 50/50 hydrogel was non-toxic and biocompatible. Therefore, this hydrogel could be a potential scaffold capable of pH-responsive drug delivery for chronic wound dressing applications. |
| first_indexed | 2024-03-11T00:42:54Z |
| format | Article |
| id | doaj.art-54fa081e9ea54d85b2dcb5a9db44bb12 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-11T00:42:54Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-54fa081e9ea54d85b2dcb5a9db44bb122023-11-18T21:02:02ZengMDPI AGPolymers2073-43602023-07-011514300910.3390/polym15143009New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug DeliveryJae-pil Jeong0Kyungho Kim1Jaeyul Kim2Yohan Kim3Seunho Jung4Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of KoreaDepartment of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Republic of KoreaWe fabricated new hydrogels using polyvinyl alcohol (PVA) and succinoglycan (SG) directly isolated and obtained from <i>Sinorhizobium meliloti</i> Rm 1021 via the freeze–thaw method. Both the composition of the hydrogels and the freeze–thaw cycles were optimized to maximize the swelling ratio for the preparation of the PVA/SG hydrogels. During the optimization process, the morphology and conformational change in the hydrogel were analyzed by scanning electron microscopy, rheological measurements, and compressive tests. An optimized hydrogel with a maximum swelling ratio of 17.28 g/g was obtained when the composition of PVA to SG was 50:50 (PVA/SG 50/50) and the total number of freeze–thaw cycles was five. The PVA/SG 50/50 hydrogel had the largest pore with 51.24% porosity and the highest cross-over point (28.17%) between the storage modulus (G′) and the loss modulus (G″). The PVA/SG 50/50 hydrogel showed improved thermal stability owing to its interaction with thermally stable SG chains. The improvement in the thermal stability was confirmed by thermogravimetric analysis and differential scanning calorimetry. In addition, the PVA/SG 50/50 hydrogel showed differential drug release according to the corresponding pH under acidic conditions of pH 1.2 and slightly basic conditions of pH 7.4. Furthermore, the cell viability test on the HEK-293 cell line for that hydrogel demonstrated that the PVA/SG 50/50 hydrogel was non-toxic and biocompatible. Therefore, this hydrogel could be a potential scaffold capable of pH-responsive drug delivery for chronic wound dressing applications.https://www.mdpi.com/2073-4360/15/14/3009succinoglycanpolyvinyl alcoholfreeze–thawhydrogelpH-responsive drug delivery |
| spellingShingle | Jae-pil Jeong Kyungho Kim Jaeyul Kim Yohan Kim Seunho Jung New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery Polymers succinoglycan polyvinyl alcohol freeze–thaw hydrogel pH-responsive drug delivery |
| title | New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery |
| title_full | New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery |
| title_fullStr | New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery |
| title_full_unstemmed | New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery |
| title_short | New Polyvinyl Alcohol/Succinoglycan-Based Hydrogels for pH-Responsive Drug Delivery |
| title_sort | new polyvinyl alcohol succinoglycan based hydrogels for ph responsive drug delivery |
| topic | succinoglycan polyvinyl alcohol freeze–thaw hydrogel pH-responsive drug delivery |
| url | https://www.mdpi.com/2073-4360/15/14/3009 |
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